Merlin Bruening

Merlin Bruening

Thin Films for Selective Protein Separations


Concurrent Professor, Department of Chemistry & Biochemistry, University of Notre Dame
Professor, Department of Chemical & Biomolecular Engineering, University of Notre Dame
Professor, Michigan State University
Associate Professor, Michigan State University
Assistant Professor, Michigan State University
NIH Postdoctoral Fellow, Texas A&M University
Ph.D. in Chemistry, The Weizmann Institute of Science
M.S. in Chemistry, Brigham Young University
B.S. in Chemical Engineering, Brigham Young University

Selected Awards

Benedetti-Pichler Award of the American Microchemical Society
MSU Innovation of the Year
MSU College of Natural Science Distinguished Faculty Award
Society for Electroanalytical Chemistry Young Investigator Award

Research Interests

The Bruening Group develops new thin films for specific protein capture in porous membranes, ion separations in electrodialysis, and controlled protein digestion prior to analysis with mass spectrometry. Potential applications include protein purification, antibody characterization and sequencing, and salt purification or recycling.

Recent Papers

  • Ahmad, M., Tang, C., Yang, L., Yaroshchuk, A., Bruening, M. L. "Layer-by-layer modification of aliphatic polyamide anion-exchange membranes to increase Cl-/SO42- selectivity" 2019 Journal of Membrane Science, 578 pp. 209-219. DOI:10.1016/j.memsci.2019.02.018.
  • Feroz, H., Meisenhelter, J., Jokhadze, G., Bruening, M., Kumar, M. "Rapid screening and scale-up of ultracentrifugation-free, membrane-based procedures for purification of His-tagged membrane proteins" 2019 Biotechnology Progress, DOI:10.1002/btpr.2859.
  • Yaroshchuk, A., Bruening, M. L., Zholkovskiy, E. "Modelling nanofiltration of electrolyte solutions" 2019 Advances in Colloid and Interface Science, 268 pp. 39-63. DOI:10.1016/j.cis.2019.03.004.
  • Liu, W., Bennett, A. L., Ning, W., Tan, H., Berwanger, J. D., Zeng, X., Bruening, M. L. "Monoclonal Antibody Capture and Analysis Using Porous Membranes Containing Immobilized Peptide Mimotopes" 2018 Analytical Chemistry, 90 (20), pp. 12161-12167. DOI:10.1021/acs.analchem.8b03183.
  • Yang, L., Tang, C., Ahmad, M., Yaroshchuk, A., Bruening, M. L. "High Selectivities among Monovalent Cations in Dialysis through Cation-Exchange Membranes Coated with Polyelectrolyte Multilayers" 2018 ACS Applied Materials and Interfaces, 10 (50), pp. 44134-44143. DOI:10.1021/acsami.8b16434.
  • Liu, W., Pang, Y., Tan, H.-Y., Patel, N., Jokhadze, G., Guthals, A., Bruening, M.L. "Enzyme-containing spin membranes for rapid digestion and characterization of single proteins" 2018 Analyst, 143 (16), pp. 3907-3917. DOI: 10.1039/c8an00969d

Contact Information

Primary Research Areas

Research Specialties