Matthew Webber

Matthew Webber

Concurrent Assistant Professor


Concurrent Assistant Professor, Department of Chemistry & Biochemistry, University of Notre Dame
Assistant Professor, Department of Chemical & Biomolecular Engineering, University of Notre Dame
NIH NRSA Postdoctoral Fellow, Koch Institute, MIT
Ph.D. in Biomedical Engineering, Northwestern University
M.S. in Biomedical Engineering, Northwestern University
B.S. in Chemical Engineering, University of Notre Dame

Selected Awards

NIH Ruth L. Kirschstein National Research Service Award
Dudley Childress Award
American Heart Association Featured Chicago Researcher

Research Interests

Using principles based in supramolecular chemistry – that is, “chemistry beyond the molecule” – the Webber Lab is interested in exploiting specific, dynamic interactions between molecules to facilitate improved therapeutics. With this design inspiration, we are modulating the association and self-assembly of oligopeptides in order to create tailored and dynamic matrices for applications in regenerative medicine. We are also using specific, high affinity host-guest macrocycle chemistry to enable precise targeting and transport of drugs and therapeutic agents. Finally, we are generating new classes of recombinant materials using protein-derived affinity motifs to promote three-dimensional structures. In sum, our work aims to leverage the engineering of supramolecular motifs to improve the practice of medicine.

Recent Papers

  • Sahoo, J.K., VandenBerg, M.A., Webber, M.J. "Injectable network biomaterials via molecular or colloidal self-assembly" 2018 Advanced Drug Delivery Reviews, 127, pp. 185-207. DOI: 10.1016/j.addr.2017.11.005
  • Webber, M.J., Langer, R. "Drug delivery by supramolecular design" 2017 Chemical Society Reviews, 46 (21), pp. 6600-6620. DOI: 10.1039/c7cs00391a
  • Sahoo, J.K., Nazareth, C., Vandenberg, M.A., Webber, M.J. "Self-assembly of amphiphilic tripeptides with sequence-dependent nanostructure" 2017 Biomaterials Science, 5 (8), pp. 1526-1530. DOI: 10.1039/c7bm00304h
  • Doloff, J.C., Veiseh, O., Vegas, A.J., Tam, H.H., Farah, S., Ma, M., Li, J., Bader, A., Chiu, A., Sadraei, A., Aresta-Dasilva, S., Griffin, M., Jhunjhunwala, S., Webber, M., Siebert, S., Tang, K., Chen, M., Langan, E., Dholokia, N., Thakrar, R., Qi, M., Oberholzer, J., Greiner, D.L., Langer, R., Anderson, D.G. "Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates" 2017 Nature Materials, 16 (6), pp. 671-680. DOI: 10.1038/nmat4866
  • Yesilyurt, V., Veiseh, O., Doloff, J.C., Li, J., Bose, S., Xie, X., Bader, A.R., Chen, M., Webber, M.J., Vegas, A.J., Langer, R., Anderson, D.G. "A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings" 2017 Advanced Healthcare Materials, 6 (4), 1601091. DOI: 10.1002/adhm.201601091
  • Webber, M.J., Appel, E.A., Vinciguerra, B., Cortinas, A.B., Thapa, L.S., Jhunjhunwala, S., Isaacs, L., Langer, R., Anderson, D.G. "Supramolecular PEGylation of biopharmaceuticals" 2016 Proceedings of the National Academy of Sciences of the United States of America, 113 (50), pp. 14189-14194. DOI: 10.1073/pnas.1616639113

Contact Information

Primary Research Areas

Research Specialties