Matthew Webber
Keating-Crawford Collegiate Associate Professor of Engineering; Concurrent Associate Professor
- Office
- 105F McCourtney Hall
Notre Dame, IN 46556 - Phone
- +1 574-631-4246
- mwebber@nd.edu
Research Areas
- Biochemistry
Research Specialties
- Materials
- Medicine
Prospective Graduate Students
Biography
| Year | Title |
|---|---|
| 2022-present | Keating-Crawford Collegiate Associate Professor, Department of Chemical & Biomolecular Engineering, University of Notre Dame |
| 2021-present | Concurrent Associate Professor, Department of Chemistry & Biochemistry, University of Notre Dame |
| 2021-2022 | Associate Professor, Department of Chemical & Biomolecular Engineering, University of Notre Dame |
| 2017-2021 | Concurrent Assistant Professor, Department of Chemistry & Biochemistry, University of Notre Dame |
| 2016-2021 | Assistant Professor, Department of Chemical & Biomolecular Engineering, University of Notre Dame |
| 2012-2016 | NIH NRSA Postdoctoral Fellow, Koch Institute, MIT |
| 2011 | Ph.D. in Biomedical Engineering, Northwestern University |
| 2009 | M.S. in Biomedical Engineering, Northwestern University |
| 2006 | B.S. in Chemical Engineering, University of Notre Dame |
Selected Awards
2023 Owens-Corning Award, Materials Engineering & Science Division, American Institute of Chemical Engineers
2023 Elected to College of Fellows, American Institute of Medical & Biological Engineering
2022 ACS-PMSE Elected Member-at-Large
2020 NSF CAREER Award
2020 ACS-PMSE Young Investigator Award
2019 3M Non-Tenured Faculty Award
2013 NIH Ruth L. Kirschstein National Research Service Award
Research Interests
Using principles based in supramolecular chemistry – that is, “chemistry beyond the molecule” – the Webber Lab is interested in exploiting specific, dynamic interactions between molecules to facilitate improved therapeutics. With this design inspiration, we are modulating the association and self-assembly of oligopeptides in order to create tailored and dynamic matrices for applications in regenerative medicine. We are also using specific, high affinity host-guest macrocycle chemistry to enable precise targeting and transport of drugs and therapeutic agents. Finally, we are generating new classes of recombinant materials using protein-derived affinity motifs to promote three-dimensional structures. In sum, our work aims to leverage the engineering of supramolecular motifs to improve the practice of medicine.
Selected Publications
- Xiang, Y. H.; Su, B.; Liu, D. P. and Webber, M. J. "Managing Diabetes with Hydrogel Drug Delivery" 2023 Advanced Therapeutics, 2300127. DOI: 10.1002/adtp.202300127.
- Ye, Z.; Pramuyda, I.; Xiang, Y. H.; Yu, S. H.; Chi, T.; Liu, D. P.; Su, B.; Addonizio, C. J.; Xian, S. J.; Zou, L. and Webber, M. J. "Detachable Microneedles Via Host-Guest Supramolecular Polymer Networks" 2023 ACS Materials Letters, 5 (6), pp.1684-1691. DOI: 10.1021/acsmaterialslett.3c00287.
- Meudom, R.; Zhang, Y. X.; VandenBerg, M. A.; Zou, L.; Zhang, Y. W.; Webber, M. J. and Chou, D. "Supramolecular Approaches for Insulin Stabilization without Prolonged Duration of Action" 2023 Acta Pharmaceutica Sinica B, 13 (5), pp.2281-2290. DOI: 10.1016/j.apsb.2023.01.007.
- Sun, Z. H.; Fan, B. W. and Webber, M. J. "Molecular Engineering of Carbohydrate Recognition" 2023 ChemSystemsChem, e202200050. DOI: 10.1002/syst.202200050.
- Ollier, R. C.; Xiang, Y. H.; Yacovelli, A. M. and Webber, M. J. "Biomimetic Strain-Stiffening in Fully Synthetic Dynamic-Covalent Hydrogel Networks" 2023 Chemical Science, 14 (18), pp.4796-4805. DOI: 10.1039/d3sc00011g.
- Fan, B. W.; Garcia, D. T.; Salehi, M.; Webber, M. J.; van Kasteren, S. I. and Eelkema, R. "Dynamic Covalent Dextran Hydrogels as Injectable, Self-Adjuvating Peptide Vaccine Depots" 2023 ACS Chemical Biology, 18 (3), pp.652-659. DOI: 10.1021/acschembio.2c00938.