Roberta Melander

Roberta Melander


Research Associate Professor, University of Notre Dame
Editor, Chemical Biology and Drug Design
Research Assistant Professor, North Carolina State University
Postdoctoral Research Associate, North Carolina State University
Postdoctoral Research Associate, University College London
Ph.D. in Biological Chemistry, University of Manchester
M.Chem. in Medicinal Chemistry, University of Manchester Institute of Science and Technology

Research Interests

My research centers on using small molecules to study and control bacterial behaviors. I am interested in developing molecules that mediate: antibiotic resistance and tolerance, evolution of resistance to antimicrobial agents, and virulence, as potential novel therapeutic options for treating bacterial infections. I am also working to identify molecules that influence secondary metabolite production to identify novel antimicrobials.

Recent Papers

  • Hubble, V. B., Hubbard, B. A., Minrovic, B. M., Melander, R. J., Melander, C. "Using Small-Molecule Adjuvants to Repurpose Azithromycin for Use against Pseudomonas aeruginosa" 2019 ACS Infectious Diseases, 5 (1), pp. 141-151. DOI:10.1021/acsinfecdis.8b00288.
  • Jeon, A. B., Ackart, D. F., Li, W., Jackson, M., Melander, R. J., Melander, C., Abramovitch, R. B., Chicco, A. J., Basaraba, R. J., Obreg√≥n-Henao, A. "2-aminoimidazoles collapse mycobacterial proton motive force and block the electron transport chain" 2019 Scientific Reports, 9 (1), 1513. DOI:10.1038/s41598-018-38064-7.
  • Martin, S. E., Melander, R. J., Brackett, C. M., Scott, A. J., Chandler, C. E., Nguyen, C. M., Minrovic, B. M., Harrill, S. E., Ernst, R. K., Manoil, C., Melander, C. "Small Molecule Potentiation of Gram-Positive Selective Antibiotics against Acinetobacter baumannii" 2019 ACS Infectious Diseases, 5 (7), pp. 1223-1230. DOI:10.1021/acsinfecdis.9b00067.
  • Minrovic, B. M., Hubble, V. B., Barker, W. T., Jania, L. A., Melander, R. J., Koller, B. H., Melander, C. "Second-Generation Tryptamine Derivatives Potently Sensitize Colistin Resistant Bacteria to Colistin" 2019 ACS Medicinal Chemistry Letters, 10 (5), pp. 828-833. DOI:10.1021/acsmedchemlett.9b00135.
  • Nguyen, T. V., Minrovic, B. M., Melander, R. J., Melander, C. "Identification of Anti-Mycobacterial Biofilm Agents Based on the 2-Aminoimidazole Scaffold" 2019 ChemMedChem, 14 (9), pp. 927-937. DOI:10.1002/cmdc.201900033.
  • Nguyen, T. V., Peszko, M. T., Melander, R. J., Melander, C. "Using 2-aminobenzimidazole derivatives to inhibit Mycobacterium smegmatis biofilm formation" 2019 MedChemComm, 10 (3), pp. 456-459. DOI:10.1039/c9md00025a.

Contact Information

Primary Research Areas

Research Specialties