Merlin Bruening

Merlin Bruening

Thin Films for Selective Protein Separations

Biography

2016-present
Concurrent Professor, Department of Chemistry & Biochemistry, University of Notre Dame
2016-present
Professor, Department of Chemical & Biomolecular Engineering, University of Notre Dame
2007-2016
Professor, Michigan State University
2002-2007
Associate Professor, Michigan State University
1997-2002
Assistant Professor, Michigan State University
1995-1997
NIH Postdoctoral Fellow, Texas A&M University
1995
Ph.D. in Chemistry, The Weizmann Institute of Science
1990
M.S. in Chemistry, Brigham Young University
1989
B.S. in Chemical Engineering, Brigham Young University

Selected Awards

2016
Benedetti-Pichler Award of the American Microchemical Society
2015
MSU Innovation of the Year
2014
MSU College of Natural Science Distinguished Faculty Award
2000
Society for Electroanalytical Chemistry Young Investigator Award

Research Interests

The Bruening Group develops new thin films for specific protein capture in porous membranes, ion separations in electrodialysis, and controlled protein digestion prior to analysis with mass spectrometry. Potential applications include protein purification, antibody characterization and sequencing, and salt purification or recycling.

Recent Papers

  • Ahmad, M., Tang, C., Yang, L., Yaroshchuk, A., Bruening, M. L. "Layer-by-layer modification of aliphatic polyamide anion-exchange membranes to increase Cl-/SO42- selectivity" 2019 Journal of Membrane Science, 578 pp. 209-219. DOI:10.1016/j.memsci.2019.02.018.
  • Feroz, H., Meisenhelter, J., Jokhadze, G., Bruening, M., Kumar, M. "Rapid screening and scale-up of ultracentrifugation-free, membrane-based procedures for purification of His-tagged membrane proteins" 2019 Biotechnology Progress, DOI:10.1002/btpr.2859.
  • Yaroshchuk, A., Bruening, M. L., Zholkovskiy, E. "Modelling nanofiltration of electrolyte solutions" 2019 Advances in Colloid and Interface Science, 268 pp. 39-63. DOI:10.1016/j.cis.2019.03.004.
  • Liu, W., Bennett, A. L., Ning, W., Tan, H., Berwanger, J. D., Zeng, X., Bruening, M. L. "Monoclonal Antibody Capture and Analysis Using Porous Membranes Containing Immobilized Peptide Mimotopes" 2018 Analytical Chemistry, 90 (20), pp. 12161-12167. DOI:10.1021/acs.analchem.8b03183.
  • Yang, L., Tang, C., Ahmad, M., Yaroshchuk, A., Bruening, M. L. "High Selectivities among Monovalent Cations in Dialysis through Cation-Exchange Membranes Coated with Polyelectrolyte Multilayers" 2018 ACS Applied Materials and Interfaces, 10 (50), pp. 44134-44143. DOI:10.1021/acsami.8b16434.
  • Liu, W., Pang, Y., Tan, H.-Y., Patel, N., Jokhadze, G., Guthals, A., Bruening, M.L. "Enzyme-containing spin membranes for rapid digestion and characterization of single proteins" 2018 Analyst, 143 (16), pp. 3907-3917. DOI: 10.1039/c8an00969d

Contact Information

Primary Research Areas

Research Specialties