Aktar Ali

Aktar Ali

Associate Research Professor

Biography

2021-present
Associate Research Professor & Director, Biological Screening Core, Warren Family Center for Drug Discovery, University of Notre Dame
2018-2021
Adjunct Teaching Faculty, Richland College
2017-2021
Co-Director, Mineral Metabolism Laboratory, University of Texas Southwestern Medical Center
2015-2017
Assistant Professor & Core Director, Biomedical & Obesity Research Core, University of Nebraska
2008-2015
Assistant Professor & Core Director, Metabolic Phenotyping Core, University of Texas Southwestern Medical Center
2005-2007
Instructor, University of Texas Southwestern Medical Center
2003-2005
Associate Research Scientist, Department of Pathology, NYU School of Medicine
2000-2003
Assistant Research Scientist, Nelson Institute of Environmental Medicine, NYU School of Medicine
1999
Postdoctoral Fellow, Niigata University of Pharmacy and Applied Life Science, Japan
1999
Ph.D. in Pharmaceutical Science, Niigata University of Pharmacy and Applied Life Science, Japan
1994
M.Sc. in Inorganic Chemistry, University of Chittagong, Bangladesh
1991
B.Sc. in Chemistry, University of Chittagong, Bangladesh

Recent Publications

  • Deng, Y., Wang, Z. V., Gordillo, R., Zhu, Y., Ali, A., Zhang, C., Wang, X., Shao, M., Zhang, Z., Iyengar, P., Gupta, R. K., Horton, J. D., Hill, J. A., Scherer, P. E. "Adipocyte Xbp1s overexpression drives uridine production and reduces obesity" 2018 Molecular Metabolism, 11 pp. 1-17. DOI:10.1016/j.molmet.2018.02.013.
  • Tsunezumi, J., Sugiura, H., Oinam, L., Ali, A., Thang, B. Q., Sada, A., Yamashiro, Y., Kuro-O, M., Yanagisawa, H. "Fibulin-7, a heparin binding matricellular protein, promotes renal tubular calcification in mice" 2018 Matrix Biology, 74 pp. 5-20. DOI:10.1016/j.matbio.2018.04.014.
  • Hasan, M., Gonugunta, V. K., Dobbs, N., Ali, A., Palchik, G., Calvaruso, M. A., DeBerardinis, R. J., Yan, N. "Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism" 2017 Proceedings of the National Academy of Sciences of the United States of America, 114 (4), pp. 746-751. DOI:10.1073/pnas.1611113114.
  • Wang, Q. A., Tao, C., Jiang, L., Shao, M., Ye, R., Zhu, Y., Gordillo, R., Ali, A., Lian, Y., Holland, W. L., Gupta, R. K., Scherer, P. E. "Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation" 2015 Nature Cell Biology, 17 (9), pp. 1099-1111. DOI:10.1038/ncb3217.
  • Moore, Z., Chakrabarti, G., Luo, X., Ali, A., Hu, Z., Fattah, F. J., Vemireddy, R., DeBerardinis, R. J., Brekken, R. A., Boothman, D. A. "NAMPT inhibition sensitizes pancreatic adenocarcinoma cells to tumor-selective, PAR-independent metabolic catastrophe and cell death induced by β-lapachone" 2015 Cell Death and Disease, 6 (1), e1599. DOI:10.1038/cddis.2014.564.
  • Chakrabarti, G., Moore, Z.R., Luo, X., Ilcheva, M., Ali, M. A., Fattah, F. J., Padanad, M., Zhou, Y., Xie, Y., Lyssiotis, C., Scaglioni, P. P., Kimmelman, A., DeBerardinis, R. J., Cantley, L., Boothman, D. A. "Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone" 2015 Cancer & Metabolism, 3, 12. DOI:10.1186/s40170-015-0137-1.

Contact Information

  • Associate Research Professor
  • Office: 305B McCourtney Hall
  • Phone: 574-631-2363
  • Send an email

Primary Research Areas

Research Specialties