News

How T-cell targets look in three dimensions may facilitate new cancer vaccines

Author: Deanna Csomo McCool

T-cells, which hunt for traces of disease within other cells, work by identifying fragments of outsider proteins on a diseased cell’s surface and then go in for the literal kill.

With cancer, some of the mutated fragments of outsider proteins, called neoepitopes, can be recognized by T-cells and are ideal candidates for cancer vaccines. Unfortunately, those candidates are difficult to predict from genetic data alone.

A study published this month in Nature Chemical Biology by Brian Baker, the Rev. John A. Zahm Professor of Structural Biology and chair of the Department of Chemistry and Biochemistry at the University of Notre Dame, and collaborator Alexandre Harari at the Ludwig Institute for Cancer Research at the University of Lausanne (UNIL) in Lausanne, Switzerland shows that to improve those predictions and develop cancer vaccines, researchers need to think more about what neoepitopes look like in three dimensions.

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I am Here: Kelley M. H. Young

Author: Gwen O'Brien, NDWorks

Editor’s note: As classes resume on campus during this unprecedented time, faculty and staff members are, as always, HERE for Notre Dame students. Whether work is done physically on campus or remotely, the collective purpose remains to offer an unsurpassed undergraduate education that nurtures the mind, body and spirit; and to advance human understanding through scholarship, research and post-baccalaureate programs that heal, unify and enlighten. 

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Melander Lab Reports Compound that Increases Antibiotic Efficacy for MRSA

Author: Rebecca Hicks

Christian Melander, George & Winifred Clark Professor of Chemistry & Biochemistry, and Roberta Melander, Research Associate Professor, with Professor Cassandra Quave and colleagues from Emory University, have reported new research showing that an extract from the American beautyberry plant increases the efficacy of certain antibiotics in the treatment of methicillin-resistant Staphylococcus aureus (MRSA).

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Francis Castellino Receives 2020 ISTH Esteemed Career Award

Author: Mary Prorok

 

Francis J. Castellino

Francis J. Castellino, Kleiderer-Pezold Professor of Biochemistry and Director of the W.M. Keck Center for Transgene Research, has been selected as a recipient of the 2020 International Society on Thrombosis and Haemostasis (ISTH) Esteemed Career Award. This prestigious award is given to those who “have made significant contributions to the understanding, treatment and diagnosis, research and education in the thrombosis and hemostasis field.” Five recipients are selected annually.

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Dye Boosts Bioimaging Capability

Author: Sarah Chapman

 Fluorescence imaging has been a boon to research and medicine because of its ability to examine affected areas noninvasively. But the dyes used for these purposes have their disadvantages, and as resolution needs have grown stronger, the stakes for accuracy have increased exponentially.

 

Smith Schrieber

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Understand and Fight: Notre Dame researchers and the COVID-19 pandemic

Author: Deanna Csomo McCool

As Notre Dame’s laboratories went into hibernation in March, many researchers from various fields — chemistry, engineering, political science, psychology, education — looked for ways to pivot their own work toward furthering knowledge into how COVID-19, the disease caused by the SARS-CoV-2 virus, works, how it’s transmitted, and how our country and world can cope with the unexpected pandemic crisis. They decided to jump into the research at different times, but for the same reason: They knew they could help.

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Gregory Hartland Named Deputy Editor of Journal of Physical Chemistry C

Author: Rebecca Hicks

 

Hartlandnewsquare

Gregory Hartland, Professor of Chemistry & Biochemistry, has been named Deputy Editor for the Journal of Physical Chemistry C of the American Chemical Society. The journal focuses on experimental and computational physical chemistry research in energy conversion and storage, heterogeneous catalysis, and the spectroscopy and physical properties of solid-state and nanomaterials.

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NDnano announces 2020 seed grant recipients

Author: Brandi Wampler

Six faculty from the University of Notre Dame’s College of Arts and Letters, College of Engineering, and College of Science have been awarded two grants through the NDnano Seed Grant Program.

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Marya Lieberman receives 2020 Reinhold Niebuhr Award

Author: Rebecca Hicks

Marya Lieberman, professor of chemistry and biochemistry, is the 2020 winner of the Reinhold Niebuhr Award in acknowledgement of her work on Paper Analytical Devices (PADs). This award recognizes a faculty member or administrator whose life and body of academic work promotes or exemplifies the pursuit of social justice in modern life.

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