Predicting how mutations in proteins alter their ability to function is critical to understanding what drives health and disease in humans. A new study in Structure, Cell Press by scientists at the University of Notre Dame and their colleagues demonstrates how a minor mutation can have far-reaching effects on a protein, playing a role in the onset of different diseases.
Perlara, a rare diseases drug discovery company based in the San Francisco Bay area, recently announced a collaboration called PerlQuest with the University of Notre Dame’s Warren Family Research Center for Drug Discovery and Development.
The body’s immune system is a valiant weapon against disease, and harnessing its power through a technique called immunotherapy is at the forefront of current research to treat cancer and other diseases. That’s why an unexpected finding by Notre Dame researchers and their collaborators, related to the way two distinctively different peptide antigens react with one T-cell receptor, tosses a new wrench into the process of building better molecules to develop immunotherapies.
All are invited to attend the annual ND-Purdue Symposium on Soft Matter and Polymers. Hosted by the University of Notre Dame and Purdue University, the event will take place at Notre Dame’s McCourtney Hall on Saturday, October 6 from 8:15 a.m. to 5:45 p.m. EDT.
Each year, grants from the Discovery Fund are awarded to researchers who propose novel technologies and diagnostics that can improve human and environmental health.
Indiana University, Purdue University, and the University of Notre Dame invite all researchers to attend the Indiana Clinical and Translational Sciences Institute (CTSI) retreat. The event will take place at the University of Notre Dame’s McCourtney Hall on Friday, October 26, 2018 from 9:00 a.m. to 4:15 p.m.
The β-lactams are a vast family of antibiotics that include the well-known penicillins; they remain the most widely administered antibiotics around the globe. Results from the research of Jeff W. Peng, associate professor of chemistry and biochemistry, could reveal new strategies for coping with the expanding scope of β-lactam resistance now happening among Gram-negative pathogens.
Chen Dai, University of Notre Dame graduate student of chemistry and biochemistry, was recognized at the Indiana University (IU) Simon Cancer Center’s annual Cancer Research Day. Dai received first prize for his poster presentation in the basic science – graduate student category.
Structured Immunity, a Notre Dame startup and biotechnology company specializing in the optimization and validation of T cell receptor (TCR) proteins, and Medigene AG, a leading biotechnology company engaged in the development of immunotherapies for the treatment of cancer, today announced a research collaboration where Structured Immunity will provide structural immunology expertise in support of Medigene’s TCR discovery activities.
Brian Baker, Rev. John A. Zahm Professor, has received the Innovation Award from the American Cancer Society’s (ACS) local Coaches vs. Cancer program. The Innovation Award is described as being given to “an individual who demonstrates an innovative approach to treating or caring for cancer patients and their loved ones.”
Notre Dame continued the steady expansion and growth of its research, scholarship and creative endeavor programs during the most recent fiscal year, recording $141.6 million in research funding. The amount is part of a trend that has led to a 75 percent increase in external research funding awarded to the University compared to 10 years ago.
Nine faculty members from the College of Science and College of Engineering have been awarded four grants through the Center for Nano Science and Technology (NDnano) Seed Grant Program.
Beginning July 29, 2018, Notre Dame will host the 25th Biennial Conference on Chemical Education (BCCE). BCCE is a national meeting designed for college chemistry faculty, graduate students, secondary school chemistry teachers, and middle and elementary school science teachers to share ideas and best practices for chemical education.
Prashant Kamat, Rev. John A. Zahm Professor, well known for his contributions to the field of photoelectrochemistry and renewable energy research was honored with a tribute issue to him in one of the four journals of The Journal of Physical Chemistry, published by the American Chemical Society.
Trauma, or any kind of severe physical injury, continues to be today’s leading cause of death for people 46 and younger in the United States. In 2007, Dr. Scott Thomas and Dr. Mark Walsh of Memorial Hospital in South Bend were looking for a better way to treat trauma patients who arrived in the emergency room (ER) with excessive bleeding. Their search eventually led to a translational research collaboration with the W. M. Keck Center for Transgene Research at the University of Notre Dame and the development of a new method for treating trauma patients.
Notre Dame student Margo Waters has received the first Woodward Family Endowment for Excellence in NDnano Undergraduate Research.
In America, more than a million people suffer from diabetic foot ulcers.
In Latin, SalvePeds means “saving feet.”
And in SalvePeds, a new IDEA Center startup managed and marketed by a team of graduate students at the University of Notre Dame, patients may soon have a more effective option to treat diabetic foot ulcers and prevent some of the 100,000 amputations the condition necessitates every year.
University of Notre Dame licensee Hsiri Therapeutics, Inc., with its corporate headquarters located in Media, PA, has entered into a license agreement with Shionogi & Co., Ltd. regarding a collaborative licensing, research and development program to discover and develop novel therapeutics for non-tuberculous mycobacterial (NTM) diseases and tuberculosis (TB).
A study by researchers at the University of Notre Dame and the University of Missouri at Columbia shows in mice that early administration of a potent compound may increase the window of time in which some stroke patients can receive tPA, a therapeutic that dissolves blood clots.
Researchers at the University of Notre Dame have invented a new class of molecules that can be used to simplify the process used for capturing precious metals including gold, platinum, and palladium.
On Friday, May 18, 2018, more than 50 seniors were honored during The Dean’s Awards luncheon held in the Jordan Hall of Science Galleria.
Through the generosity of several donors, the Center for Stem Cells and Regenerative Medicine is able to provide summer research fellowships to six outstanding Notre Dame undergraduates this summer.
Andrew Grose, who will earn a bachelor of science degree in preprofessional studies with a major in Spanish, has been named valedictorian of the 2018 Notre Dame graduating class. Harisa Spahić, a biochemistry major with minors in anthropology and science, technology and values, is the salutatorian.
The Notre Dame Integrated Imaging Facility (NDIIF) is pleased to announce two awards for best imaging publications for calendar year 2017.
Researchers at the University of Notre Dame focused on an enzyme in gram-negative bacterium Pseudomonas aeruginosa, a pathogen that causes pneumonia and sepsis.
Researchers at Notre Dame are developing a renewable energy approach for synthesizing ammonia, an essential component of fertilizers that support the world’s food production needs. The Haber-Bosch process developed in the early 1900s for producing ammonia relies on non-renewable fossil fuels and has limited applications for only large, centralized chemical plants.