Jeffrey W. Peng

Jeffrey W. Peng

Biophysics NMR Methods and Biomolecular Dynamics

Biography

2010-present
Associate Professor, University of Notre Dame
2010-present
Concurrent Associate Professor, Department of Physics, University of Notre Dame
2003-2010
Assistant Professor, University of Notre Dame
1994-2003
Senior Investigator, Structural Biology and Biophysics, Vertex Pharmaceuticals
1993-1994
Postdoctoral Fellow, ETH-Zürich, Switzerland
1993
Ph.D. in Molecular Biophysics, University of Michigan
1987
B.S. in Applied and Engineering Physics, Cornell University

Selected Awards

2011
Edmund P. Joyce Award for Excellence in Undergraduate Teaching
1993-1994
Damon Runyon-Walter Winchell Cancer Research Fund Postdoctoral Fellowship
1989-1991
Molecular Biophysics Predoctoral Training Fellowship

Research Interests

Biophysics, NMR Spectroscopy, Protein and Ligand Dynamics

The Peng Lab works at the interface of the physical and biological sciences to illuminate the role of bio-molecular dynamics in molecular recognition and evolution. 

Our main experimental tool is multi-dimensional NMR. We focus on both methods development, and applications to several proteins of therapeutic interest. Our long term interests include: (i) getting a fundamental understanding of signal transduction and protein evolution that includes conformational ensembles and dynamics. This has relevance for understanding protein-protein interaction networks and drug resistance; (ii) new methods for including flexibility information in iterative drug design. We complement our NMR studies with molecular dynamics calculations, protein biochemistry, and collaborations with groups focused on medicinal chemistry.

Recent Papers

  • Bouchard, J.J., Xia, J., Case, D.A., Peng, J.W. "Enhanced Sampling of Interdomain Motion Using Map-Restrained Langevin Dynamics and NMR: Application to Pin1" 2018 Journal of Molecular Biology, 430 (14), pp. 2164-2180. DOI: 10.1016/j.jmb.2018.05.007
  • Frederick, T.E., Peng, J.W. "A gratuitous β-Lactamase inducer uncovers hidden active site dynamics of the Staphylococcus aureus BlaR1 sensor domain" 2018 PLoS ONE, 13 (5), e0197241. DOI: 10.1371/journal.pone.0197241
  • Mahoney, B.J., Zhang, M., Zintsmaster, J.S., Peng, J.W. "Extended Impact of Pin1 Catalytic Loop Phosphorylation Revealed by S71E Phosphomimetic" 2018 Journal of Molecular Biology, 430 (5), pp. 710-721. DOI: 10.1016/j.jmb.2017.12.021
  • Massi, F., Peng, J.W. "Characterizing protein dynamics with NMR R1ρ relaxation experiments" 2018 Methods in Molecular Biology, 1688, pp. 205-221. DOI: 10.1007/978-1-4939-7386-6_10
  • Staude, M.W., Leonard, D.A., Peng, J.W. "Expanded Substrate Activity of OXA-24/40 in Carbapenem-Resistant Acinetobacter baumannii Involves Enhanced Binding Loop Flexibility" 2016 Biochemistry, 55 (47), pp. 6535-6544. DOI: 10.1021/acs.biochem.6b00806
  • Wang, X., Mahoney, B.J., Zhang, M., Zintsmaster, J.S., Peng, J.W. "Negative Regulation of Peptidyl-Prolyl Isomerase Activity by Interdomain Contact in Human Pin1" 2015 Structure, 23 (12), pp. 2224-2233. DOI: 10.1016/j.str.2015.08.019

Contact Information

  • Associate Professor
  • Office: 450 Stepan Chemistry Hall
  • Phone: 574-631-2983
  • Send an email

Primary Research Areas

Research Specialties