- Associate Professor, University of Notre Dame
- Concurrent Associate Professor, Department of Physics, University of Notre Dame
- Assistant Professor, University of Notre Dame
- Senior Investigator, Structural Biology and Biophysics, Vertex Pharmaceuticals
- Postdoctoral Fellow, ETH-Zürich, Switzerland
- Ph.D. in Molecular Biophysics, University of Michigan
- B.S. in Applied and Engineering Physics, Cornell University
- Edmund P. Joyce Award for Excellence in Undergraduate Teaching
- Damon Runyon-Walter Winchell Cancer Research Fund Postdoctoral Fellowship
- Molecular Biophysics Predoctoral Training Fellowship
Biophysics, NMR Spectroscopy, Protein and Ligand Dynamics
The Peng Lab works at the interface of the physical and biological sciences to illuminate the role of bio-molecular dynamics in molecular recognition and evolution.
Our main experimental tool is multi-dimensional NMR. We focus on both methods development, and applications to several proteins of therapeutic interest. Our long term interests include: (i) getting a fundamental understanding of signal transduction and protein evolution that includes conformational ensembles and dynamics. This has relevance for understanding protein-protein interaction networks and drug resistance; (ii) new methods for including flexibility information in iterative drug design. We complement our NMR studies with molecular dynamics calculations, protein biochemistry, and collaborations with groups focused on medicinal chemistry.
- Zhang, M., Frederick, T. E., VanPelt, J., Case, D. A., Peng, J. W. "Coupled intra- And interdomain dynamics support domain cross-talk in Pin1" 2020 Journal of Biological Chemistry, 295 (49), pp. 16585-16603. DOI:10.1074/jbc.RA120.015849.
- Stoffel, S., Zhang, Q. -., Li, D. -., Smith, B. D., Peng, J. W. "NMR Relaxation Dispersion Reveals Macrocycle Breathing Dynamics in a Cyclodextrin-based Rotaxane" 2020 Journal of the American Chemical Society, 142 (16), pp. 7413-7424. DOI:10.1021/jacs.9b12524.
- Born, A., Nichols, P. J., Henen, M. A., Chi, C. N., Strotz, D., Bayer, P., Tate, S., Peng, J. W., Vögeli, B. "Backbone and side-chain chemical shift assignments of full-length, apo, human Pin1, a phosphoprotein regulator with interdomain allostery" 2019 Biomolecular NMR Assignments, 13 (1), pp. 85-89. DOI:10.1007/s12104-018-9857-9.
- Zhang, M., Case, D. A., Peng, J. W. "Propagated Perturbations from a Peripheral Mutation Show Interactions Supporting WW Domain Thermostability" 2018 Structure, 26 (11), pp. 1474-1485.e5. DOI:10.1016/j.str.2018.07.014.
- Bouchard, J.J., Xia, J., Case, D.A., Peng, J.W. "Enhanced Sampling of Interdomain Motion Using Map-Restrained Langevin Dynamics and NMR: Application to Pin1" 2018 Journal of Molecular Biology, 430 (14), pp. 2164-2180. DOI: 10.1016/j.jmb.2018.05.007
- Frederick, T.E., Peng, J.W. "A gratuitous β-Lactamase inducer uncovers hidden active site dynamics of the Staphylococcus aureus BlaR1 sensor domain" 2018 PLoS ONE, 13 (5), e0197241. DOI: 10.1371/journal.pone.0197241.