- Director, Notre Dame Radiation Laboratory
- Professor, University of Notre Dame
- Professional Specialist, Notre Dame Radiation Laboratory
- Associate Professional Specialist, Notre Dame Radiation Laboratory
- Assistant Professional Specialist, Notre Dame Radiation Laboratory
- Research Associate, Notre Dame Radiation Laboratory
- British Royal Society Research Fellow, University of Amsterdam, Netherlands
- Ph.D. in Physical and Theoretical Chemistry, University of Glasgow, Scotland
- B.Sc. in Chemistry, University of Glasgow, Scotland
Ionizing radiation pervades our environment and affects all life on earth. The absorption of this impinging energy produces profound chemical and biochemical transformations in the materials irradiated. Professor Carmichael's research provides a fundamental molecular-level understanding of these radiation effects in matter.
The work is performed in the Notre Dame Radiation Laboratory, the premier facility for radiation chemical research in the US, supported by the Chemical Sciences Division of Basic Energy Sciences at the US Department of Energy. The NDRL provides not only access to unique experimental tools but also outstanding research opportunities for focused interdisciplinary collaborations. Knowledge gained from this research provides the scientific basis for solving problems ranging from the chemical conversion of solar energy, through nuclear energy production, environmental waste management and remediation, to biomedical radiation therapy.
Specific topics currently under active investigation include:
Radiation damage in protein crystallography
Understanding and mitigating radiation damage during macromolecular crystallography at synchrotrons
Electron-driven processes in condensed phases
Excited species in water radiolysis; radical formation in irradiated organic liquids
Radiation effects in heterogeneous systems and at interfaces
Characterizing radiation chemistry at water - ceramic oxide interfaces
Spin coupling in biomolecular NMR
Probing conformational and chemical changes in carbohydrates
- Bugris, V., Harmat, V., Ferenc, G., Brockhauser, S., Carmichael, I., Garman, E. F. "Radiation-damage investigation of a DNA 16-mer" 2019 Journal of Synchrotron Radiation, 26 pp. 998-1009. DOI:10.1107/S160057751900763X.
- Li, Z., Ryszka, M., Dawley, M. M., Carmichael, I., Bravaya, K. B., Ptasińska, S. "Dipole-Supported Electronic Resonances Mediate Electron-Induced Amide Bond Cleavage" 2019 Physical Review Letters, 122 (7), DOI:10.1103/PhysRevLett.122.073002.
- Zhang, W., Meredith, R., Pan, Q., Wang, X., Woods, R. J., Carmichael, I., Serianni, A. S. "Use of Circular Statistics to Model αman-(1→2)-αMan and αman-(1→3)-α/βMan O-Glycosidic Linkage Conformation in 13 C-Labeled Disaccharides and High-Mannose Oligosaccharides" 2019 Biochemistry, 58 (6), pp. 546-560. DOI:10.1021/acs.biochem.8b01050.
- Zhang, W., Meredith, R., Yoon, M. -., Wang, X., Woods, R. J., Carmichael, I., Serianni, A. S. "Synthesis and O-Glycosidic Linkage Conformational Analysis of 13C-Labeled Oligosaccharide Fragments of an Antifreeze Glycolipid" 2019 Journal of Organic Chemistry, 84 (4), pp. 1706-1724. DOI:10.1021/acs.joc.8b01411.
- Li, Z., Carmichael, I., Ptasińska, S. "Dissociative electron attachment induced ring opening in five-membered heterocyclic compounds" 2018 Physical Chemistry Chemical Physics, 20 (27), pp. 18271-18278. DOI: 10.1039/C8CP02718H
- Li, Z., Milosavljević, A.R., Carmichael, I., Ptasinska, S. "Characterization of Neutral Radicals from a Dissociative Electron Attachment Process" 2017 Physical Review Letters, 119 (5), 053402. DOI: 10.1103/PhysRevLett.119.053402