- Concurrent Assistant Professor, Department of Chemistry & Biochemistry, University of Notre Dame
- Assistant Professor, Department of Chemical & Biomolecular Engineering, University of Notre Dame
- NIH NRSA Postdoctoral Fellow, Koch Institute, MIT
- Ph.D. in Biomedical Engineering, Northwestern University
- M.S. in Biomedical Engineering, Northwestern University
- B.S. in Chemical Engineering, University of Notre Dame
- NIH Ruth L. Kirschstein National Research Service Award
- Dudley Childress Award
- American Heart Association Featured Chicago Researcher
Using principles based in supramolecular chemistry – that is, “chemistry beyond the molecule” – the Webber Lab is interested in exploiting specific, dynamic interactions between molecules to facilitate improved therapeutics. With this design inspiration, we are modulating the association and self-assembly of oligopeptides in order to create tailored and dynamic matrices for applications in regenerative medicine. We are also using specific, high affinity host-guest macrocycle chemistry to enable precise targeting and transport of drugs and therapeutic agents. Finally, we are generating new classes of recombinant materials using protein-derived affinity motifs to promote three-dimensional structures. In sum, our work aims to leverage the engineering of supramolecular motifs to improve the practice of medicine.
- Braegelman, A. S., Webber, M. J. "Integrating stimuli–responsive properties in host–guest supramolecular drug delivery systems" 2019 Theranostics, 9 (11), pp. 3017-3040. DOI:10.7150/thno.31913.
- Sahoo, J. K., VandenBerg, M. A., Ruiz Bello, E. E., Nazareth, C. D., Webber, M. J. "Electrostatic-driven self-sorting and nanostructure speciation in self-assembling tetrapeptides" 2019 Nanoscale, 11 (35), pp. 16534-16543. DOI:10.1039/c9nr03440d.
- Sis, M. J., Webber, M. J. "Drug Delivery with Designed Peptide Assemblies" 2019 Trends in Pharmacological Sciences, DOI:10.1016/j.tips.2019.08.003.
- VandenBerg, M. A., Webber, M. J. "Biologically Inspired and Chemically Derived Methods for Glucose-Responsive Insulin Therapy" 2019 Advanced Healthcare Materials, 8 (12), DOI:10.1002/adhm.201801466.
- Zou, L., Braegelman, A. S., Webber, M. J. "Spatially Defined Drug Targeting by in Situ Host-Guest Chemistry in a Living Animal" 2019 ACS Central Science, 5 (6), pp. 1035-1043. DOI:10.1021/acscentsci.9b00195.
- Zou, L., Webber, M. J. "Reversible hydrogel dynamics by physical-chemical crosslink photoswitching using a supramolecular macrocycle template" 2019 Chemical Communications, 55 (67), pp. 9931-9934. DOI:10.1039/c9cc04748d.