Bradley D. Smith

Bradley D. Smith

Bioorganic & Supramolecular Chemistry


Emil T. Hofman Chair, University of Notre Dame
Director, Notre Dame Integrated Imaging Facility
Professor, University of Notre Dame
Associate Professor, University of Notre Dame
Assistant Professor, University of Notre Dame
Postdoctoral Fellow, Columbia University
Postdoctoral Fellow, Oxford University, UK
Ph.D. in Chemistry, Pennsylvania State University
B.Sc. in Chemistry, University of Melbourne, Australia

Selected Awards

Fellow, Royal Society of Chemistry
Fellow, American Association for the Advancement of Science
Visiting Fellow, Japan Society for Promotion of Science
Kaneb Outstanding Undergraduate Teaching Award

Research Interests

SMART MOLECULES FOR IMAGING, TARGETING, AND HEALTH (SMITH). The specific research projects are diverse and encompass topics such as organic synthesis, membrane biophysics, photonics, and small animal imaging. A major aim is to develop novel molecular imaging probes that can detect dying cells in culture, and tumors and bacterial infection in living animals. Some of the fluorescent imaging probes are commercially available. They help accelerate the pre-clinical stages of drug discovery and development, and also enable new strategies for studying the biology of human disease. The probes may eventually be employed in humans for fluorescence guided surgery. A notable discovery is a family of interlocked molecules called squaraine-rotaxanes which have many potential applications as extremely bright and stable fluorescent Near-IR dyes. An offshoot of this work is the development of new methods of achieving laser-induced photothermolysis for biomedical imaging and therapeutic applications.


Recent Papers

  • Liu, W., McGarraugh, H.H., Smith, B.D. "Fluorescent thienothiophene-containing squaraine dyes and threaded supramolecular complexes with tunable wavelengths between 600–800 nm" 2018 Molecules, 23 (9), 2229. DOI: 10.3390/molecules23092229
  • Liu, W., Oliver, A.G., Smith, B.D. "Macrocyclic Receptor for Precious Gold, Platinum, or Palladium Coordination Complexes" 2018 Journal of the American Chemical Society, 140 (22), pp. 6810-6813. DOI: 10.1021/jacs.8b04155
  • Shaw, S.K., Schreiber, C.L., Roland, F.M., Battles, P.M., Brennan, S.P., Padanilam, S.J., Smith, B.D. "High expression of integrin αvβ3 enables uptake of targeted fluorescent probes into ovarian cancer cells and tumors" 2018 Bioorganic and Medicinal Chemistry, 26 (8), pp. 2085-2091. DOI: 10.1016/j.bmc.2018.03.007
  • Zhang, Q.-W., Zajíček, J., Smith, B.D. "Cyclodextrin Rotaxane with Switchable Pirouetting" 2018 Organic Letters, 20 (7), pp. 2096-2099. DOI: 10.1021/acs.orglett.8b00655
  • Liu, W., Johnson, A., Smith, B.D. "Guest Back-Folding: A Molecular Design Strategy That Produces a Deep-Red Fluorescent Host/Guest Pair with Picomolar Affinity in Water" 2018 Journal of the American Chemical Society, 140 (9), pp. 3361-3370. DOI: 10.1021/jacs.7b12991
  • Schreiber, C.L., Smith, B.D. "Molecular Imaging of Aminopeptidase N in Cancer and Angiogenesis" 2018 Contrast Media and Molecular Imaging, 2018, 5315172. DOI: 10.1155/2018/5315172

Contact Information

  • Emil T. Hofman Professor of Chemistry and Biochemistry
  • Office: 340N McCourtney Hall
  • Phone: 574-631-8632
  • Send an email
  • Visit Website

Primary Research Areas

Research Specialties