News

Hildreth to serve as interim dean, McDowell as interim associate dean of research in the College of Science

Author: Deanna Csomo McCool

Michael Hildreth, associate dean of research in the College of Science at the University of Notre Dame, will serve as interim dean of the College of Science beginning January 1, 2021. That day, Mary Ann McDowell, associate professor in the Department of Biological Sciences, will begin serving as interim associate dean of research in the college.

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Endowment honors legacy of Dean Mary E. Galvin

Author: Tammi Freehling

The College of Science at the University of Notre Dame is pleased to announce the endowment of the Science and Engineering Scholars Program. The program, started in 2018 as a pilot program to bolster student academic success in science and engineering majors, will be named in honor of the William K. Warren Foundation Dean of the College of Science, Mary E. Galvin.  

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Science and Engineering Scholars Program propels students to success

Author: Deanna Csomo McCool

“This program is, wow,” said Chelsea Popoola, a math major who plans to attend medical school. The small classes allowed her to learn the material in a tight-knit environment. “I wish I had better words to explain how much this program has done for me. Whenever we need help with anything, there are many people willing to help.”

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CEST moves to new campus location

Author: Brandi Wampler

The CEST office and laboratory space that was previously on the first floor of Fitzpatrick Hall have been relocated two floors down to the B-level of Fitzpatrick Hall.

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How T-cell targets look in three dimensions may facilitate new cancer vaccines

Author: Deanna Csomo McCool

T-cells, which hunt for traces of disease within other cells, work by identifying fragments of outsider proteins on a diseased cell’s surface and then go in for the literal kill.

With cancer, some of the mutated fragments of outsider proteins, called neoepitopes, can be recognized by T-cells and are ideal candidates for cancer vaccines. Unfortunately, those candidates are difficult to predict from genetic data alone.

A study published this month in Nature Chemical Biology by Brian Baker, the Rev. John A. Zahm Professor of Structural Biology and chair of the Department of Chemistry and Biochemistry at the University of Notre Dame, and collaborator Alexandre Harari at the Ludwig Institute for Cancer Research at the University of Lausanne (UNIL) in Lausanne, Switzerland shows that to improve those predictions and develop cancer vaccines, researchers need to think more about what neoepitopes look like in three dimensions.

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I am Here: Kelley M. H. Young

Author: Gwen O'Brien, NDWorks

Editor’s note: As classes resume on campus during this unprecedented time, faculty and staff members are, as always, HERE for Notre Dame students. Whether work is done physically on campus or remotely, the collective purpose remains to offer an unsurpassed undergraduate education that nurtures the mind, body and spirit; and to advance human understanding through scholarship, research and post-baccalaureate programs that heal, unify and enlighten. 

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Melander Lab Reports Compound that Increases Antibiotic Efficacy for MRSA

Author: Rebecca Hicks

Christian Melander, George & Winifred Clark Professor of Chemistry & Biochemistry, and Roberta Melander, Research Associate Professor, with Professor Cassandra Quave and colleagues from Emory University, have reported new research showing that an extract from the American beautyberry plant increases the efficacy of certain antibiotics in the treatment of methicillin-resistant Staphylococcus aureus (MRSA).

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Francis Castellino Receives 2020 ISTH Esteemed Career Award

Author: Mary Prorok

 

Francis J. Castellino

Francis J. Castellino, Kleiderer-Pezold Professor of Biochemistry and Director of the W.M. Keck Center for Transgene Research, has been selected as a recipient of the 2020 International Society on Thrombosis and Haemostasis (ISTH) Esteemed Career Award. This prestigious award is given to those who “have made significant contributions to the understanding, treatment and diagnosis, research and education in the thrombosis and hemostasis field.” Five recipients are selected annually.

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Dye Boosts Bioimaging Capability

Author: Sarah Chapman

 Fluorescence imaging has been a boon to research and medicine because of its ability to examine affected areas noninvasively. But the dyes used for these purposes have their disadvantages, and as resolution needs have grown stronger, the stakes for accuracy have increased exponentially.

 

Smith Schrieber

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Understand and Fight: Notre Dame researchers and the COVID-19 pandemic

Author: Deanna Csomo McCool

As Notre Dame’s laboratories went into hibernation in March, many researchers from various fields — chemistry, engineering, political science, psychology, education — looked for ways to pivot their own work toward furthering knowledge into how COVID-19, the disease caused by the SARS-CoV-2 virus, works, how it’s transmitted, and how our country and world can cope with the unexpected pandemic crisis. They decided to jump into the research at different times, but for the same reason: They knew they could help.

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