Anthony Serianni


428 Stepan Chemistry
Notre Dame, IN 46556
+1 574-631-7807


Research Areas

  • Biochemistry
  • Organic Chemistry

Research Specialties

  • Life Processes
  • Synthesis

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Year Title
1999-present Professor, University of Notre Dame
1988-1999 Associate Professor, University of Notre Dame
1982-1988 Assistant Professor, University of Notre Dame
1980-1982 Postdoctoral Research Associate, Cornell University
1980 Ph.D. in Biochemistry, Michigan State University
1975 B.S. in Biochemistry, Albright College

Selected Awards

2012   Fellow, Royal Society of Chemistry

2012   Fellow, American Chemical Society

2010   Fellow, American Association for the Advancement of Science

2006   Melville L. Wolfrom Award in Carbohydrate Chemistry, ACS Division of Carbohydrate Chemistry

2003   Kaneb Teaching Award

2001   John A. Boezi Memorial Alumnus Award, Michigan State University

1988   Horace S. Isbell Award in Carbohydrate Chemistry, ACS Division of Carbohydrate Chemistry

Research Interests

Professor Serianni's research focuses on the use of stable isotopically-labeled compounds to examine structure, conformation and reactivity of carbohydrates and nucleic acids in solution using modern multidimensional NMR methods and computational techniques. His group is interested in developing and improving chemical and chemi-enzymic methods to prepare carbohydrate-containing biomolecules containing one or more sites of isotopic enrichment, with 13C, 2H and 15N of primary concern. NMR studies of these labeled biomolecules permit a more detailed assessment of their 3-D structures in solution, information which is critical to understanding the fundamental factors controlling molecular recognition in biological processes.

Of current interest is the use of stable isotopes in the assessment of DNA and RNA structure in solution. Research is under way to: a) develop efficient chemical, chemi-enzymic, and/or biological methods to introduce isotopes selectively or uniformly into nucleosides and oligonucleotides, b) apply 2-D and 3-D NMR methods to decipher the NMR spectra of labeled oligonucleotides, and c) assess the merits of 13C-1H and 13C-13C spin-coupling constants within the furanose rings of RNA and DNA as structural probes. NMR data are complemented and extended by ab initio molecular orbital calculations which can assess the energetics and structural features of furanose ring pseudorotation and predict 13C-1H and 13C-13C spin-couplings for various pathways in these rings, and by X-ray crystallography. The long range objective is to apply this information to NMR solution studies of CCAAT-containing oligonucleotides involved in the NF-1 recognition site at the origin of replication of human adenovirus, and other biologically-important DNA and RNA oligomers.

Other work involves studies of carbohydrate metabolism via in vivo 13C and 19F NMR spectroscopy, and the development of automated devices for chemical and biological synthesis of labeled biomolecules.

Selected Publications

  • Meredith, R. J.; Yoon, M. K.; Carmichael, I. and Serianni, A. S. "MA'AT Analysis: Unbiased Multi-State Conformational Modeling of Exocyclic Hydroxymethyl Group Conformation in Methyl Aldohexopyranosides" 2024 Journal of Physical Chemistry B, 128 (10), pp.2360-2370. DOI: 10.1021/acs.jpcb.3c08136.
  • Zhang, W. H.; Meredith, R. J.; Wang, X. C.; Woods, R. J.; Carmichael, I. and Serianni, A. S. "Does Inter-Residue Hydrogen Bonding in Β-(1→4)-Linked Disaccharides Influence Linkage Conformation in Aqueous Solution?" 2024 Journal of Physical Chemistry B, 128 (10), pp.2317-2325. DOI: 10.1021/acs.jpcb.3c07448.
  • Meredith, R.; Zhu, Y. P.; Yoon, M. K.; Tetrault, T.; Lin, J. Y.; Zhang, W. H.; McGurn, M.; Cook, E.; Popp, R.; Shit, P.; Carmichael, I. and Serianni, A. S. "Methyl Α-D-Galactopyranosyl-(1→3)-Β-D-Galactopyranoside and Methyl Β-D-Galactopyranosyl-(1→3)-Β-D-Galactopyranoside: Glycosidic Linkage Conformation Determined from MA'AT Analysis" 2024 Magnetic Resonance in Chemistry, pp.1-12. DOI: 10.1002/mrc.5424.
  • Kim, M.; Kim, Y. and Serianni, A. S. "NMR Structural Study of Syndecan-4 Transmembrane Domain with Cytoplasmic Region" 2023 Molecules, 28 (23), 7855. DOI: 10.3390/molecules28237855.
  • Meredith, R. J.; Carmichael, I.; Woods, R. J. and Serianni, A. S. "MA'AT Analysis: Probability Distributions of Molecular Torsion Angles in Solution from NMR Spectroscopy" 2023 Accounts of Chemical Research, 56 (17), pp.2313-2328. DOI: 10.1021/acs.accounts.3c00286.
  • Tetrault, T.; Meredith, R. J.; Yoon, M. K.; Canizares, C.; Oliver, A. G.; Carmichael, I. and Serianni, A. S. "One-Bond C-13-C-13 Spin-Coupling Constants in Saccharides: A Comparison of Experimental and Calculated Values by Density Functional Theory using Solid-State C-13 NMR and X-Ray Crystallography" 2023 Physical Chemistry Chemical Physics, 25 (23), pp.16048-16059. DOI: 10.1039/d2cp05363b.