Merlin Bruening

Donald & Susan Rice Professor of Engineering; Concurrent Professor

140C Mccourtney Hall
Notre Dame, IN 46556
+1 574-631-3024


Research Areas

  • Physical/Analytical Chemistry

Research Specialties

  • Life Processes
  • Materials
  • Measurement

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Year Title
2019-present Donald & Susan Rice Professor of Engineering, Department of Chemical & Biomolecular Engineering, University of Notre Dame
2016-present Concurrent Professor, Department of Chemistry & Biochemistry, University of Notre Dame
2016-2019 Professor, Department of Chemical & Biomolecular Engineering, University of Notre Dame
2007-2016 Professor, Michigan State University
2002-2007 Associate Professor, Michigan State University
1997-2002 Assistant Professor, Michigan State University
1995-1997 NIH Postdoctoral Fellow, Texas A&M University
1995 Ph.D. in Chemistry, The Weizmann Institute of Science
1990 M.S. in Chemistry, Brigham Young University
1989 B.S. in Chemical Engineering, Brigham Young University

Selected Awards

2016   Benedetti-Pichler Award of the American Microchemical Society

2015   MSU Innovation of the Year

2014   MSU College of Natural Science Distinguished Faculty Award

2000   Society for Electroanalytical Chemistry Young Investigator Award

Research Interests

The Bruening Group develops new thin films for specific protein capture in porous membranes, ion separations in electrodialysis, and controlled protein digestion prior to analysis with mass spectrometry. Potential applications include protein purification, antibody characterization and sequencing, and salt purification or recycling.

Selected Publications

  • Yang, J. Y.; Ostafe, R. and Bruening, M. L. "In-Membrane Enrichment and Peptic Digestion to Facilitate Analysis of Monoclonal Antibody Glycosylation" 2024 Analytical Chemistry, 96 (16), pp.6347-6355. DOI: 10.1021/acs.analchem.4c00030.
  • Zhang, S. W.; Wang, J. F.; Yaroshchuk, A.; Du, Q. J.; Xin, P. Y.; Bruening, M. L. and Xia, F. "Addressing Challenges in Ion-Selectivity Characterization in Nanopores" 2024 Journal of the American Chemical Society, 146 (16), pp. 11036-11042. DOI: 10.1021/jacs.4c00603.
  • Ding, D.; Yang, L. Y.; Wang, J.; Yaroshchuk, A.; Schaefer, J. L. and Bruening, M. L. "Selective Transport of Trivalent Lanthanide in Electrodialysis: Limitations due to Concentration Polarization" 2023 Journal of Membrane Science, 685, 121949. DOI: 10.1016/j.memsci.2023.121949.
  • Yang, J. Y.; Ostafe, R.; Welch, C. J.; Verhalen, B.; Budyak, I. L. and Bruening, M. L. "Rapid Quantitation of various Therapeutic Monoclonal Antibodies using Membranes with Fc-Specific Ligands" 2023 Analytical Chemistry, 95 (22), pp.8541-8551. DOI: 10.1021/acs.analchem.3c00531.
  • Cao, W. K. and Bruening, M. L. "Analysis of Protein Glycosylation After Rapid Digestion using Protease-Containing Membranes in Spin Columns" 2023 Journal of the American Society for Mass Spectrometry, 34 (6), pp.1086-1095. DOI: 10.1021/jasms.3c00038.
  • Ryan, K. A. and Bruening, M. L. "Online Protein Digestion in Membranes between Capillary Electrophoresis and Mass Spectrometry" 2023 Analyst, 148 (7), pp.1611-1619. DOI: 10.1039/d3an00106g.