Başar Bilgiçer
Concurrent Professor
- Office
- 205C Mccourtney Hall
- Phone
- +1 574-631-1429
- bbilgicer@nd.edu
Research Areas
- Biochemistry
Research Specialties
- Medicine
- Synthesis
Prospective Graduate Students
Biography
| Year | Title |
|---|---|
| 2021-present | Professor, Dept. of Chemical & Biomolecular Engineering, University of Notre Dame |
| 2021-present | Concurrent Professor, Dept. of Chemistry & Biochemistry, University of Notre Dame |
| 2015-2021 | Associate Professor, Dept. of Chemical & Biomolecular Engineering, University of Notre Dame |
| 2015-2021 | Concurrent Associate Professor, Dept. of Chemistry & Biochemistry, University of Notre Dame |
| 2008-2015 | Assistant Professor, Dept. of Chemical & Biomolecular Engineering, University of Notre Dame |
| 2008-2015 | Concurrent Assistant Professor, Dept. of Chemistry & Biochemistry, University of Notre Dame |
| 2005-2008 | Postdoctoral Fellow, Harvard University |
| 2005 | Ph.D. in Chemistry, Tufts University |
| 1998 | B.S. in Chemistry, Bogazici University, Turkey |
Research Interests
Multivalent biomolecular interactions are very important in biological systems. A deeper understanding of the thermodynamics and kinetics of multivalent interactions in biological systems is imperative in the development of new diagnostic and therapeutic agents. My lab focuses on both understanding the basic dynamic principles of multivalent biomolecular interactions, as well as design of multivalent therapeutic and diagnostic molecules which will deliver novel solutions to complex diseases (e.g. cancer, autoimmune diseases, and allergies).
Selected Publications
- Alakhras, N. S.; Shin, J.; Smith, S. A.; Sinn, A. L.; Zhang, W. W.; Hwang, G.; Sjoerdsma, J.; Bromley, E. K.; Pollok, K. E.; Bilgicer, B. and Kaplan, M. H. "Peanut Allergen Inhibition Prevents Anaphylaxis in a Humanized Mouse Model" 2023 Science Translational Medicine, 15 (682), eadd6373. DOI: 10.1126/scitranslmed.add6373.
- Khan, S.; Mejia, F.; Shin, J.; Hwang, G.; Omstead, D. T.; Wu, J. M.; Cole, S. L.; Littlepage, L. E. and Bilgicer, B. "Disease-Driven Engineering of Peptide-Targeted DM1 Loaded Liposomal Nanoparticles for Enhanced Efficacy in Treating Multiple Myeloma by Exploring DM1 Prodrug Chemistry" 2023 Biomaterials, 292, 121913. DOI: 10.1016/j.biomaterials.2022.121913.
- Sjoerdsma, J.; Mejia, F. and Bilgicer, B. "Determination of Immunogenic Epitopes in Major House Dust Mite Allergen, Der P 2, Via Nanoallergens" 2022 Annals of Allergy Asthma & Immunology, 129 (2), pp.231-240. DOI: 10.1016/j.anai.2022.04.003.
- Fu, Y. Y.; Pajulas, A.; Wang, J.; Zhou, B. H.; Cannon, A.; Cheung, C.; Zhang, J. L.; Zhou, H. X.; Fisher, A. J.; Omstead, D. T.; Khan, S.; Han, L.; Renauld, J. C.; Paczesny, S.; Gao, H. Y.; Liu, Y. L.; Yang, L.; Tighe, R. M.; Licona-Limon, P.; Flavell, R. A.; Takatsuka, S.; Kitamura, D.; Sun, J.; Bilgicer, B.; Sears, C. R.; Yang, K. and Kaplan, M. H. "Mouse Pulmonary Interstitial Macrophages Mediate the Pro-Tumorigenic Effects of IL-9" 2022 Nature Communications, 13 (1), 3811. DOI: 10.1038/s41467-022-31596-7.
- Mejia, F.; Khan, S. and Bilgicer, B. "Liposomal Targeting Modifies Endosomal Escape: Design and Mechanistic Implications" 2022 ACS Biomaterials Science & Engineering, 8 (3), pp.1067-1073. DOI: 10.1021/acsbiomaterials.2c00100.
- Mejia, F.; Khan, S.; Omstead, D. T.; Minetos, C. and Bilgicer, B. "Identification and Optimization of Tunable Endosomal Escape Parameters for Enhanced Efficacy in Peptide-Targeted Prodrug-Loaded Nanoparticles" 2022 Nanoscale, 14 (4), pp.1226-1240. DOI: 10.1039/d1nr05357d.