Roberta Melander

Roberta Melander

Biography

2018-present
Research Associate Professor, University of Notre Dame
2011-present
Editor, Chemical Biology and Drug Design
2011-2018
Research Assistant Professor, North Carolina State University
2009-2011
Postdoctoral Research Associate, North Carolina State University
2008-2009
Postdoctoral Research Associate, University College London
2008
Ph.D. in Biological Chemistry, University of Manchester
2004
M.Chem. in Medicinal Chemistry, University of Manchester Institute of Science and Technology

Research Interests

My research centers on using small molecules to study and control bacterial behaviors. I am interested in developing molecules that mediate: antibiotic resistance and tolerance, evolution of resistance to antimicrobial agents, and virulence, as potential novel therapeutic options for treating bacterial infections. I am also working to identify molecules that influence secondary metabolite production to identify novel antimicrobials.

Recent Publications

  • Weig, A. W., Barlock, S. L., O'Connor, P. M., Marciano, O. M., Smith, R., Ernst, R. K., Melander, R. J., Melander, C. "A scaffold hopping strategy to generate new aryl-2-amino pyrimidine MRSA biofilm inhibitors" 2021 RSC Medicinal Chemistry, 12 (2), pp. 293-296. DOI:10.1039/d0md00238k.
  • Barker, W. T., Jania, L. A., Melander, R. J., Koller, B. H., Melander, C. "Eukaryotic phosphatase inhibitors enhance colistin efficacy in gram-negative bacteria" 2020 Chemical Biology and Drug Design, 96 (5), pp. 1180-1186. DOI:10.1111/cbdd.13735.
  • Hubble, V. B., Bartholomew, K. R., Weig, A. W., Brackett, S. M., Barlock, S. L., Mattingly, A. E., Nemeth, A. M., Melander, R. J., Melander, C. "Augmenting the Activity of Macrolide Adjuvants against Acinetobacter baumannii" 2020 ACS Medicinal Chemistry Letters, 11 (9), pp. 1723-1731. DOI:10.1021/acsmedchemlett.0c00276.
  • Mattingly, A. E., Cox, K. E., Smith, R., Melander, R. J., Ernst, R. K., Melander, C. "Screening an Established Natural Product Library Identifies Secondary Metabolites That Potentiate Conventional Antibiotics" 2020 ACS Infectious Diseases, 6 (10), pp. 2629-2640. DOI:10.1021/acsinfecdis.0c00259.
  • Melander, R. J., Basak, A. K., Melander, C. "Natural products as inspiration for the development of bacterial antibiofilm agents" 2020 Natural Product Reports, 37 (11), pp. 1454-1477. DOI:10.1039/d0np00022a.
  • Rasapalli, S., Murphy, Z. F., Sammeta, V. R., Golen, J. A., Weig, A. W., Melander, R. J., Melander, C., Macha, P., Vasudev, M. C. "Synthesis and biofilm inhibition studies of 2-(2-amino-6-arylpyrimidin-4-yl)quinazolin-4(3H)-ones" 2020 Bioorganic and Medicinal Chemistry Letters, 30 (23), DOI:10.1016/j.bmcl.2020.127550.

Contact Information

Primary Research Areas

Research Specialties