Department of Chemistry & Biochemistry

Biography

2016-present

Concurrent Professor, Department of Chemistry & Biochemistry, University of Notre Dame

2016-present

Professor, Department of Chemical & Biomolecular Engineering, University of Notre Dame

2007-2016

Professor, Michigan State University

2002-2007

Associate Professor, Michigan State University

1997-2002

Assistant Professor, Michigan State University

1995-1997

NIH Postdoctoral Fellow, Texas A&M University

1995

Ph.D. in Chemistry, The Weizmann Institute of Science

1990

M.S. in Chemistry, Brigham Young University

1989

B.S. in Chemical Engineering, Brigham Young University

Selected Awards

2016

Benedetti-Pichler Award of the American Microchemical Society

2015

MSU Innovation of the Year

2014

MSU College of Natural Science Distinguished Faculty Award

2000

Society for Electroanalytical Chemistry Young Investigator Award

Research Interests

The Bruening Group develops new thin films for specific protein capture in porous membranes, ion separations in electrodialysis, and controlled protein digestion prior to analysis with mass spectrometry. Potential applications include protein purification, antibody characterization and sequencing, and salt purification or recycling.

Recent Papers

• Ahmad, M., Tang, C., Yang, L., Yaroshchuk, A., Bruening, M. L. "Layer-by-layer modification of aliphatic polyamide anion-exchange membranes to increase Cl^-/SO₄^2- selectivity" 2019 Journal of Membrane Science, 578 pp. 209-219. DOI:10.1016/j.memsci.2019.02.018.
• Feroz, H., Meisenhelter, J., Jokhadze, G., Bruening, M., Kumar, M. "Rapid screening and scale-up of ultracentrifugation-free, membrane-based procedures for purification of His-tagged membrane proteins" 2019 Biotechnology Progress, DOI:10.1002/btpr.2859.
• Yaroshchuk, A., Bruening, M. L., Zholkovskiy, E. "Modelling nanofiltration of electrolyte solutions" 2019 Advances in Colloid and Interface Science, 268 pp. 39-63. DOI:10.1016/j.cis.2019.03.004.
• Liu, W., Bennett, A. L., Ning, W., Tan, H., Berwanger, J. D., Zeng, X., Bruening, M. L. "Monoclonal Antibody Capture and Analysis Using Porous Membranes Containing Immobilized Peptide Mimotopes" 2018 Analytical Chemistry, 90 (20), pp. 12161-12167. DOI:10.1021/acs.analchem.8b03183.
• Yang, L., Tang, C., Ahmad, M., Yaroshchuk, A., Bruening, M. L. "High Selectivities among Monovalent Cations in Dialysis through Cation-Exchange Membranes Coated with Polyelectrolyte Multilayers" 2018 ACS Applied Materials and Interfaces, 10 (50), pp. 44134-44143. DOI:10.1021/acsami.8b16434.
• Liu, W., Pang, Y., Tan, H.-Y., Patel, N., Jokhadze, G., Guthals, A., Bruening, M.L. "Enzyme-containing spin membranes for rapid digestion and characterization of single proteins" 2018 Analyst, 143 (16), pp. 3907-3917. DOI: 10.1039/c8an00969d