Roberta Melander

Roberta Melander

Biography

2018-present
Research Associate Professor, University of Notre Dame
2011-present
Editor, Chemical Biology and Drug Design
2011-2018
Research Assistant Professor, North Carolina State University
2009-2011
Postdoctoral Research Associate, North Carolina State University
2008-2009
Postdoctoral Research Associate, University College London
2008
Ph.D. in Biological Chemistry, University of Manchester
2004
M.Chem. in Medicinal Chemistry, University of Manchester Institute of Science and Technology

Research Interests

My research centers on using small molecules to study and control bacterial behaviors. I am interested in developing molecules that mediate: antibiotic resistance and tolerance, evolution of resistance to antimicrobial agents, and virulence, as potential novel therapeutic options for treating bacterial infections. I am also working to identify molecules that influence secondary metabolite production to identify novel antimicrobials.

Recent Papers

  • Huggins, W. M.; Barker, W. T.; Baker, J. T.; Hahn, N. A.; Melander, R. J.; Melander, C. "Meridianin D Analogues Display Antiobiofilm Activity Against MRSA and Increase Colistin Efficacy in Gram-Negative Bacteria." ACS Med. Chem. Lett. 2018, 25(9), 702-707.
  • Minrovic, B. M.; Jung, D.; Melander, R. J.; Melander, C. "New Class of Adjuvants Enables Lower Dosing of Colistin Against Acinetobacter baumannii." ACS Infect. Dis. 2018, in press.
  • Melander, R. J.; Zurawski, D. V.; Melander, C. "Narrow-Spectrum Antibacterial Agents." MedChemComm 2018, 9, 12-21.
  • Milton, M. E.; Minrovic, B. M.; Harris, D. L.; Kang, B.; Jung, D.; Lewis, C. P.; Thompson, R. J.; Melander, R. J.; Zeng, D.; Melander, C.; Cavanagh, J. "Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions Between 2-Aminoimidazoles and the Response Regulators BfmR from Acinetobacter baumannii and QseB from Francisella spp." Front. Mol. Biosci. 2018, 13(5), 15.
  • Barker, W. T.; Martin, S. E.; Chandler, C. E.; Nguyen, T. V.; Harris, T. L.; Goodell, C.; Melander, R. J.; Doi, Y.; Ernst, R. K.; Melander, C. "Small Molecule Adjuvants that Suppress Both Chromosomal and mcr-1 Encoded Colistin-Resistance and Amplify Colistin Efficacy in Polymyxin-Susceptible Bacteria." Bioorg. Med. Chem. 2017, 25(20), 5749-5753.
  • Milton, M. E.; Allen, C. L.; Feldmann, E. A.; Bobay, B. G.; Stephens, M. D.; Melander, R. J.; Theisen, K. E.; Zeng, D.; Thompson, R. J.; Melander, C.; Cavanagh, J. "Structure of the Francisella Response Regulator QseB Receiver Domain, and Characterization of QseB Inhibition by Antibiofilm 2-Aminoimidazole-Based Compounds." Mol. Microbio. 2017, 106(2), 223-235.

Contact Information

  • Research Associate Professor
  • Office: 252 McCourtney Hall
  • Send an email

Primary Research Areas

Research Specialties