Merlin Bruening

Merlin Bruening

Thin Films for Selective Protein Separations

Biography

2016-present
Concurrent Professor, Department of Chemistry & Biochemistry, University of Notre Dame
2016-present
Professor, Department of Chemical & Biomolecular Engineering, University of Notre Dame
2007-2016
Professor, Michigan State University
2002-2007
Associate Professor, Michigan State University
1997-2002
Assistant Professor, Michigan State University
1995-1997
NIH Postdoctoral Fellow, Texas A&M University
1995
Ph.D. in Chemistry, The Weizmann Institute of Science
1990
M.S. in Chemistry, Brigham Young University
1989
B.S. in Chemical Engineering, Brigham Young University

Selected Awards

2016
Benedetti-Pichler Award of the American Microchemical Society
2015
MSU Innovation of the Year
2014
MSU College of Natural Science Distinguished Faculty Award
2000
Society for Electroanalytical Chemistry Young Investigator Award

Research Interests

The Bruening Group develops new thin films for specific protein capture in porous membranes, ion separations in electrodialysis, and controlled protein digestion prior to analysis with mass spectrometry. Potential applications include protein purification, antibody characterization and sequencing, and salt purification or recycling.

Recent Papers

  • Liu, W., Pang, Y., Tan, H.-Y., Patel, N., Jokhadze, G., Guthals, A., Bruening, M.L. "Enzyme-containing spin membranes for rapid digestion and characterization of single proteins" 2018 Analyst, 143 (16), pp. 3907-3917. DOI: 10.1039/c8an00969d
  • Liu, W., Wijeratne, S., Yang, L., Bruening, M. "Porous star-star polyelectrolyte multilayers for protein binding" 2018 Polymer (United Kingdom), 138, pp. 267-274. DOI: 10.1016/j.polymer.2018.01.055
  • Yang, Z., Zhang, S., Tarabara, V.V., Bruening, M.L. "Aqueous Swelling of Zwitterionic Poly(sulfobetaine methacrylate) Brushes in the Presence of Ionic Surfactants" 2018 Macromolecules, 51 (3), pp. 1161-1171. DOI: 10.1021/acs.macromol.7b01830
  • Dong, J., Ning, W., Liu, W., Bruening, M.L. "Limited proteolysis in porous membrane reactors containing immobilized trypsin" 2017 Analyst, 142 (14), pp. 2578-2586. DOI: 10.1039/c7an00778g
  • Yaroshchuk, A., Bruening, M.L. "An analytical solution of the solution-diffusion-electromigration equations reproduces trends in ion rejections during nanofiltration of mixed electrolytes" 2017 Journal of Membrane Science, 523, pp. 361-372. DOI: 10.1016/j.memsci.2016.09.046
  • Zhu, Y., Ahmad, M., Yang, L., Misovich, M., Yaroshchuk, A., Bruening, M.L. "Adsorption of polyelectrolyte multilayers imparts high monovalent/divalent cation selectivity to aliphatic polyamide cation-exchange membranes" 2017 Journal of Membrane Science, 537, pp. 177-185. DOI: 10.1016/j.memsci.2017.05.043

Contact Information

Primary Research Areas

Research Specialties