News

New antibiotic holds promise against antibiotic-resistant infections

Author: Gene Stowe

Mayland Chang and Shahriar Mobashery

Estimates of deaths from methicillin-resistant Staphylococcus aureus (MRSA) in the United States range upwards of 19,000 annually. Around 1960, when Staphylococcus aureus developed resistance to first-generation penicillin, methicillin and other second-generation beta-lactam antibiotics were adopted to fight the illness. The modern variants of the bacterium have developed resistance to the four drugs now used to treat it.

A team of researchers led by Shahriar Mobashery and Mayland Chang at the University of Notre Dame has discovered a promising new antibiotic, a vital weapon against disease as pathogens evolve to develop resistance to long-used drugs.

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Steven Corcelli named chair of the GEAB

Author: Jayme Russell

Steven Corcelli

Steven Corcelli, professor of chemistry and biochemistry and director of graduate studies, has been appointed as chair of the Graduate Education Advisory Board (GEAB) in 2015. 

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Mayland Chang receives $1.6M American Diabetes Association research award

Author: Stephanie Healey

 

Mayland Chang

Diabetes affects more than 29 million Americans, or 9.3 percent of the population. One of the many complications of the disease is the inability of wounds to heal properly because diabetic patients often have nerve damage, weakened immune systems or narrow arteries. In 2010, 73,000 non-traumatic lower-limb amputations were performed in the United States due to diabetes.

The American Diabetes Association (ADA) announced Tuesday that it is funding a $1.6 million Accelerator Award to Mayland Chang, research professor of chemistry and biochemistry at the University of Notre Dame, to help lower that number. The research award, part of the association’s Pathway Awards program, will provide funding for Chang’s project, “A Strategy to Accelerate Diabetic Wound Repair,” over five years.

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Notre Dame, Saint Joseph Regional Medical Center join together to fight sepsis

Author: Arnie Phifer

 

Matthew Champion

Notre Dame and Saint Joseph Regional Medical Center, a member of the Trinity Health system, have announced that they are collaborating on research aimed at earlier detection of sepsis in patients. Sepsis, a potentially fatal illness in which the body has a severe inflammatory response to bacteria or other microorganisms, is the leading cause of death from infection in the world and is the costliest condition to U.S. hospitals.

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Renee Bouley earns Kirschstein National Research Service Award from NIH

Author: Stephanie Healey

Renee Bouley

Renee Bouley, a fourth-year graduate student in the Department of Chemistry and Biochemistry, has received a Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship from the National Institutes of Health (NIH). The fellowship will provide two years of funding for Bouley’s project, “Discovery of a new class of antibacterials that inhibits penicillin-binding proteins.”

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New Notre Dame-IUSM study examines important Ebola protein

Author: William G. Gilroy

Rob Stahelin

A new study by Robert Stahelin, an adjunct associate professor of chemistry and biochemistry at the University of Notre Dame and an associate professor at the Indiana University School of Medicine-South Bend, as well as a member of Notre Dame’s Eck Institute for Global Health, investigates how the most abundant protein that composes the Ebola virus, VP40, mediates replication of a new viral particle.

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Notre Dame sponsors first annual Soft Polymer Materials Symposium

Author: Provided by NDnano

 

Haifeng Gao

On November 4, Notre Dame hosted the inaugural Soft Polymer Materials Symposium at McKenna Hall. Twelve Notre Dame faculty and postdocs presented their current research in the areas of general synthesis, application, and characterization of soft polymer materials.

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Agrahari receives Fellowship from the Midwest Affliate of the American Heart Association

Author: Deborah Donahue

Garima Agrahari

Garima Agrahari, graduate student in the laboratory of Francis J. Castelllino, is a recent recipient of a two year predoctoral fellowship from the Midwest Affiliate of the American Heart Association.  The title of her study is “Molecular mechanisms of antiphagocytic activity mediated by Plasminogen binding group A streptococcal M-like protein.”

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Prashant Kamat named a Pravasi Fellow

Author: Stephanie Healey

Prashant Kamat

Prashant Kamat, the Rev. John A. Zahm, C.S.C. Professor of Science in the Department of Chemistry and Biochemistry and concurrent professor of chemical and biomolecular engineering, has been elected as a Prevasi Fellow by the Indian National Science Academy. Kamat was selected for his “most pioneering contributions to the world of science.” His fellowship will begin January 1, 2015.

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New study identifies potential targets for personalized cancer vaccines

Author: Stephanie Healey

New study identifies potential targets for personalized cancer vaccines

A team of University of Notre Dame scientists, in collaboration with researchers at the University of Connecticut, have announced the results of a new study on identifying potential targets for personalized cancer vaccines. The paper, “Genomic and bioinformatic profiling of mutational neoepitopes reveals new rules to predict anticancer immunogenicity,” was recently published in the Journal of Experimental Medicine. The research group at Notre Dame was led by Brian Baker, associate dean for research and graduate studies and professor of chemistry and biochemistry, and included Steven Corcelli, associate professor of chemistry and biochemistry, and graduate student Cory Ayers.

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Taylor named vice-chair for Gordon Research Conference on Natural Products

Author: Jayme Russell

Rich Taylor

Rich Taylor, associate vice president for research and professor of chemistry and biochemistry, presented a paper on his research, "Chemical and Biological Synthesis of Polyketide Natural Products", at the 2014 Gordon Research Conference on Natural Products at its annual July meeting. During this year’s conference, Taylor was elected Vice-Chair of the 2015 and Chair of the 2016 conferences to be held at Proctor Academy in Andover, N.H. This annual international meeting provides a forum for experts to share unpublished research results and engage in scientific discussions.

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Serianni appointed to U.S. Advisory Committee for International Carbohydrate Symposia

Author: Casey O'Donnell

Anthony Serianni

Anthony Serianni, professor of chemistry and biochemistry, was recently appointed to a five-year term on the U.S. Advisory Committee for International Carbohydrate Symposia by the CARB Division Executive Committee, a subgroup within the American Chemical Society. Serianni, an elected fellow of the American Chemical Society, will begin his term in early 2015.

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Chem Demo Team celebrates National Chemistry Week

Author: Casey O'Donnell

National Chemistry Week

In celebration of this year’s National Chemistry Week, Jordan Hall of Science turned into a veritable sweet shop of marshmallows, ice cream and M&Ms, all in the name of science. Chemistry has never sounded so sweet.

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Groundbreaking ceremony to celebrate $35 million gift from McCourtneys for research facility

Author: Dennis Brown

McCourtney Hall, west elevation

The University of Notre Dame will celebrate the generosity of alumnus Ted H. McCourtney and his wife, Tracy, in a groundbreaking ceremony Saturday (Oct. 4) for a world-class research facility to be named in their honor.

McCourtney Hall, to be located on the east side of the Notre Dame campus near Hesburgh Library, will be a 220,000-square-foot building underwritten by a $35 million gift from the McCourtneys.

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Peng named editor for Biophysical Journal

Author: Stephanie Healey

Jeffrey Peng

Jeffrey Peng, associate professor for chemistry and biochemistry and concurrent associate professor of physics was recently selected to serve a three-year term on the editorial board of Biophysical Journal beginning July 1, 2015.

 

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