Rui Liu

Assistant Research Professor

Assistant Research Professor
379 Stepan Chemistry
Notre Dame, IN 46556

Research Areas

  • Biochemistry

Research Specialties

  • Medicine
  • Synthesis

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Year Title
2022-present Assistant Research Professor, University of Notre Dame
2017-2022 Research Scientist, University of Notre Dame
2013-2017 Postdoctoral Fellow, University of Notre Dame
2011-2012 Assistant Investigator, Chinese Academy of Sciences
2011 Ph.D. in Medicinal Chemistry, Peking Union Medical College
2007 M.S. in Medicinal Chemistry, Soochow University
2004 B.S. in Pharmacy, Hebei University

Selected Awards

2009   Outstanding Graduate of Peking Union Medical College

2008   Outstanding Master's Thesis, Soochow University

Research Interests

My research focuses on developing new synthetic methodology and incorporating it into the discovery of drugs that can treat various diseases caused by viruses, parasites, or bacteria. My most recent work focuses on a new agent discovered that is effective against Mycobacterium tuberculosis (Mtb) and nontuberculous mycobacteria (NTM). Exploiting the iron sequestration processes of microorganisms, my research also includes development of novel siderophore drug conjugates (sideromycins) with activity against Gram-positive and Gram-negative bacteria, especially multi-drug resistant strains listed by the WHO as being of most concern.

Selected Publications

  • Liu, R.; Marshall, K.; Ma, R.; Pham, K.; Shetye, G.; Liu, Z. H.; Cho, S. Y.; Jeong, H.; Franzblau, S. G.; Moraski, G. C. and Miller, M. J. "Syntheses and Studies of Deuterated Imdiazo[1,2-a]Pyridine-3-Carboxamides with Potent Anti-Tuberculosis Activity and Improved Metabolic Properties" 2022 Bioorganic Chemistry, 128, 106074. DOI: 10.1016/j.bioorg.2022.106074.
  • Liu, R.; Miller, P. A. and Miller, M. J. "Conjugation of Aztreonam, a Synthetic Monocyclic Beta-Lactam Antibiotic, to a Siderophore Mimetic significantly Expands Activity Against Gram-Negative Bacteria" 2021 ACS Infectious Diseases, 7 (11), pp.2979-2986. DOI: 10.1021/acsinfecdis.1c00458.
  • Miller, M. J. and Liu, R. "Design and Syntheses of New Antibiotics Inspired by Nature's Quest for Iron in an Oxidative Climate" 2021 Accounts of Chemical Research, 54 (7), pp.1646-1661. DOI: 10.1021/acs.accounts.1c00004.
  • Liu, R.; Markley, L.; Miller, P. A.; Franzblau, S.; Shetye, G.; Ma, R.; Savkova, K.; Mikusova, K.; Lee, B. S.; Pethe, K.; Moraski, G. C. and Miller, M. J. "Hydride-Induced Meisenheimer Complex Formation Reflects Activity of Nitro Aromatic Anti-Tuberculosis Compounds" 2021 RSC Medicinal Chemistry, 12 (1), pp.62-72. DOI: 10.1039/d0md00390e.
  • Eckhardt, T.; Goddard, R.; Lehmann, C.; Richter, A.; Sahile, H. A.; Liu, R.; Tiwari, R.; Oliver, A. G.; Miller, M. J.; Seidel, R. W. and Imming, P. "Crystallographic Evidence for Unintended Benzisothiazolinone 1-Oxide Formation from Benzothiazinones through Oxidation" 2020 Acta Crystallographica Section C-Structural Chemistry, 76 pp.907-+. DOI: 10.1107/S2053229620010931.
  • Liu, R.; Krchnak, V.; Brown, S. N. and Miller, M. J. "Deuteration of BTZ043 Extends the Lifetime of Meisenheimer Intermediates to the Antituberculosis Nitroso Oxidation State" 2019 ACS Medicinal Chemistry Letters, 10 (10), pp.1462-1466. DOI: 10.1021/acsmedchemlett.9b00308.