Roberta Melander

Roberta Melander

Biography

2018-present
Research Associate Professor, University of Notre Dame
2011-present
Editor, Chemical Biology and Drug Design
2011-2018
Research Assistant Professor, North Carolina State University
2009-2011
Postdoctoral Research Associate, North Carolina State University
2008-2009
Postdoctoral Research Associate, University College London
2008
Ph.D. in Biological Chemistry, University of Manchester
2004
M.Chem. in Medicinal Chemistry, University of Manchester Institute of Science and Technology

Research Interests

My research centers on using small molecules to study and control bacterial behaviors. I am interested in developing molecules that mediate: antibiotic resistance and tolerance, evolution of resistance to antimicrobial agents, and virulence, as potential novel therapeutic options for treating bacterial infections. I am also working to identify molecules that influence secondary metabolite production to identify novel antimicrobials.

Recent Papers

  • Hubble, V. B., Hubbard, B. A., Minrovic, B. M., Melander, R. J., Melander, C. "Using Small-Molecule Adjuvants to Repurpose Azithromycin for Use against Pseudomonas aeruginosa" 2019 ACS Infectious Diseases, 5 (1), pp. 141-151. DOI:10.1021/acsinfecdis.8b00288.
  • Jeon, A. B., Ackart, D. F., Li, W., Jackson, M., Melander, R. J., Melander, C., Abramovitch, R. B., Chicco, A. J., Basaraba, R. J., Obreg√≥n-Henao, A. "2-aminoimidazoles collapse mycobacterial proton motive force and block the electron transport chain" 2019 Scientific Reports, 9 (1), 1513. DOI:10.1038/s41598-018-38064-7.
  • Martin, S. E., Melander, R. J., Brackett, C. M., Scott, A. J., Chandler, C. E., Nguyen, C. M., Minrovic, B. M., Harrill, S. E., Ernst, R. K., Manoil, C., Melander, C. "Small Molecule Potentiation of Gram-Positive Selective Antibiotics against Acinetobacter baumannii" 2019 ACS Infectious Diseases, 5 (7), pp. 1223-1230. DOI:10.1021/acsinfecdis.9b00067.
  • Minrovic, B. M., Hubble, V. B., Barker, W. T., Jania, L. A., Melander, R. J., Koller, B. H., Melander, C. "Second-Generation Tryptamine Derivatives Potently Sensitize Colistin Resistant Bacteria to Colistin" 2019 ACS Medicinal Chemistry Letters, 10 (5), pp. 828-833. DOI:10.1021/acsmedchemlett.9b00135.
  • Nguyen, T. V., Minrovic, B. M., Melander, R. J., Melander, C. "Identification of Anti-Mycobacterial Biofilm Agents Based on the 2-Aminoimidazole Scaffold" 2019 ChemMedChem, 14 (9), pp. 927-937. DOI:10.1002/cmdc.201900033.
  • Nguyen, T. V., Peszko, M. T., Melander, R. J., Melander, C. "Using 2-aminobenzimidazole derivatives to inhibit Mycobacterium smegmatis biofilm formation" 2019 MedChemComm, 10 (3), pp. 456-459. DOI:10.1039/c9md00025a.

Contact Information

Primary Research Areas

Research Specialties