Matthew Webber

Matthew Webber

Supramolecular Engineering

Biography

2021-present
Concurrent Associate Professor, Department of Chemistry & Biochemistry, University of Notre Dame
2021-present
Associate Professor, Department of Chemical & Biomolecular Engineering, University of Notre Dame
2017-2021
Concurrent Assistant Professor, Department of Chemistry & Biochemistry, University of Notre Dame
2016-2021
Assistant Professor, Department of Chemical & Biomolecular Engineering, University of Notre Dame
2012-2016
NIH NRSA Postdoctoral Fellow, Koch Institute, MIT
2011
Ph.D. in Biomedical Engineering, Northwestern University
2009
M.S. in Biomedical Engineering, Northwestern University
2006
B.S. in Chemical Engineering, University of Notre Dame

Selected Awards

2013
NIH Ruth L. Kirschstein National Research Service Award
2012
Dudley Childress Award
2011
American Heart Association Featured Chicago Researcher

Research Interests

Using principles based in supramolecular chemistry – that is, “chemistry beyond the molecule” – the Webber Lab is interested in exploiting specific, dynamic interactions between molecules to facilitate improved therapeutics. With this design inspiration, we are modulating the association and self-assembly of oligopeptides in order to create tailored and dynamic matrices for applications in regenerative medicine. We are also using specific, high affinity host-guest macrocycle chemistry to enable precise targeting and transport of drugs and therapeutic agents. Finally, we are generating new classes of recombinant materials using protein-derived affinity motifs to promote three-dimensional structures. In sum, our work aims to leverage the engineering of supramolecular motifs to improve the practice of medicine.

Recent Publications

  • Webber, M. J. and Tibbitt, M. W. "Dynamic and Reconfigurable Materials from Reversible Network Interactions" 2022 Nature Reviews Materials, in press. DOI: 10.1038/s41578-021-00412-x.
  • Webber, M. J. "Dynamic Soft Materials as Tough as Glass" 2022 Nature Materials, 21 (1), pp.6-7. DOI: 10.1038/s41563-021-01176-z.
  • Addonizio, C. J.; Gates, B. D. and Webber, M. J. "Supramolecular "Click Chemistry" for Targeting in the Body" 2021 Bioconjugate Chemistry, 32 (9), pp.1935-1946. DOI: 10.1021/acs.bioconjchem.1c00326.
  • Maikawa, C. L.; D'Aquino, A. I.; Vuong, E. T.; Su, B.; Zou, L.; Chen, P. C.; Nguyen, L. T.; Autzen, A.; Mann, J. L.; Webber, M. J. and Appel, E. A. "Affinity-Directed Dynamics of Host-Guest Motifs for Pharmacokinetic Modulation Via Supramolecular PEGylation" 2021 Biomacromolecules, 22 (8), pp.3565-3573. DOI: 10.1021/acs.biomac.1c00648.
  • Yu, S. H.; Xian, S. J.; Ye, Z.; Pramudya, I. and Webber, M. J. "Glucose-Fueled Peptide Assembly: Glucagon Delivery Via Enzymatic Actuation" 2021 Journal of the American Chemical Society, 143 (32), pp.12578-12589. DOI: 10.1021/jacs.1c04570.
  • Webber, M. J. and Pashuck, E. T. "(Macro)Molecular Self-Assembly for Hydrogel Drug Delivery" 2021 Advanced Drug Delivery Reviews, 172, pp.275-295. DOI: 10.1016/j.addr.2021.01.006.

 

Contact Information

Primary Research Areas

Research Specialties