- Navari Family Professor in Life Sciences, University of Notre Dame
- Professor, Wayne State University
- Associate Professor, Wayne State University
- Assistant Professor, Wayne State University
- Postdoctoral Research Associate, Rockefeller University
- Ph.D. in Chemistry, University of Chicago
- B.S. in Chemistry, University of Southern California
- B.S. in Biological Sciences, University of Southern California
- Fellow, Science Without Borders, Brazil
- Research Achievement Award, University of Notre Dame
- Astellas USA Foundation Award of the American Chemical Society
- Elected Fellow, America Association for the Advancement of Science
- Charles H. Gershenson Distinguished Faculty Fellow
The Mobashery research program integrates computation, biochemistry, molecular biology, and the organic synthesis of medically important molecules. Bringing together these different disciplines is desirable to produce both scientific and medical advances for difficult, but critically important clinical problems.
Bacterial Antibiotic Resistance, Cell Wall and Discovery of Novel Antibiotics
The studies of antibiotics and antibiotic resistance are central themes in the Mobashery laboratory. Mechanisms of resistance to β-lactam antibiotics have been studied, with a focus on methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa as two nefarious human bacterial pathogens. A multidisciplinary approach is taken towards elucidating the distinct strategies that nature has devised to counter the use of antibiotics in the clinic. Significant work has also been directed towards the bacterial cell wall. The cell wall is a structure that encases the entire organism, and it is critically important for its survival. Its complex biosynthesis and recycling are subjects of study. Discovery of novel antibacterials is another large focus of attention.
Diseases of the Extracellular Matrix
The Mobashery laboratory is interested in diseases of the extracellular matrix (ECM). The ECM is an environment that surrounds every cell in higher organisms. There are many proteins and carbohydrates within this environment, whose homeostasis is highly regulated. When these regulatory processes break down, many disparate diseases ensue. The Mobashery lab investigates how these diseases develop and progress, and designs novel therapeutics for their intervention. The diseases of matrix of interest in the Mobashery lab include diabetes, pulmonary fibrosis, traumatic-brain injury and stroke.
- Byun, B., Mahasenan, K.V., Dik, D.A., Marous, D.R., Speri, E., Kumarasiri, M., Fisher, J.F., Hermoso, J.A., Mobashery, S. "Mechanism of the Escherichia coli MltE lytic transglycosylase, the cell-wall-penetrating enzyme for Type VI secretion system assembly" 2018 Scientific Reports, 8 (1), 4110. DOI: 10.1038/s41598-018-22527-y
- Nguyen, T.T., Ding, D., Wolter, W.R., Champion, M.M., Hesek, D., Lee, M., Pérez, R.L., Schroeder, V.A., Suckow, M.A., Mobashery, S., Chang, M. "Expression of active matrix metalloproteinase-9 as a likely contributor to the clinical failure of aclerastide in treatment of diabetic foot ulcers" 2018 European Journal of Pharmacology, 834, pp. 77-83. DOI: 10.1016/j.ejphar.2018.07.014
- Mahasenan, K.V., Ding, D., Gao, M., Nguyen, T.T., Suckow, M.A., Schroeder, V.A., Wolter, W.R., Chang, M., Mobashery, S. "In Search of Selectivity in Inhibition of ADAM10" 2018 ACS Medicinal Chemistry Letters, 9 (7), pp. 708-713. DOI: 10.1021/acsmedchemlett.8b00163
- Dik, D.A., Fisher, J.F., Mobashery, S. "Cell-Wall Recycling of the Gram-Negative Bacteria and the Nexus to Antibiotic Resistance" 2018 Chemical Reviews, 118 (12), pp. 5952-5984. DOI: 10.1021/acs.chemrev.8b00277
- Tomoshige, S., Dik, D.A., Akabane-Nakata, M., Madukoma, C.S., Fisher, J.F., Shrout, J.D., Mobashery, S. "Total Syntheses of Bulgecins A, B, and C and Their Bactericidal Potentiation of the β-Lactam Antibiotics" 2018 ACS Infectious Diseases, 4 (6), pp. 860-867. DOI: 10.1021/acsinfecdis.8b00105
- Lee, M., Batuecas, M.T., Tomoshige, S., Domínguez-Gil, T., Mahasenan, K.V., Dik, D.A., Hesek, D., Millán, C., Usón, I., Lastochkin, E., Hermoso, J.A., Mobashery, S. "Exolytic and endolytic turnover of peptidoglycan by lytic transglycosylase Slt of Pseudomonas aeruginosa" 2018 Proceedings of the National Academy of Sciences of the United States of America, 115 (17), pp. 4393-4398. DOI: 10.1073/pnas.1801298115