Roberta Melander
Associate Research Professor
- Office
- 252 Mccourtney Hall
Notre Dame, IN 46556 - rmelande@nd.edu
Research Areas
- Biochemistry
Research Specialties
- Medicine
Prospective Graduate Students
Biography
| Year | Title |
|---|---|
| 2018-present | Associate Research Professor, University of Notre Dame |
| 2011-present | Editor, Chemical Biology and Drug Design |
| 2011-2018 | Research Assistant Professor, North Carolina State University |
| 2009-2011 | Postdoctoral Research Associate, North Carolina State University |
| 2008-2009 | Postdoctoral Research Associate, University College London |
| 2008 | Ph.D. in Biological Chemistry, University of Manchester |
| 2004 | M.Chem. in Medicinal Chemistry, University of Manchester Institute of Science and Technology |
Research Interests
My research centers on using small molecules to study and control bacterial behaviors. I am interested in developing molecules that mediate: antibiotic resistance and tolerance, evolution of resistance to antimicrobial agents, and virulence, as potential novel therapeutic options for treating bacterial infections. I am also working to identify molecules that influence secondary metabolite production to identify novel antimicrobials.
Selected Publications
- Nemeth, A. M.; Young, M. M.; Melander, R. J.; Smith, R. D.; Ernst, R. K. and Melander, C. "Identification of a 2-Aminobenzimidazole Scaffold that Potentiates Gram-Positive Selective Antibiotics Against Gram-Negative Bacteria" 2024 ChemBioChem, 25 (8), e202400127. DOI: 10.1002/cbic.202400127.
- Li, H. T.; Nemeth, A. M.; Melander, R. J. and Melander, C. "Synthesis, Stereochemical Resolution, and Analogue Synthesis of Variabiline, an Aporphine Alkaloid that Sensitizes Acinetobacter Baumannii and Klebsiella Pneumoniae to Colistin" 2024 ACS Infectious Diseases, 10 (4), pp.1339-1350. DOI: 10.1021/acsinfecdis.4c00026.
- Crotteau, A. N.; Hubble, V. B.; Marrujo, S. A.; Mattingly, A. E.; Melander, R. J. and Melander, C. "Sensitization of Gram-Negative Bacteria to Aminoglycosides with 2-Aminoimidazole Adjuvants" 2023 Antibiotics-Basel, 12 (11), 1563. DOI: 10.3390/antibiotics12111563.
- Harper, E. I.; Siroky, M. D.; Hilliard, T. S.; Dominique, G. M.; Hammond, C.; Liu, Y. Y.; Yang, J.; Hubble, V. B.; Walsh, D. J.; Melander, R. J.; Melander, C.; Ravosa, M. J. and Stack, M. S. "Advanced Glycation End Products as a Potential Target for Restructuring the Ovarian Cancer Microenvironment: A Pilot Study" 2023 International Journal of Molecular Sciences, 24 (12), 9804. DOI: 10.3390/ijms24129804.
- Liu, C.; Zhang, H.; Peng, X.; Blackledge, M. S.; Furlani, R. E.; Li, H. T.; Su, Z. M.; Melander, R. J.; Melander, C.; Michalek, S. and Wu, H. "Small Molecule Attenuates Bacterial Virulence by Targeting Conserved Response Regulator" 2023 mBio, 14 (3), e00137-23. DOI: 10.1128/mbio.00137-23.
- Marrujo, S. A.; Hubble, V. B.; Yang, J. D.; Wang, M.; Nemeth, A. M.; Barlock, S. L.; Juarez, D.; Smith, R. D.; Melander, R. J.; Ernst, R. K.; Chang, M. Y. and Melander, C. "Dimeric 2-Aminoimidazoles are Highly Active Adjuvants for Gram-Positive Selective Antibiotics Against Acinetobacter Baumannii" 2023 European Journal of Medicinal Chemistry, 253, 115329. DOI: 10.1016/j.ejmech.2023.115329.