Merlin Bruening
Donald & Susan Rice Professor of Engineering; Concurrent Professor
- Office
- 140C Mccourtney Hall
Notre Dame, IN 46556 - Phone
- +1 574-631-3024
- mbruenin@nd.edu
Research Areas
- Physical/Analytical Chemistry
Research Specialties
- Life Processes
- Materials
- Measurement
Prospective Graduate Students
Biography
| Year | Title |
|---|---|
| 2019-present | Donald & Susan Rice Professor of Engineering, Department of Chemical & Biomolecular Engineering, University of Notre Dame |
| 2016-present | Concurrent Professor, Department of Chemistry & Biochemistry, University of Notre Dame |
| 2016-2019 | Professor, Department of Chemical & Biomolecular Engineering, University of Notre Dame |
| 2007-2016 | Professor, Michigan State University |
| 2002-2007 | Associate Professor, Michigan State University |
| 1997-2002 | Assistant Professor, Michigan State University |
| 1995-1997 | NIH Postdoctoral Fellow, Texas A&M University |
| 1995 | Ph.D. in Chemistry, The Weizmann Institute of Science |
| 1990 | M.S. in Chemistry, Brigham Young University |
| 1989 | B.S. in Chemical Engineering, Brigham Young University |
Selected Awards
2016 Benedetti-Pichler Award of the American Microchemical Society
2015 MSU Innovation of the Year
2014 MSU College of Natural Science Distinguished Faculty Award
2000 Society for Electroanalytical Chemistry Young Investigator Award
Research Interests
The Bruening Group develops new thin films for specific protein capture in porous membranes, ion separations in electrodialysis, and controlled protein digestion prior to analysis with mass spectrometry. Potential applications include protein purification, antibody characterization and sequencing, and salt purification or recycling.
Selected Publications
- Yang, J. Y.; Ostafe, R. and Bruening, M. L. "In-Membrane Enrichment and Peptic Digestion to Facilitate Analysis of Monoclonal Antibody Glycosylation" 2024 Analytical Chemistry, 96 (16), pp.6347-6355. DOI: 10.1021/acs.analchem.4c00030.
- Zhang, S. W.; Wang, J. F.; Yaroshchuk, A.; Du, Q. J.; Xin, P. Y.; Bruening, M. L. and Xia, F. "Addressing Challenges in Ion-Selectivity Characterization in Nanopores" 2024 Journal of the American Chemical Society, 146 (16), pp. 11036-11042. DOI: 10.1021/jacs.4c00603.
- Ding, D.; Yang, L. Y.; Wang, J.; Yaroshchuk, A.; Schaefer, J. L. and Bruening, M. L. "Selective Transport of Trivalent Lanthanide in Electrodialysis: Limitations due to Concentration Polarization" 2023 Journal of Membrane Science, 685, 121949. DOI: 10.1016/j.memsci.2023.121949.
- Yang, J. Y.; Ostafe, R.; Welch, C. J.; Verhalen, B.; Budyak, I. L. and Bruening, M. L. "Rapid Quantitation of various Therapeutic Monoclonal Antibodies using Membranes with Fc-Specific Ligands" 2023 Analytical Chemistry, 95 (22), pp.8541-8551. DOI: 10.1021/acs.analchem.3c00531.
- Cao, W. K. and Bruening, M. L. "Analysis of Protein Glycosylation After Rapid Digestion using Protease-Containing Membranes in Spin Columns" 2023 Journal of the American Society for Mass Spectrometry, 34 (6), pp.1086-1095. DOI: 10.1021/jasms.3c00038.
- Ryan, K. A. and Bruening, M. L. "Online Protein Digestion in Membranes between Capillary Electrophoresis and Mass Spectrometry" 2023 Analyst, 148 (7), pp.1611-1619. DOI: 10.1039/d3an00106g.