Bradley Smith

Emil T. Hofman Professor of Science; Director, Notre Dame Integrated Imaging Facility

340J Mccourtney Hall
Notre Dame, IN 46556
+1 574-631-8632


Research Areas

  • Biochemistry
  • Organic Chemistry

Research Specialties

  • Life Processes
  • Medicine
  • Synthesis

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Year Title
2008-present Emil T. Hofman Professor of Science, University of Notre Dame
2008-present Director, Notre Dame Integrated Imaging Facility
2001-2008 Professor, University of Notre Dame
1997-2001 Associate Professor, University of Notre Dame
1991-1997 Assistant Professor, University of Notre Dame
1990-1991 Postdoctoral Fellow, Columbia University
1989-1990 Postdoctoral Fellow, Oxford University, UK
1988 Ph.D. in Chemistry, Pennsylvania State University
1983 B.Sc. in Chemistry, University of Melbourne, Australia

Selected Awards

2018   Harold Kohn Endowed Distinguished Alumni Lecturer, The Pennsylvania State University

2012   Fellow, Royal Society of Chemistry

2011   Fellow, American Association for the Advancement of Science

2008   Visiting Fellow, Japan Society for Promotion of Science

2000   Kaneb Outstanding Undergraduate Teaching Award

Research Interests

SMART MOLECULES FOR IMAGING, TARGETING, AND HEALTH (SMITH). The specific research projects are diverse and encompass topics such as organic synthesis, membrane biophysics, photonics, and small animal imaging. A major aim is to develop novel molecular imaging probes that can detect dying cells in culture, and tumors and bacterial infection in living animals. Some of the fluorescent imaging probes are commercially available. They help accelerate the pre-clinical stages of drug discovery and development, and also enable new strategies for studying the biology of human disease. The probes may eventually be employed in humans for fluorescence guided surgery. A notable discovery is a family of interlocked molecules called squaraine-rotaxanes which have many potential applications as extremely bright and stable fluorescent Near-IR dyes. An offshoot of this work is the development of new methods of achieving laser-induced photothermolysis for biomedical imaging and therapeutic applications.


Selected Publications

  • Gamage, R. S.; Chasteen, J. L. and Smith, B. D. "Lipophilic Anchors that Embed Bioconjugates in Bilayer Membranes: A Review" 2023 Bioconjugate Chemistry, 34 (6), pp.961-971. DOI: 10.1021/acs.bioconjchem.3c00204.
  • Kommidi, S. and Smith, B. D. "Supramolecular Complexation of Azobenzene Dyes by Cucurbit[7]Uril" 2023 Journal of Organic Chemistry, 88 (13), pp.8431-8440. DOI: 10.1021/acs.joc.3c00423.
  • Li, D. H.; Gamage, R. S.; Oliver, A. G.; Patel, N. L.; Usama, S. M.; Kalen, J. D.; Schnermann, M. J. and Smith, B. D. "Doubly Strapped Zwitterionic NIR-I and NIR-II Heptamethine Cyanine Dyes for Bioconjugation and Fluorescence Imaging" 2023 Angewandte Chemie-International Edition, 62, e202305062. DOI: 10.1002/anie.202305062.
  • Chasteen, J. L.; Padilla-Coley, S.; Li, D. H. and Smith, B. D. "Palladium Responsive Liposomes for Triggered Release of Aqueous Contents" 2023 Bioorganic & Medicinal Chemistry Letters, 84, 129215. DOI: 10.1016/j.bmcl.2023.129215.
  • Gamage, R. S. and Smith, B. D. "Spontaneous Transfer of Indocyanine Green from Liposomes to Albumin is Inhibited by the Antioxidant α-Tocopherol" 2022 Langmuir, 38 (39), pp.11950-11961. DOI: 10.1021/acs.langmuir.2c01715.
  • Kommidi, S. and Smith, B. D. "Cucurbit[7]Uril Complexation of Near-Infrared Fluorescent Azobenzene-Cyanine Conjugates" 2022 Molecules, 27 (17), 5440. DOI: 10.3390/molecules27175440.