Shahriar Mobashery

Navari Family Professor in Life Sciences

354B Mccourtney Hall
Notre Dame, IN 46556
+1 574-631-2933

Research Areas

  • Biochemistry
  • Organic Chemistry

Research Specialties

  • Life Processes
  • Medicine
  • Synthesis

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Year Title
2003-present Navari Family Professor in Life Sciences, University of Notre Dame
1997-2003 Professor, Wayne State University
1994-1997 Associate Professor, Wayne State University
1989-1994 Assistant Professor, Wayne State University
1986-1988 Postdoctoral Research Associate, Rockefeller University
1985 Ph.D. in Chemistry, University of Chicago
1981 B.S. in Chemistry, University of Southern California
1980 B.S. in Biological Sciences, University of Southern California

Selected Awards

2019   Emil Thomas Kaiser Award

2014-2016   Fellow, Science Without Borders, Brazil

2012   Research Achievement Award, University of Notre Dame

2007   Astellas USA Foundation Award of the American Chemical Society

2007   Fellow, America Association for the Advancement of Science

1999-2001   Charles H. Gershenson Distinguished Faculty Fellow

Prof. Mobashery CV

Research Interests

The Mobashery research program integrates computation, biochemistry, molecular biology, and the organic synthesis of medically important molecules. Bringing together these different disciplines is desirable to produce both scientific and medical advances for difficult, but critically important clinical problems.

Bacterial Antibiotic Resistance, Cell Wall and Discovery of Novel Antibiotics

The studies of antibiotics and antibiotic resistance are central themes in the Mobashery laboratory. Mechanisms of resistance to β-lactam antibiotics have been studied, with a focus on methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa as two nefarious human bacterial pathogens. A multidisciplinary approach is taken towards elucidating the distinct strategies that nature has devised to counter the use of antibiotics in the clinic. Significant work has also been directed towards the bacterial cell wall. The cell wall is a structure that encases the entire organism, and it is critically important for its survival. Its complex biosynthesis and recycling are subjects of study. Discovery of novel antibacterials is another large focus of attention.

Diseases of the Extracellular Matrix

The Mobashery laboratory is interested in diseases of the extracellular matrix (ECM). The ECM is an environment that surrounds every cell in higher organisms. There are many proteins and carbohydrates within this environment, whose homeostasis is highly regulated. When these regulatory processes break down, many disparate diseases ensue. The Mobashery lab investigates how these diseases develop and progress, and designs novel therapeutics for their intervention. The diseases of matrix of interest in the Mobashery lab include diabetes, pulmonary fibrosis, traumatic-brain injury and stroke.

Selected Publications

  • El-Araby, A. M.; Jiménez-Faraco, E.; Feltzer, R.; Martin-Garcia, J. M.; Karri, B. R.; Ramachandran, B.; Kim, C.; Fisher, J. F.; Hermoso, J. A. and Mobashery, S. "Catalytic Process of Anhydro-N-Acetylmuramic Acid Kinase from Pseudomonas Aeruginosa" 2023 Journal of Biological Chemistry, 299 (10), 105198. DOI: 10.1016/j.jbc.2023.105198.
  • Avila-Cobian, L. F.; Hoshino, H.; Horsman, M. E.; Nguyen, V. T.; Qian, Y. Y.; Feltzer, R.; Kim, C.; Hu, D. D.; Champion, M. M.; Fisher, J. F. and Mobashery, S. "Amber-Codon Suppression for Spatial Localization and in Vivo Photoaffinity Capture of the Interactome of the Pseudomonas Aeruginosa Rare Lipoprotein A Lytic Transglycosylase" 2023 Protein Science, 32 (10), e4781. DOI: 10.1002/pro.4781.
  • Qian, Y. Y.; Birhanu, B. T.; Yang, J. D.; Ding, D. R.; Janardhanan, J.; Mobashery, S. and Chang, M. "A Potent and Narrow-Spectrum Antibacterial Against Clostridioides Difficile Infection" 2023 Journal of Medicinal Chemistry, 66 (20), pp.13891-13899. DOI: 10.1021/acs.jmedchem.3c01249.
  • Martinez-Caballero, S.; Freton, C.; Molina, R.; Bartual, S. G.; Gueguen-Chaignon, V.; Mercy, C.; Gago, F.; Mahasenan, K. V.; Munoz, I. G.; Lee, M.; Hesek, D.; Mobashery, S.; Hermoso, J. A. and Grangeasse, C. "Molecular Basis of the Final Step of Cell Division in Streptococcus pneumoniae" 2023 Cell Reports, 42, 112756. DOI: 10.1016/j.celrep.2023.112756.
  • Janardhanan, J.; Kim, C.; Qian, Y.; Yang, J.  Meisel, J. E.; Ding, D.; Speri, E.; Schroeder, V. A.; Wolter, W. R.; Oliver, A. G.; Mobashery, S. and Chang, M. Y. "A Dual-Action Antibiotic That Kills Clostridioides difficile Vegetative Cells and Inhibits Spore Germination" 2023 Proceedings of the National Academy of Sciences of the United States of America, 120 (20), e2304110120. DOI: 10.1073/pnas.2304110120.
  • Avila-Cobian, L. F.; De Benedetti, S.; Kim, C.; Feltzer, R.; Champion, M. M.; Fisher, J. F. and Mobashery, S. "In Vitro Studies of the Protein-Interaction Network of Cell-Wall Lytic Transglycosylase RlpA of Pseudomonas Aeruginosa" 2022 Communications Biology, 5 (1), 1314. DOI: 10.1038/s42003-022-04230-x.