
Roberta Melander
Biography
- 2018-present
- Research Associate Professor, University of Notre Dame
- 2011-present
- Editor, Chemical Biology and Drug Design
- 2011-2018
- Research Assistant Professor, North Carolina State University
- 2009-2011
- Postdoctoral Research Associate, North Carolina State University
- 2008-2009
- Postdoctoral Research Associate, University College London
- 2008
- Ph.D. in Biological Chemistry, University of Manchester
- 2004
- M.Chem. in Medicinal Chemistry, University of Manchester Institute of Science and Technology
Research Interests
My research centers on using small molecules to study and control bacterial behaviors. I am interested in developing molecules that mediate: antibiotic resistance and tolerance, evolution of resistance to antimicrobial agents, and virulence, as potential novel therapeutic options for treating bacterial infections. I am also working to identify molecules that influence secondary metabolite production to identify novel antimicrobials.
Recent Publications
- Siwawannapong, K.; Nemeth, A. M.; Melander, R. J.; Rong, J.; Davis, J. R.; Taniguchi, M.; Carpenter, M. E.; Lindsey, J. S. and Melander, C. C. "Simple Dipyrrin Analogues of Prodigiosin for use as Colistin Adjuvants" 2022 ChemMedChem, in press. DOI: 10.1002/cmdc.202200286.
- Woolard, K. J.; Sandala, J. L.; Melander, R. J.; Gunn, J. S. and Melander, C. "Development of Small Molecules that Work Cooperatively with Ciprofloxacin to Clear Salmonella Biofilms in a Chronic Gallbladder Carriage Model" 2022 European Journal of Medicinal Chemistry, 232, 114203. DOI: 10.1016/j.ejmech.2022.114203.
- Zeiler, M. J.; Connors, G. M.; Durling, G. M.; Oliver, A. G.; Marquez, L.; Melander, R. J.; Quave, C. L. and Melander, C. "Synthesis, Stereochemical Confirmation, and Derivatization of 12(S),16 Epsilon-Dihydroxycleroda-3,13-Dien-15,16-Olide, a Clerodane Diterpene that Sensitizes Methicillin-Resistant Staphylococcus Aureus to Beta-Lactam Antibiotics" 2022 Angewandte Chemie-International Edition, e202117458. DOI: 10.1002/anie.202117458.
- Melander, R. J.; Mattingly, A. E. and Melander, C. "Phenotypic Screening of Compound Libraries as a Platform for the Identification of Antibiotic Adjuvants: Identification of Colistin Adjuvants from a Natural Product Library" 2022 Methods in Enzymology, 665, pp.153-176. DOI: 10.1016/bs.mie.2021.11.005.
- Li, H.; Mattingly, A. E.; Jania, L. A.; Smith, R.; Melander, R. J.; Ernst, R. K.; Koller, B. H. and Melander, C. "Benzimidazole Isosteres of Salicylanilides are Highly Active Colistin Adjuvants" 2021 ACS Infectious Diseases, 7 (12), pp.3303-3313. DOI: 10.1021/acsinfecdis.1c00463.
- Weig, A. W.; Barlock, S. L.; O'Connor, P. M.; Marciano, O. M.; Smith, R.; Ernst, R. K.; Melander, R. J. and Melander, C. "A Scaffold Hopping Strategy to Generate New Aryl-2-Amino Pyrimidine MRSA Biofilm Inhibitors" 2021 RSC Medicinal Chemistry, 12 (2), pp.293-296. DOI: 10.1039/d0md00238k.
Contact Information
- Research Associate Professor
- Office: 252 McCourtney Hall
- Send an email
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