Bradley D. Smith

Bradley D. Smith

Bioorganic & Supramolecular Chemistry


Emil T. Hofman Chair, University of Notre Dame
Director, Notre Dame Integrated Imaging Facility
Professor, University of Notre Dame
Associate Professor, University of Notre Dame
Assistant Professor, University of Notre Dame
Postdoctoral Fellow, Columbia University
Postdoctoral Fellow, Oxford University, UK
Ph.D. in Chemistry, Pennsylvania State University
B.Sc. in Chemistry, University of Melbourne, Australia

Selected Awards

Fellow, Royal Society of Chemistry
Fellow, American Association for the Advancement of Science
Visiting Fellow, Japan Society for Promotion of Science
Kaneb Outstanding Undergraduate Teaching Award

Research Interests

SMART MOLECULES FOR IMAGING, TARGETING, AND HEALTH (SMITH). The specific research projects are diverse and encompass topics such as organic synthesis, membrane biophysics, photonics, and small animal imaging. A major aim is to develop novel molecular imaging probes that can detect dying cells in culture, and tumors and bacterial infection in living animals. Some of the fluorescent imaging probes are commercially available. They help accelerate the pre-clinical stages of drug discovery and development, and also enable new strategies for studying the biology of human disease. The probes may eventually be employed in humans for fluorescence guided surgery. A notable discovery is a family of interlocked molecules called squaraine-rotaxanes which have many potential applications as extremely bright and stable fluorescent Near-IR dyes. An offshoot of this work is the development of new methods of achieving laser-induced photothermolysis for biomedical imaging and therapeutic applications.


Recent Papers

  • Harmatys, K. M.; Battles, P. M.; Peck, E. M.; Spence, G. T.; Roland, F. M.; Smith, B. D. "Selective photothermal inactivation of cells labeled with near-infrared croconaine dye." Chem. Commun. 2017, 53, 9906-9909.
  • Shaw, S. K.; Liu, W.; Brennan, S. P.; Betancourt-Mendiola, M. d. L.; Smith, B. D. "Non-Covalent Assembly Method that Simultaneously Endows a Liposome Surface with Targeting Ligands, Protective PEG Chains, and Deep-Red Fluorescence Reporter Groups." Chem.-Eur. J. 2017, 23, 12646-12654.
  • Gomez-Duran, C. F. A.; Liu, W.; Betancourt-Mendiola, M. d. L.; Smith, B. D. "Structural Control of Kinetics for Macrocycle Threading by Fluorescent Squaraine Dye in Water." J. Org. Chem. 2017, 82, 8334-8341.
  • Jarvis, T. S.; Collins, C. G.; Dempsey, J. M.; Oliver, A. G.; Smith, B. D. "Synthesis and Structure of 3,3-Dimethylindoline Squaraine Rotaxanes." J. Org. Chem. 2017, 82, 5819-5825.
  • Rice, D. R.; Mendiola, M. d. L. B.; Murillo-Solano, C.; Checkley, L. A.; Ferdig, M. T.; Pizarro, J. C.; Smith, B. D. "Antiplasmodial activity of targeted zinc(II)-dipicolylamine complexes." Bioorg. Med. Chem. 2017, 25, 2754-2760.
  • Liu, W.; Gomez-Duran, C. F. A.; Smith, B. D. "Fluorescent Neuraminidase Assay Based on Supramolecular Dye Capture After Enzymatic Cleavage." J. Am. Chem. Soc. 2017, 139, 6390-6395.

Contact Information

Primary Research Areas

Research Specialties