
Matthew Webber
Concurrent Assistant Professor
Biography
- 2017-present
- Concurrent Assistant Professor, Department of Chemistry & Biochemistry, University of Notre Dame
- 2016-present
- Assistant Professor, Department of Chemical & Biomolecular Engineering, University of Notre Dame
- 2012-2016
- NIH NRSA Postdoctoral Fellow, Koch Institute, MIT
- 2011
- Ph.D. in Biomedical Engineering, Northwestern University
- 2009
- M.S. in Biomedical Engineering, Northwestern University
- 2006
- B.S. in Chemical Engineering, University of Notre Dame
Selected Awards
- 2013
- NIH Ruth L. Kirschstein National Research Service Award
- 2012
- Dudley Childress Award
- 2011
- American Heart Association Featured Chicago Researcher
Research Interests
Using principles based in supramolecular chemistry – that is, “chemistry beyond the molecule” – the Webber Lab is interested in exploiting specific, dynamic interactions between molecules to facilitate improved therapeutics. With this design inspiration, we are modulating the association and self-assembly of oligopeptides in order to create tailored and dynamic matrices for applications in regenerative medicine. We are also using specific, high affinity host-guest macrocycle chemistry to enable precise targeting and transport of drugs and therapeutic agents. Finally, we are generating new classes of recombinant materials using protein-derived affinity motifs to promote three-dimensional structures. In sum, our work aims to leverage the engineering of supramolecular motifs to improve the practice of medicine.
Recent Papers
- Maikawa, C. L., Smith, A. A. A., Zou, L., Roth, G. A., Gale, E. C., Stapleton, L. M., Baker, S. W., Mann, J. L., Yu, A. C., Correa, S., Grosskopf, A. K., Liong, C. S., Meis, C. M., Chan, D., Troxell, M., Maahs, D. M., Buckingham, B. A., Webber, M. J., Appel, E. A. "A co-formulation of supramolecularly stabilized insulin and pramlintide enhances mealtime glucagon suppression in diabetic pigs" 2020 Nature Biomedical Engineering, 4 (5), pp. 507-517. DOI:10.1038/s41551-020-0555-4.
- Sahoo, J. K., VandenBerg, M. A., Webber, M. J. "Kinetic Evolution in Metal-Dependent Self-Assembly of Peptide–Terpyridine Conjugates" 2020 Macromolecular Rapid Communications, 41 (3), 1900565. DOI:10.1002/marc.201900565.
- Vandenberg, M. A., Sahoo, J. K., Zou, L., McCarthy, W., Webber, M. J. "Divergent Self-Assembly Pathways to Hierarchically Organized Networks of Isopeptide-Modified Discotics under Kinetic Control" 2020 ACS Nano, 14 (5), pp. 5491-5505. DOI:10.1021/acsnano.9b09610.
- Xiong, X., Blakely, A., Karra, P., Vandenberg, M. A., Ghabash, G., Whitby, F., Zhang, Y. W., Webber, M. J., Holland, W. L., Hill, C. P., Chou, D. H. -. "Novel four-disulfide insulin analog with high aggregation stability and potency" 2020 Chemical Science, 11 (1), pp. 195-200. DOI:10.1039/c9sc04555d.
- Zou, L., Addonizio, C. J., Su, B., Sis, M. J., Braegelman, A. S., Liu, D., Webber, M. J. "Supramolecular Hydrogels via Light-Responsive Homoternary Cross-Links" 2020 Biomacromolecules, in press. DOI:10.1021/acs.biomac.0c00950.
- Zou, L., Vandenberg, M. A., Webber, M. J. "Single-molecule nanoscale drug carriers with quantitative supramolecular loading" 2020 Molecular Systems Design and Engineering, 5 (1), pp. 197-204. DOI:10.1039/c9me00088g.
Contact Information
- Concurrent Assistant Professor
- Office: 205B McCourtney Hall
- Phone: 574-631-4246
- Send an email
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