Evgenii Kovrigin
Research Professor; Director, Magnetic Resonance Research Center
- Office
- 280 Stepan Chemistry
Notre Dame, IN 46556 - Phone
- +1 574-631-8359
- ekovrigu@nd.edu
Research Areas
- Physical/Analytical Chemistry
Research Specialties
- Measurement
Prospective Graduate Students
Biography
| Year | Title |
|---|---|
| 2018-present | Director, Magnetic Resonance Research Center, University of Notre Dame |
| 2025-present | Research Professor, University of Notre Dame |
| 2018-2025 | Associate Research Professor, University of Notre Dame |
| 2011-2018 | Assistant Professor of Chemistry, Marquette University |
| 2006-2011 | Assistant Professor of Biochemistry, Medical College of Wisconsin |
| 2001-2006 | Postdoctoral Fellow, Yale University |
| 2000-2001 | Postdoctoral Fellow, UT Southwestern Medical Center - Dallas |
| 1999-2000 | Postdoctoral Scientist, Institute of Protein Research, Russia |
| 1999 | Ph.D. in Chemistry, Engelhardt Institute of Molecular Biology, Russia |
| 1995 | M.Sci. in Molecular Biology, Moscow State University, Russia |
| 1993 | B.Sci. in Chemistry, Krasnoyarsk State University, Russia |
Selected Awards
2026 College of Science Outstanding Research Service Award
2012, 2014 Summer Faculty Fellowship, Marquette University
2001 Anderson Postdoctoral Fellowship, Yale University
1999 MicroCal Young Scientist Award
Research Interests
Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful method to interrogate small and large molecules at the atomic level. In chemistry and biochemistry, NMR spectroscopy allows one to determine structure and conformation of molecules as well as to monitor their dynamic changes in the course of chemical reactions. NMR signals are also sensitive to subtle interactions between molecules, providing a unique window into the molecular interaction mechanisms. Biological polymers such as proteins and nucleic acids often undergo complex multi-step rearrangements between different conformations to accommodate their ligandsâreadily followed by the NMR spectroscopy to reveal their functional significance.
The Magnetic Resonance Research Center is a state-of-the-art NMR facility serving inorganic, organic, and biological chemists and material scientists at the University of Notre Dame and beyond. Seven NMR instruments ranging from 300 to 800 MHz are available for use by students, postdocs, and faculty for solution and solid-state NMR experiments. The Center provides individualized user training and supports continuous development of advanced NMR pulse programs and software for NMR data analysis to facilitate competitive cutting-edge research.
Selected Publications
- Waugh, J. B.; Redko, M.; Jin, X. Y.; Muldoon, G.; Kovrigin, E. L.; Gallant, B. M.; Li, Y. Z.; Liu, G. and Muldoon, J. "Overcoming Misconceptions in Lithium Metal Polymer Electrolyte Batteries" 2025 Energy & Environmental Science, 18 (21), pp.9312–9323. DOI: 10.1039/d5ee03530a.
- Kadu, P.; Webber, B.; Chen, W. K.; Kovrigin, E. L. and Webber, M. J. "Mechanistic Insights for Glucose-Driven Coacervation of a Supramolecular Peptide and Therapeutic Protein" 2025 ACS Applied Materials & Interfaces, 17 (29), pp.41696–41706. DOI: 10.1021/acsami.5c07167.
- Torres-Cadena, R.; Dayaratne, W.; Chen, H. T.; Kovrigin, E. L.; Tucker, M. G.; Haberl, B. and Jaffe, A. "Negative Compressibility Transitions in Hybrid Metal Oxides" 2025 Journal of the American Chemical Society, 147 (29), pp.25931–25939. DOI: 10.1021/jacs.5c08464.
- Ma, J. Q.; Ayres, C. M.; Brambley, C. A.; Chandran, S. S.; Rosales, T. J.; Perera, W.; Eldaly, B.; Murray, W. T.; Corcelli, S. A.; Kovrigin, E. L.; Klebanoff, C. A. and Baker, B. M. "Dynamic Allostery in the Peptide/MHC Complex Enables TCR Neoantigen Selectivity" 2025 Nature Communications, 16 (1), 849. DOI: 10.1038/s41467-025-56004-8.
- Manu, V. S.; Melacini, G.; Kovrigin, E. L.; Loria, J. P. and Veglia, G. "Unbiased Clustering of Residues Undergoing Synchronous Motions in Proteins using NMR Spin Relaxation Data" 2025 Biophysical Chemistry, 320, 107411. DOI: 10.1016/j.bpc.2025.107411.
- Chen, Y. S.; Kozlov, G.; Fakih, R.; Yang, M.; Zhang, Z. D.; Kovrigin, E. L. and Gehring, K. "Mg2+-ATP Sensing in CNNM, a Putative Magnesium Transporter" 2020 Structure, 28 (3), pp.324. DOI: 10.1016/j.str.2019.11.016.