Jeffrey Peng
Associate Professor
- Office
- 450 Stepan Chemistry
Notre Dame, IN 46556 - Phone
- +1 574-631-2983
- jpeng@nd.edu
Research Areas
- Biochemistry
- Physical/Analytical Chemistry
Research Specialties
- Life Processes
- Medicine
Prospective Graduate Students
Biography
| Year | Title |
|---|---|
| 2010-present | Associate Professor, University of Notre Dame |
| 2010-present | Concurrent Associate Professor, Department of Physics, University of Notre Dame |
| 2003-2010 | Assistant Professor, University of Notre Dame |
| 1994-2003 | Senior Investigator, Structural Biology and Biophysics, Vertex Pharmaceuticals |
| 1993-1994 | Postdoctoral Fellow, ETH-Zürich, Switzerland |
| 1993 | Ph.D. in Molecular Biophysics, University of Michigan |
| 1987 | B.S. in Applied and Engineering Physics, Cornell University |
Selected Awards
2011 Edmund P. Joyce Award for Excellence in Undergraduate Teaching
1993-1994 Damon Runyon-Walter Winchell Cancer Research Fund Postdoctoral Fellowship
1989-1991 Molecular Biophysics Predoctoral Training Fellowship
Research Interests
Biophysics, NMR Spectroscopy, Protein and Ligand Dynamics
The Peng Lab works at the interface of the physical and biological sciences to illuminate the role of bio-molecular dynamics in molecular recognition and evolution.
Our main experimental tool is multi-dimensional NMR. We focus on both methods development, and applications to several proteins of therapeutic interest. Our long term interests include: (i) getting a fundamental understanding of signal transduction and protein evolution that includes conformational ensembles and dynamics. This has relevance for understanding protein-protein interaction networks and drug resistance; (ii) new methods for including flexibility information in iterative drug design. We complement our NMR studies with molecular dynamics calculations, protein biochemistry, and collaborations with groups focused on medicinal chemistry.
Selected Publications
- Ding, Y.; Zhang, Z. M.; Toso, S.; Gushchina, I.; Trepalin, V.; Shi, K. J.; Peng, J. W. and Kuno, M. "Mixed Ligand Passivation as the Origin of Near-Unity Emission Quantum Yields in CsPbBr3 Nanocrystals" 2023 Journal of the American Chemical Society, 145 (11), pp.6362-6370. DOI: 10.1021/jacs.2c13527.
- VanPelt, J.; Stoffel, S.; Staude, M. W.; Dempster, K.; Rose, H. A.; Graney, S.; Graney, E.; Braynard, S.; Kovrigina, E.; Leonard, D. A. and Peng, J. W. "Arginine Modulates Carbapenem Deactivation by OXA-24/40 in Acinetobacter Baumannii" 2021 Journal of Molecular Biology, 433 (19), 167150. DOI: 10.1016/j.jmb.2021.167150.
- Zhang, M. L.; Frederick, T. E.; VanPelt, J.; Case, D. A. and Peng, J. "Coupled Intra- and Interdomain Dynamics Support Domain Cross-Talk in Pin1" 2020 Journal of Biological Chemistry, 295 (49), pp.16585-16603. DOI: 10.1074/jbc.RA120.015849.
- Stoffel, S.; Zhang, Q. W.; Li, D. H.; Smith, B. D. and Peng, J. W. "NMR Relaxation Dispersion Reveals Macrocycle Breathing Dynamics in a Cyclodextrin-Based Rotaxane" 2020 Journal of the American Chemical Society, 142 (16), pp.7413-7424. DOI: 10.1021/jacs.9b12524.
- Born, A.; Nichols, P. J.; Henen, M. A.; Chi, C. N.; Strotz, D.; Bayer, P.; Tate, S. I.; Peng, J. W. and Vogeli, B. "Backbone and Side-Chain Chemical Shift Assignments of Full-Length, Apo, Human Pin1, a Phosphoprotein Regulator with Interdomain Allostery" 2019 Biomolecular NMR Assignments, 13 (1), pp.85-89. DOI: 10.1007/s12104-018-9857-9.
- Zhang, M. L.; Case, D. A. and Peng, J. W. "Propagated Perturbations from a Peripheral Mutation show Interactions Supporting WW Domain Thermostability" 2018 Structure, 26 (11), pp.1474. DOI: 10.1016/j.str.2018.07.014.