Bradley D. Smith

Bradley D. Smith

Bioorganic & Supramolecular Chemistry


Emil T. Hofman Professor of Science, University of Notre Dame
Director, Notre Dame Integrated Imaging Facility
Professor, University of Notre Dame
Associate Professor, University of Notre Dame
Assistant Professor, University of Notre Dame
Postdoctoral Fellow, Columbia University
Postdoctoral Fellow, Oxford University, UK
Ph.D. in Chemistry, Pennsylvania State University
B.Sc. in Chemistry, University of Melbourne, Australia

Selected Awards

Harold Kohn Endowed Distinguished Alumni Lecturer, The Pennsylvania State University
Fellow, Royal Society of Chemistry
Fellow, American Association for the Advancement of Science
Visiting Fellow, Japan Society for Promotion of Science
Kaneb Outstanding Undergraduate Teaching Award

Research Interests

SMART MOLECULES FOR IMAGING, TARGETING, AND HEALTH (SMITH). The specific research projects are diverse and encompass topics such as organic synthesis, membrane biophysics, photonics, and small animal imaging. A major aim is to develop novel molecular imaging probes that can detect dying cells in culture, and tumors and bacterial infection in living animals. Some of the fluorescent imaging probes are commercially available. They help accelerate the pre-clinical stages of drug discovery and development, and also enable new strategies for studying the biology of human disease. The probes may eventually be employed in humans for fluorescence guided surgery. A notable discovery is a family of interlocked molecules called squaraine-rotaxanes which have many potential applications as extremely bright and stable fluorescent Near-IR dyes. An offshoot of this work is the development of new methods of achieving laser-induced photothermolysis for biomedical imaging and therapeutic applications.


Recent Publications

  • Shaffer, C. C.; Oliver, A. G. and Smith, B. D. "Co-Crystals of Tetrachloroauric Acid and 1,3,5-(Methylacetamide)Benzene-Based Tectons: Consistent Trapping of High Energy Molecular Conformation" 2022 Crystengcomm, 24 (21), pp.3879-3885. DOI: 10.1039/d2ce00463a.
  • Morsby, J. J. and Smith, B. D. "Advances in Optical Sensors of N-Acetyl-Beta-D-Hexosaminidase (N-Acetyl-Beta-D-Glucosaminidase)" 2022 Bioconjugate Chemistry, 33 (4), pp.544-554. DOI: 10.1021/acs.bioconjchem.2c00057.
  • Morsby, J. J.; Atkinson, K. M.; Kommidi, S. R.; Freel, T.; Janekova, H.; Stacko, P. and Smith, B. D. "Structure-Activity Studies of Nitroreductase-Responsive Near-Infrared Heptamethine Cyanine Fluorescent Probes" 2022 European Journal of Organic Chemistry, 23, e202200270. DOI: 10.1002/ejoc.202200270.
  • Morsby, J. J.; Thimes, R. L.; Olson, J. E.; McGarraugh, H. H.; Payne, J. N.; Camden, J. P. and Smith, B. D. "Enzyme Sensing using 2-Mercaptopyridine-Carbonitrile Reporters and Surface-Enhanced Raman Scattering" 2022 ACS Omega, 7 (7), pp.6419-6426. DOI: 10.1021/acsomega.2c00139.
  • Dharmarwardana, M.; Dempsey, J. M.; Padilla-Coley, S.; Jarvis, T. S.; Shi, K. J.; Atkinson, K. M. and Smith, B. D. "Supramolecular Capture of Highly Polar Amidosquaraine Dye in Water with Nanomolar Affinity and Large Turn-on Fluorescence" 2021 Chemical Communications, 57 (99), pp.13518-13521. DOI: 10.1039/d1cc05039g.
  • Gamage, R. S.; Li, D. H.; Schreiber, C. L. and Smith, B. D. "Comparison of cRGDfK Peptide Probes with Appended Shielded Heptamethine Cyanine Dye (s775z) for Near Infrared Fluorescence Imaging of Cancer" 2021 ACS Omega, 6 (44), pp.30130-30139. DOI: 10.1021/acsomega.1c04991.


Contact Information

  • Emil T. Hofman Professor of Science; Director, Notre Dame Integrated Imaging Facility
  • Office: 340N McCourtney Hall
  • Phone: 574-631-8632
  • Send an email
  • Visit Website

Primary Research Areas

Research Specialties