Department of Chemistry & Biochemistry

Biography

2021-present

Concurrent Associate Professor, Department of Chemistry & Biochemistry, University of Notre Dame

2021-present

Associate Professor, Department of Chemical & Biomolecular Engineering, University of Notre Dame

2017-2021

Concurrent Assistant Professor, Department of Chemistry & Biochemistry, University of Notre Dame

2016-2021

Assistant Professor, Department of Chemical & Biomolecular Engineering, University of Notre Dame

2012-2016

NIH NRSA Postdoctoral Fellow, Koch Institute, MIT

2011

Ph.D. in Biomedical Engineering, Northwestern University

2009

M.S. in Biomedical Engineering, Northwestern University

2006

B.S. in Chemical Engineering, University of Notre Dame

Selected Awards

2013

NIH Ruth L. Kirschstein National Research Service Award

2012

Dudley Childress Award

2011

American Heart Association Featured Chicago Researcher

Research Interests

Using principles based in supramolecular chemistry – that is, “chemistry beyond the molecule” – the Webber Lab is interested in exploiting specific, dynamic interactions between molecules to facilitate improved therapeutics. With this design inspiration, we are modulating the association and self-assembly of oligopeptides in order to create tailored and dynamic matrices for applications in regenerative medicine. We are also using specific, high affinity host-guest macrocycle chemistry to enable precise targeting and transport of drugs and therapeutic agents. Finally, we are generating new classes of recombinant materials using protein-derived affinity motifs to promote three-dimensional structures. In sum, our work aims to leverage the engineering of supramolecular motifs to improve the practice of medicine.

Recent Publications

• Webber, M. J. and Tibbitt, M. W. "Dynamic and Reconfigurable Materials from Reversible Network Interactions" 2022 Nature Reviews Materials, in press. DOI: 10.1038/s41578-021-00412-x.
• Webber, M. J. "Dynamic Soft Materials as Tough as Glass" 2022 Nature Materials, 21 (1), pp.6-7. DOI: 10.1038/s41563-021-01176-z.
• Addonizio, C. J.; Gates, B. D. and Webber, M. J. "Supramolecular "Click Chemistry" for Targeting in the Body" 2021 Bioconjugate Chemistry, 32 (9), pp.1935-1946. DOI: 10.1021/acs.bioconjchem.1c00326.
• Maikawa, C. L.; D'Aquino, A. I.; Vuong, E. T.; Su, B.; Zou, L.; Chen, P. C.; Nguyen, L. T.; Autzen, A.; Mann, J. L.; Webber, M. J. and Appel, E. A. "Affinity-Directed Dynamics of Host-Guest Motifs for Pharmacokinetic Modulation Via Supramolecular PEGylation" 2021 Biomacromolecules, 22 (8), pp.3565-3573. DOI: 10.1021/acs.biomac.1c00648.
• Yu, S. H.; Xian, S. J.; Ye, Z.; Pramudya, I. and Webber, M. J. "Glucose-Fueled Peptide Assembly: Glucagon Delivery Via Enzymatic Actuation" 2021 Journal of the American Chemical Society, 143 (32), pp.12578-12589. DOI: 10.1021/jacs.1c04570.
• Webber, M. J. and Pashuck, E. T. "(Macro)Molecular Self-Assembly for Hydrogel Drug Delivery" 2021 Advanced Drug Delivery Reviews, 172, pp.275-295. DOI: 10.1016/j.addr.2021.01.006.