News » Archives » October 2013

Notre Dame research finding may help accelerate diabetic wound healing

Author: William G. Gilroy

Mobashery Lab

University of Notre Dame researchers have, for the first time, identified the enzymes that are detrimental to diabetic wound healing and those that are beneficial to repair the wound.

There are currently no therapeutics for diabetic wound healing. The current standard of care is palliative to keep the wound clean and free of infection. In the United States, 66,000 diabetic individuals each year undergo lower-limb amputations due to wounds that failed to heal.

Read More

Prashant Kamat presents work on low-cost solar cell alternatives

Author: Gene Stowe

Prashant Kamat

Recently Prashant V. Kamat, the Rev. John A Zahm C.S.C. Professor of Science, gave a presentation on low-cost solar-cell alternatives at the annual American Chemical Society meeting in Indianapolis.

Scientists have been searching for ways to make low-cost solar cells—photovoltaic devices that convert light to electricity. Solar-cell technology isn’t new, but the high cost of producing the technology makes it difficult for wide use.…

Read More

Notre Dame researchers uncover keys to antibiotic resistance in MRSA

Author: Marissa Gebhard

Methicillin-resistant Staphylococcus aureus (MRSA) is shown in the background (in gray). This figure depicts domains and key ligands of the penicillin binding protein 2a — a key resistance enzyme. The red molecule on the right is ceftaroline, a drug recently approved by the FDA.

University of Notre Dame researchers Shahriar Mobashery, Mayland Chang, their team members, and their collaborators in Spain have published research results this week that show how methicillin-resistant Staphylococcus aureus (MRSA) regulates the critical crosslinking of its cell wall in the face of beta-lactam antibiotics.

The work, published in the Proceedings of the National Academy of Sciences, reveals the mechanistic basis for how the MRSA bacterium became such a difficult pathogen over the previous 50 years, in which time it spread rapidly across the world.

Read More