Shahriar Mobashery

Shahriar Mobashery

Bioorganic Chemistry and Biochemistry


Navari Family Professor in Life Sciences, University of Notre Dame
Professor, Wayne State University
Associate Professor, Wayne State University
Assistant Professor, Wayne State University
Postdoctoral Research Associate, Rockefeller University
Ph.D. in Chemistry, University of Chicago
B.S. in Chemistry, University of Southern California
B.S. in Biological Sciences, University of Southern California

Selected Awards

Fellow, Science Without Borders, Brazil
Research Achievement Award, University of Notre Dame
Astellas USA Foundation Award of the American Chemical Society
Elected Fellow, America Association for the Advancement of Science
Charles H. Gershenson Distinguished Faculty Fellow

Prof. Mobashery's Current CV

Research Interests

The Mobashery research program integrates computation, biochemistry, molecular biology, and the organic synthesis of medically important molecules. Bringing together these different disciplines is desirable to produce both scientific and medical advances for difficult, but critically important clinical problems.

Bacterial Antibiotic Resistance, Cell Wall and Discovery of Novel Antibiotics

The studies of antibiotics and antibiotic resistance are central themes in the Mobashery laboratory. Mechanisms of resistance to β-lactam antibiotics have been studied, with a focus on methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa as two nefarious human bacterial pathogens. A multidisciplinary approach is taken towards elucidating the distinct strategies that nature has devised to counter the use of antibiotics in the clinic. Significant work has also been directed towards the bacterial cell wall. The cell wall is a structure that encases the entire organism, and it is critically important for its survival. Its complex biosynthesis and recycling are subjects of study. Discovery of novel antibacterials is another large focus of attention.

Diseases of the Extracellular Matrix

The Mobashery laboratory is interested in diseases of the extracellular matrix (ECM). The ECM is an environment that surrounds every cell in higher organisms. There are many proteins and carbohydrates within this environment, whose homeostasis is highly regulated. When these regulatory processes break down, many disparate diseases ensue. The Mobashery lab investigates how these diseases develop and progress, and designs novel therapeutics for their intervention. The diseases of matrix of interest in the Mobashery lab include diabetes, pulmonary fibrosis, traumatic-brain injury and stroke.

Recent Papers

  • Byun, B., Mahasenan, K.V., Dik, D.A., Marous, D.R., Speri, E., Kumarasiri, M., Fisher, J.F., Hermoso, J.A., Mobashery, S. "Mechanism of the Escherichia coli MltE lytic transglycosylase, the cell-wall-penetrating enzyme for Type VI secretion system assembly" 2018 Scientific Reports, 8 (1), 4110. DOI: 10.1038/s41598-018-22527-y
  • Nguyen, T.T., Ding, D., Wolter, W.R., Champion, M.M., Hesek, D., Lee, M., Pérez, R.L., Schroeder, V.A., Suckow, M.A., Mobashery, S., Chang, M. "Expression of active matrix metalloproteinase-9 as a likely contributor to the clinical failure of aclerastide in treatment of diabetic foot ulcers" 2018 European Journal of Pharmacology, 834, pp. 77-83. DOI: 10.1016/j.ejphar.2018.07.014
  • Mahasenan, K.V., Ding, D., Gao, M., Nguyen, T.T., Suckow, M.A., Schroeder, V.A., Wolter, W.R., Chang, M., Mobashery, S. "In Search of Selectivity in Inhibition of ADAM10" 2018 ACS Medicinal Chemistry Letters, 9 (7), pp. 708-713. DOI: 10.1021/acsmedchemlett.8b00163
  • Dik, D.A., Fisher, J.F., Mobashery, S. "Cell-Wall Recycling of the Gram-Negative Bacteria and the Nexus to Antibiotic Resistance" 2018 Chemical Reviews, 118 (12), pp. 5952-5984. DOI: 10.1021/acs.chemrev.8b00277
  • Tomoshige, S., Dik, D.A., Akabane-Nakata, M., Madukoma, C.S., Fisher, J.F., Shrout, J.D., Mobashery, S. "Total Syntheses of Bulgecins A, B, and C and Their Bactericidal Potentiation of the β-Lactam Antibiotics" 2018 ACS Infectious Diseases, 4 (6), pp. 860-867. DOI: 10.1021/acsinfecdis.8b00105
  • Lee, M., Batuecas, M.T., Tomoshige, S., Domínguez-Gil, T., Mahasenan, K.V., Dik, D.A., Hesek, D., Millán, C., Usón, I., Lastochkin, E., Hermoso, J.A., Mobashery, S. "Exolytic and endolytic turnover of peptidoglycan by lytic transglycosylase Slt of Pseudomonas aeruginosa" 2018 Proceedings of the National Academy of Sciences of the United States of America, 115 (17), pp. 4393-4398. DOI: 10.1073/pnas.1801298115

Contact Information

  • Navari Family Professor in Life Sciences
  • Office: 354B McCourtney Hall
  • Phone: 574-631-2933
  • Send an email

Primary Research Areas

Research Specialties