Arnaldo Serrano

Arnaldo Serrano

Nonlinear and Multidimensional Spectroscopy


2017 - present
Assistant Professor, University of Notre Dame
2013 - 2017
Postdoctoral Fellow, University of Wisconsin, Madison
Ph.D. in Chemistry, University of Pennsylvania
B.A. in Chemistry, Rutgers University

Selected Awards

ACS PHYS Division Postdoctoral Research Award
Hans Neurath Outstanding Promise Award

Research Interests

Femtosecond nonlinear and multidimensional spectroscopies provide windows into an array of molecular properties not available to more conventional optical techniques. By employing these methods as microscopies, new types of image contrast become possible. Research in the Serrano group will focus on both developing these new nonlinear imaging modes as well as using them to characterize structure and dynamics in heterogeneous environments. Other problems of interest include measuring the interaction of drug molecules with protein targets using visible pump-infrared probe spectroscopy and characterizing the effect of macromolecular crowders, which mimic cellular environment, on the kinetics of protein aggregation using multidimensional infrared spectroscopy.

Recent Papers

  • Serrano, A.L., Lomont, J.P., Tu, L.-H., Raleigh, D.P., Zanni, M.T. "A Free Energy Barrier Caused by the Refolding of an Oligomeric Intermediate Controls the Lag Time of Amyloid Formation by hIAPP" 2017 Journal of the American Chemical Society, 139 (46), pp. 16748-16758. DOI: 10.1021/jacs.7b08830
  • Kratochvil, H.T., Carr, J.K., Matulef, K., Annen, A.W., Li, H., Maj, M., Ostmeyer, J., Serrano, A.L., Raghuraman, H., Moran, S.D., Skinner, J.L., Perozo, E., Roux, B., Valiyaveetil, F.I., Zanni, M.T. "Instantaneous ion configurations in the K+ion channel selectivity filter revealed by 2D IR spectroscopy" 2016 Science, 353 (6303), pp. 1040-1044. DOI: 10.1126/science.aag1447
  • Ostrander, J.S., Serrano, A.L., Ghosh, A., Zanni, M.T. "Spatially Resolved Two-Dimensional Infrared Spectroscopy via Wide-Field Microscopy" 2016 ACS Photonics, 3 (7), pp. 1315-1323. DOI: 10.1021/acsphotonics.6b00297
  • Ghosh, A., Serrano, A.L., Oudenhoven, T.A., Ostrander, J.S., Eklund, E.C., Blair, A.F., Zanni, M.T. "Experimental implementations of 2D IR spectroscopy through a horizontal pulse shaper design and a focal plane array detector" 2016 Optics Letters, 41 (3), pp. 524-527. DOI: 10.1364/OL.41.000524
  • Serrano, A.L., Ghosh, A., Ostrander, J.S., Zanni, M.T. "Wide-field FTIR microscopy using mid-IR pulse shaping" 2015 Optics Express, 23 (14), pp. 17815-17827. DOI: 10.1364/OE.23.017815
  • Ghosh, A., Ho, J.-J., Serrano, A.L., Skoff, D.R., Zhang, T., Zanni, M.T. "Two-dimensional sum-frequency generation (2D SFG) spectroscopy: Summary of principles and its application to amyloid fiber monolayers" 2015 Faraday Discussions, 177, pp. 493-505. DOI: 10.1039/c4fd00173g

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Research Specialties