Rich Taylor

Rich Taylor

Synthetic Organic Chemistry Conformation-Activity Relationships of Polyketide Natural Products

Biography

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2017-present
Interim Director of Notre Dame California
2014-2017
Interim Director of the Warren Family Research Center for Drug Discovery and Development, University of Notre Dame
2013-2016
Associate Vice President for Research, University of Notre Dame
2008-2013
Associate Dean, College of Science, University of Notre Dame
2004-present
Professor, University of Notre Dame
2001-2004
Associate Professor, University of Notre Dame
1995-2001
Assistant Professor, University of Notre Dame
1992-1995
Merck Postdoctoral Associate, Stanford University
1992
Ph.D. in Chemistry, Rensselaer Polytechnic Institute
1987
B.S. in Chemistry, State University of New York, Oswego

Selected Awards

2017
University of Notre Dame Faculty Award
2016
Chair of the Gordon Research Conference on Natural Products and Bioactive Compounds
2010
5th Annual Negishi-Brown Lectures, Plenary Speaker
2009
Elected Fellow, American Association for the Advancement of Science
2007
Rev. Edmund P. Joyce Award for Excellence in Undergraduate Teaching
2007
Silveira Distinguished Lecturer, SUNY, Oswego
2002
Kaneb Teaching Award
1998
NSF CAREER Award

Research Interests

Chemical and Biological Synthetic Technologies for Accessing Biologically Active Natural Products

Our group is focused on the development of chemical and biological synthetic technologies for the production of natural products and natural product analogues and the study of their therapeutic potential for cancer and rare disease indications. In our lab, chemical synthesis tools such as methodology development and total synthesis are complemented by biological synthesis techniques such as bacterial fermentation, genetic and chemical manipulation, and heterologous expression. The power of synthesis enables access to the complex structures that are the foundation for a medicinal chemistry program.

  • Chemical Methodology Development and Total Synthesis
  • Bacterial Fermentation and Chemical and Genetic Manipulation of Microorganisms
  • Small Molecule Conformational Analysis and Analogue Synthesis
  • Biological Assay Development and Screening

Current projects include the development of chemical and biological methods for oxidative processing of putative biosynthetic intermediates towards the anti-cancer natural product, zampanolide and the anti-fungal, cyclopropane-containing polyketide, ambruticin. For several years, our lab has been studying the polyketide natural products, GEX1A and pladienolide, for their potential in rare diseases such as Niemann-Pick Type C and certain rare cancers.

The Identification of New Leads for Rare and Ultra-rare Diseases

Our lab also contributes to several collaborative rare disease programs within the Warren Center for Drug Discovery seeking therapeutic leads for rare indications such as NGly1 deficiency, Cori disease, and Behcet's disease.

 

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Recent Papers

  • Kearney, Sara E.; Zahoránszky-Kőhalmi, Gergely; Brimacombe, Kyle R.; Henderson, Mark J.; Lynch, Caitlin; Zhao, Tongan; et al. (2018): Canvass: A Crowd-Sourced, Natural Product Screening Library for Exploring Biological Space. ChemRxiv Preprint.
  • Dodge, G.; Ronnow, D.; Taylor, R.; Smith, J. L. "Molecular Basis for Olefin Rearrangement in the Gephyronic Acid Polyketide Synthase" ACS Chem. Biol. 201813, 2699–2707.
  • Granatosky, E.; DiPrimio, N.; Pickering, J.; Stevens, D. C.; Perlstein, E.; Taylor, R. E. “GEX1A, a Polyketide from Streptomyces chromofuscus, Corrects the Cellular Defects Associated with Niemann-Pick Type C1 in Human Fibroblasts” J. Nat. Prod. 2018, 81, 2018-2025.
  • Muthukumar, Y.; Münkemer, J.; Mathieu, D.; Richter, C.; Schwalbe, H.; Steinmetz, H.; Kessler, W.; Reichelt, J.; Beutling, U.; Frank, R.; Büssow, K.; van den Heuvel, J.; Brönstrup, M.; Taylor, R. E.; Laschat, S.; Sasse, F. “Investigations on the mode of action of gephyronic acid, an inhibitor of eukaryotic protein translation from myxobacteria” PLOS ONE 2018, 13, e0201605.
  • Larsen, E. M.; Chang, C.-F.; Sakata-Kato, T.; Arico, J. W.; Lombardo, V.; Wirth, D. F.; Taylor, R. E. Conformation-Guided Analogue Design Identifies Potential Antimalarial Compounds through Inhibition of Mitochondrial Respiration Org. Biomol. Chem. 2018, 16, 5403.
  • Woods, L. M.; Arico, J. W.; Frein, J. D.; Sackett, D. L.; Taylor, R. E. "Synthesis and Biological Evaluation of 7-Deoxy-Epothilone Analogues." Int. J. Mol. Sci. 2017, 18, 648.
  • Wagner, D. T.; Stevens, D. C.; Mehaffey, M. R.; Manion, H. R.; Taylor, R. E.; Brodbelt, J. S.; Keatinge-Clay, A. T. "alpha-Methylation follows condensation in the gephyronic acid modular polyketide synthase." Chem. Commun. 2016, 52, 8822.
  • Chang, C.; Stefan, E.; Taylor, R. E. "Total Synthesis and Structural Reassignment of Lyngbyaloside C Highlighted by Intermolecular Ketene Esterification." Chem.-Eur. J. 2015, 21, 10681-10686.
  • Stefan, E.; Taylor, R. E. "1,5-Hydride transfer protocol for the synthesis of beta-branched polyketide structural units." Tetrahedron Lett. 2015, 56, 3416.
  • Naini, A.; Muthukumar, Y.; Raja, A.; Franke, R.; Harrier, I.; Smith,Amos B.,,III; Lee, D.; Taylor, R. E.; Sasse, F.; Kalesse, M. "The Synthesis and Biological Evaluation of Desepoxyisotedanolide and a Comparison with Desepoxytedanolide." Angew. Chem.-Int. Edit2015, 54, 6935-6939.
  • Larsen, E. M.; Wilson, M. R.; Taylor, R. E. Conformation-activity relationships of polyketide natural products. Nat. Prod. Rep. 2015, 32, 1183-1206.

 

Contact Information

  • Professor; Interim Director, Notre Dame California
  • Office: 305A McCourtney Hall
  • Phone: 574-631-5674
  • Send an email

Primary Research Areas

Research Specialties