Department of Chemistry & Biochemistry

Biography

2021-present

Professor, Dept. of Chemical & Biomolecular Engineering, University of Notre Dame

2021-present

Concurrent Professor, Dept. of Chemistry & Biochemistry, University of Notre Dame

2015-2021

Associate Professor, Dept. of Chemical & Biomolecular Engineering, University of Notre Dame

2015-2021

Concurrent Associate Professor, Dept. of Chemistry & Biochemistry, University of Notre Dame

2008-2015

Assistant Professor, Dept. of Chemical & Biomolecular Engineering, University of Notre Dame

2008-2015

Concurrent Assistant Professor, Dept. of Chemistry & Biochemistry, University of Notre Dame

2005-2008

Postdoctoral Fellow, Harvard University

2005

Ph.D. in Chemistry, Tufts University

1998

B.S. in Chemistry, Bogazici University, Turkey

Research Interests

Multivalent biomolecular interactions are very important in biological systems. A deeper understanding of the thermodynamics and kinetics of multivalent interactions in biological systems is imperative in the development of new diagnostic and therapeutic agents. My lab focuses on both understanding the basic dynamic principles of multivalent biomolecular interactions, as well as design of multivalent therapeutic and diagnostic molecules which will deliver novel solutions to complex diseases (e.g. cancer, autoimmune diseases, and allergies).

Recent Publications

• Mejia, F.; Khan, S. and Bilgicer, B. "Liposomal Targeting Modifies Endosomal Escape: Design and Mechanistic Implications" 2022 ACS Biomaterials Science & Engineering, 8 (3), pp.1067-1073. DOI: 10.1021/acsbiomaterials.2c00100.
• Mejia, F.; Khan, S.; Omstead, D. T.; Minetos, C. and Bilgicer, B. "Identification and Optimization of Tunable Endosomal Escape Parameters for Enhanced Efficacy in Peptide-Targeted Prodrug-Loaded Nanoparticles" 2022 Nanoscale, 14 (4), pp.1226-1240. DOI: 10.1039/d1nr05357d.
• Omstead, D. T.; Mejia, F.; Sjoerdsma, J.; Kim, B.; Shin, J.; Khan, S.; Wu, J. M.; Kiziltepe, T.; Littlepage, L. E. and Bilgicer, B. "In Vivo Evaluation of CD38 and CD138 as Targets for Nanoparticle-Based Drug Delivery in Multiple Myeloma" 2020 Journal of Hematology & Oncology, 13 (1), 145. DOI: 10.1186/s13045-020-00965-4.
• Kim, B.; Shin, J.; Wu, J.; Omstead, D. T.; Kiziltepe, T.; Littlepage, L. E. and Bilgicer, B. "Engineering Peptide -Targeted Liposomal Nanoparticles Optimized for Improved Selectivity for HER2-Positive Breast Cancer Cells to Achieve Enhanced in Vivo Efficacy" 2020 Journal of Controlled Release, 322, pp.530-541. DOI: 10.1016/j.jconrel.2020.04.010.
• Kim, B.; Shin, J.; Kiziltepe, T. and Bilgicer, B. "Identification of a Moderate Affinity CD22 Binding Peptide and in Vitro Optimization of Peptide-Targeted Nanoparticles for Selective Uptake by CD22+B-Cell Malignancies" 2020 Nanoscale, 12 (21), pp.11672-11683. DOI: 10.1039/d0nr02133d.
• Kim, B.; Shin, J. and Bilgicer, B. "How could Nanoallergen Technology be used as a Diagnostic Tool for Allergies?" 2020 Nanomedicine, 15 (11), pp.1063-1066. DOI: 10.2217/nnm-2020-0055.