Merlin Bruening

Merlin Bruening

Thin Films for Selective Protein Separations


Concurrent Professor, Department of Chemistry & Biochemistry, University of Notre Dame
Professor, Department of Chemical & Biomolecular Engineering, University of Notre Dame
Professor, Michigan State University
Associate Professor, Michigan State University
Assistant Professor, Michigan State University
NIH Postdoctoral Fellow, Texas A&M University
Ph.D. in Chemistry, The Weizmann Institute of Science
M.S. in Chemistry, Brigham Young University
B.S. in Chemical Engineering, Brigham Young University

Selected Awards

Benedetti-Pichler Award of the American Microchemical Society
MSU Innovation of the Year
MSU College of Natural Science Distinguished Faculty Award
Society for Electroanalytical Chemistry Young Investigator Award

Research Interests

The Bruening Group develops new thin films for specific protein capture in porous membranes, ion separations in electrodialysis, and controlled protein digestion prior to analysis with mass spectrometry. Potential applications include protein purification, antibody characterization and sequencing, and salt purification or recycling.

Recent Papers

  • Liu, W., Pang, Y., Tan, H.-Y., Patel, N., Jokhadze, G., Guthals, A., Bruening, M.L. "Enzyme-containing spin membranes for rapid digestion and characterization of single proteins" 2018 Analyst, 143 (16), pp. 3907-3917. DOI: 10.1039/c8an00969d
  • Liu, W., Wijeratne, S., Yang, L., Bruening, M. "Porous star-star polyelectrolyte multilayers for protein binding" 2018 Polymer (United Kingdom), 138, pp. 267-274. DOI: 10.1016/j.polymer.2018.01.055
  • Yang, Z., Zhang, S., Tarabara, V.V., Bruening, M.L. "Aqueous Swelling of Zwitterionic Poly(sulfobetaine methacrylate) Brushes in the Presence of Ionic Surfactants" 2018 Macromolecules, 51 (3), pp. 1161-1171. DOI: 10.1021/acs.macromol.7b01830
  • Dong, J., Ning, W., Liu, W., Bruening, M.L. "Limited proteolysis in porous membrane reactors containing immobilized trypsin" 2017 Analyst, 142 (14), pp. 2578-2586. DOI: 10.1039/c7an00778g
  • Yaroshchuk, A., Bruening, M.L. "An analytical solution of the solution-diffusion-electromigration equations reproduces trends in ion rejections during nanofiltration of mixed electrolytes" 2017 Journal of Membrane Science, 523, pp. 361-372. DOI: 10.1016/j.memsci.2016.09.046
  • Zhu, Y., Ahmad, M., Yang, L., Misovich, M., Yaroshchuk, A., Bruening, M.L. "Adsorption of polyelectrolyte multilayers imparts high monovalent/divalent cation selectivity to aliphatic polyamide cation-exchange membranes" 2017 Journal of Membrane Science, 537, pp. 177-185. DOI: 10.1016/j.memsci.2017.05.043

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