Drugs to treat cancer and Alzheimer’s disease usually target the active sites of specific protein molecules sustaining the disease. Traditional drug design views proteins as rigid 3-D objects with active sites consisting of surface-accessible “pockets” with a specific, well-defined structure. Traditional drug design involves finding small molecules with shapes that fit specifically into this pocket. A new study from University of Notre Dame researchers suggests that there are alternative approaches to targeting these proteins, a significant finding for future clinical applications.
Mr. Mike Harper, benefactor of the Harper Cancer Research Institute (HCRI), died this weekend in Omaha NE at the age of 88.
Professors of chemistry and biochemistry, Paul Helquist and Olaf Wiest, together with Frederick Maxfield of Cornell University have received a U.S. patent for potential treatments for Niemann-Pick Type C (NPC) disease. Patent No. 9,333,222, “Histone deacetylase inhibitors as therapeutic agents for Niemann-Pick Type C Disease,” covers the full class of histone deacetylase inhibitors for the genetic, fatal lysosomal storage disorder and related diseases.
Over 70 researchers from a dozen universities in the Midwest gathered at Notre Dame for the 3rd Midwest Ovarian Cancer Coalition workshop to discuss the latest advances in ovarian cancer research.
Seven members of the Pontifical University of Chile (PUC) visited Notre Dame last week to strengthen developing research partnerships and plan upcoming workshops in biochemistry and chemistry, the latest in a partnership between the universities started in 2013.
Building on the partnership that the University of Notre Dame formed with the Ara Parseghian Medical Research Foundation in 2010, the University has now established the Ara Parseghian Medical Research Fund and is moving the administrative functions and granting process of the foundation from Tucson, Arizona, to Notre Dame.
Through this partnership, the Parseghian family will continue their fight to find a cure or treatment for Niemann-Pick Type C (NPC) disease and will continue to help fundraise and support researchers around the world.
A novel three-dimensional cell culture technique is making it possible for researchers to study tumors and evaluate potential cancer therapeutics quicker and more efficiently.
Three faculty members from the Department of Chemistry and Biochemistry have received awards for exemplary work in undergraduate teaching and advising. Xavier Creary, Charles L. Huisking Professor of Chemistry, and Amanda Hummon, Huisking Foundation Inc. Associate Professor of Chemistry and Biochemistry, have received 2016 Rev. Edmund P. Joyce, C.S.C. Awards for Excellence in Undergraduate Teaching. Dr. DeeAnne Goodenough-Lashua, has been selected to receive a Dockweiler Award for Excellence in Undergraduate Advising.
Twelve graduate students who are instructors and teaching assistants in the College of Science received the Outstanding Graduate Student Teaching Award from the Kaneb Center for Teaching and Learning. The recipients are Bide Xiong of Applied and Computational Mathematics and Statistics; Jenifer Gifford, Sheri Sanders, Kimbra Turner, and Victoria Zellmer of Biological Sciences; Michael Brennan, Clyde Daly, Ruth Nelson and Emily Shangle of Chemistry and Biochemistry; Edward Burkard and Brian Stoyell-Mulholland of Mathematics; and Bryce Frentz of Physics.
Haifeng Gao and Vlad Iluc, assistant professors of chemistry and biochemistry, have been selected to receive National Science Foundation (NSF) Faculty Early Career Development (CAREER) Program awards. These awards are the NSF’s most prestigious awards offered to junior faculty members and are given to recognize outstanding research, education, and integration of education and research. Prof. Gao and Prof. Iluc join the 14 other chemistry and biochemistry faculty members selected as CAREER award recipients.…
The National Science Foundation recently announced the winners of the 2016 Graduate Research Fellowship Program (GRFP), with 24 current Notre Dame students winning the prestigious award and another 17 earning honorable mention. Overall, there were 41 students recognized by the NSF. This doubles the number of Notre Dame awardees from 2015, and nearly doubles the previous Notre Dame record of 26, set last year, for total students recognized by the NSF.
Notre Dame International has awarded Global Collaboration Initiative funding to 18 projects submitted by faculty members engaged in reputation-advancing research with colleagues at universities around the world. The GCI awards support faculty-led international initiatives by providing seed funding for sustainable research collaborations.
We are happy to welcome Dr. Jessica Brown to the faculty at Notre Dame as an Assistant Professor of Chemistry & Biochemistry. Dr. Brown will establish her research group specializing in understanding the biological, biochemical, and structural roles of RNA triple helices. Her research interests are centered on RNA-protein biochemistry and structural biology, which can play important roles in cancer identification and treatment.
Dr. Mary Prorok, Assistant Chair of the Department of Chemistry and Biochemistry, has been selected to receive a 2016 Presidential Leadership Award. This award, conferred by the University of Notre Dame, is given to recognize staff supervisors who demonstrate outstanding servant leadership.
Notre Dame hosted 22 local middle school students in the first St. Joseph County You Be the Chemist (YBTC) Local Challenge, sponsored by Dow Chemical Company, in the Jordan Hall of Science on March 12. Chemistry graduate students Karen Bailey, Kasey Clear, and Emily Amenson organized the event in collaboration with the Chemistry Graduate Student Organization (CGSO) and Association for Women in Science, Notre Dame Chapter (AWIS-ND). Members of CGSO tutored students in grades fifth to eight at Edison Intermediate Center, Christ the King Catholic School, and Holy Family School for weeks and judged the event.
The Department of Chemistry and Biochemistry at the University of Notre Dame and Kyoto University’s Institute for Chemical Research will soon be exchanging faculty, staff, students and ideas, building on a partnership started by Notre Dame International. Chair of Department of Chemistry and Biochemistry, Ken Henderson says an official memorandum of understanding between his department and Kyoto’s institute lays out a template for collaboration. In addition to enabling student and faculty visits, the agreement lays the groundwork for growing research partnerships and the development of joint conferences and workshops. It is the type of interaction envisioned when Notre Dame International and Kyoto University initiated the institutional partnership level two years ago.
Through Notre Dame International, the University of Notre Dame and Heidelberg University have established a collaboration in which students from Germany have taken classes and conducted research at Notre Dame since August, part of an ongoing, broad collaboration with Heidelberg University that was established in 2104. Alex Dimmling and Lennart Schleper, who both finished their bachelor’s degrees at Heidelberg last June, are returning to Germany to pursue master’s degrees with credit from the Notre Dame experience.
Colorectal cancer, one of the most commonly diagnosed cancers in the United States, is not a commonly discussed disease. Often symptomless in early stages, the cancer is more difficult to treat as it progresses, requiring chemotherapy in later stages. Researchers at the University of Notre Dame are working on a way to identify patients who would benefit from chemotherapy before the cancer progresses.
Harper Cancer Research Institute Director Dr. Sharon Stack was on Capitol Hill joining members of the Ovarian Cancer Research Fund Alliance to advocate for the programs and research necessary for better ovarian cancer treatment. Advocates went to congressional offices and stated that prevention, awareness, development of new treatments and diagnostics, and better access to existing therapies are critical to battling this terrible disease.