Roberta Melander

Roberta Melander

Biography

2018-present
Research Associate Professor, University of Notre Dame
2011-present
Editor, Chemical Biology and Drug Design
2011-2018
Research Assistant Professor, North Carolina State University
2009-2011
Postdoctoral Research Associate, North Carolina State University
2008-2009
Postdoctoral Research Associate, University College London
2008
Ph.D. in Biological Chemistry, University of Manchester
2004
M.Chem. in Medicinal Chemistry, University of Manchester Institute of Science and Technology

Research Interests

My research centers on using small molecules to study and control bacterial behaviors. I am interested in developing molecules that mediate: antibiotic resistance and tolerance, evolution of resistance to antimicrobial agents, and virulence, as potential novel therapeutic options for treating bacterial infections. I am also working to identify molecules that influence secondary metabolite production to identify novel antimicrobials.

Recent Papers

  • Huggins, W.M., Barker, W.T., Baker, J.T., Hahn, N.A., Melander, R.J., Melander, C. "Meridianin D Analogues Display Antibiofilm Activity against MRSA and Increase Colistin Efficacy in Gram-Negative Bacteria" 2018 ACS Medicinal Chemistry Letters, 9 (7), pp. 702-707. DOI: 10.1021/acsmedchemlett.8b00161
  • Minrovic, B.M., Jung, D., Melander, R.J., Melander, C. "A New Class of Adjuvants Enables Lower Dosing of Colistin Against Acinetobacter baumannii" 2018 ACS Infectious Diseases, Article in Press. DOI: 10.1021/acsinfecdis.8b00103
  • Milton, M.E., Minrovic, B.M., Harris, D.L., Kang, B., Jung, D., Lewis, C.P., Thompson, R.J., Melander, R.J., Zeng, D., Melander, C., Cavanagh, J. "Re-sensitizing multidrug resistant bacteria to antibiotics by targeting bacterial response regulators: Characterization and comparison of interactions between 2-aminoimidazoles and the response regulators BfmR from acinetobacter baumannii and QseB from Francisella spp." 2018 Frontiers in Molecular Biosciences, 5 (FEB), 15. DOI: 10.3389/fmolb.2018.00015​​​​​​​
  • Melander, R.J., Melander, C. "Antibiotic adjuvants" 2018 Topics in Medicinal Chemistry, 25, pp. 89-118. DOI: 10.1007/7355_2017_10​​​​​​​
  • Melander, R.J., Zurawski, D.V., Melander, C. "Narrow-spectrum antibacterial agents" 2018 MedChemComm, 9 (1), pp. 12-21. DOI: 10.1039/c7md00528h
  • Huggins, W.M., Vu Nguyen, T., Hahn, N.A., Baker, J.T., Kuo, L.G., Kaur, D., Melander, R.J., Gunn, J.S., Melander, C. "2-Aminobenzimidazoles as antibiofilm agents against Salmonella enterica serovar Typhimurium" 2018 MedChemComm, 9 (9), pp. 1547-1552. DOI: 10.1039/C8MD00298C

Contact Information

  • Research Associate Professor
  • Office: 252 McCourtney Hall
  • Send an email

Primary Research Areas

Research Specialties