Department of Chemistry & Biochemistry

Biography

2016-present

Concurrent Professor, Department of Chemistry & Biochemistry, University of Notre Dame

2016-present

Professor, Department of Chemical & Biomolecular Engineering, University of Notre Dame

2007-2016

Professor, Michigan State University

2002-2007

Associate Professor, Michigan State University

1997-2002

Assistant Professor, Michigan State University

1995-1997

NIH Postdoctoral Fellow, Texas A&M University

1995

Ph.D. in Chemistry, The Weizmann Institute of Science

1990

M.S. in Chemistry, Brigham Young University

1989

B.S. in Chemical Engineering, Brigham Young University

Selected Awards

2016

Benedetti-Pichler Award of the American Microchemical Society

2015

MSU Innovation of the Year

2014

MSU College of Natural Science Distinguished Faculty Award

2000

Society for Electroanalytical Chemistry Young Investigator Award

Research Interests

The Bruening Group develops new thin films for specific protein capture in porous membranes, ion separations in electrodialysis, and controlled protein digestion prior to analysis with mass spectrometry. Potential applications include protein purification, antibody characterization and sequencing, and salt purification or recycling.

Recent Publications

• Ding, D.; Yaroshchuk, A. and Bruening, M. L. "Electrodialysis through Nafion Membranes Coated with Polyelectrolyte Multilayers Yields >99% Pure Monovalent Ions at High Recoveries" 2022 Journal of Membrane Science, 647, 120294. DOI: 10.1016/j.memsci.2022.120294.
• Tan, H. Y.; Yang, J. Y.; Linnes, J. C.; Welch, C. J. and Bruening, M. L. "Quantitation of Trastuzumab and an Antibody to SARS-CoV-2 in Minutes using Affinity Membranes in 96-Well Plates" 2022 Analytical Chemistry, 94 (2), pp.884-891. DOI: 10.1021/acs.analchem.1c03654.
• Tang, C.; Bondarenko, M. P.; Yaroshchuk, A. and Bruening, M. L. "Highly Selective Ion Separations Based on Counter-Flow Electromigration in Nanoporous Membranes" 2021 Journal of Membrane Science, 638, 119684. DOI: 10.1016/j.memsci.2021.119684.
• Andrews, W. T.; Bickner, A. N.; Tobias, F.; Ryan, K. A.; Bruening, M. L. and Hummon, A. B. "Electroblotting through Enzymatic Membranes to Enhance Molecular Tissue Imaging" 2021 Journal of the American Society for Mass Spectrometry, 32 (7), pp.1689-1699. DOI: 10.1021/jasms.1c00046.
• Berwanger, J. D.; Tan, H. Y.; Jokhadze, G. and Bruening, M. L. "Determination of the Serum Concentrations of the Monoclonal Antibodies Bevacizumab, Rituximab, and Panitumumab using Porous Membranes Containing Immobilized Peptide Mimotopes" 2021 Analytical Chemistry, 93 (21), pp.7562-7570. DOI: 10.1021/acs.analchem.0c04903.
• Zhang, S. W.; Yang, L.; Ding, D.; Gao, P. C.; Fan, X. and Bruening, M. L. "Highly Rectifying Fluidic Diodes Based on Asymmetric Layer-by-Layer Nanofilms on Nanochannel Membranes" 2021 Analytical Chemistry, 93 (9), pp.4291-4298. DOI: 10.1021/acs.analchem.0c05303.