Shahriar Mobashery
Navari Family Professor in Life Sciences
- Office
- 354B Mccourtney Hall
Notre Dame, IN 46556 - Phone
- +1 574-631-2933
- mobashery@nd.edu
Research Areas
- Biochemistry
- Organic Chemistry
Research Specialties
- Life Processes
- Medicine
- Synthesis
Prospective Graduate Students
Biography
| Year | Title |
|---|---|
| 2003-present | Navari Family Professor in Life Sciences, University of Notre Dame |
| 1997-2003 | Professor, Wayne State University |
| 1994-1997 | Associate Professor, Wayne State University |
| 1989-1994 | Assistant Professor, Wayne State University |
| 1986-1988 | Postdoctoral Research Associate, Rockefeller University |
| 1985 | Ph.D. in Chemistry, University of Chicago |
| 1981 | B.S. in Chemistry, University of Southern California |
| 1980 | B.S. in Biological Sciences, University of Southern California |
Selected Awards
2019 Emil Thomas Kaiser Award
2014-2016 Fellow, Science Without Borders, Brazil
2012 Research Achievement Award, University of Notre Dame
2007 Astellas USA Foundation Award of the American Chemical Society
2007 Fellow, America Association for the Advancement of Science
1999-2001 Charles H. Gershenson Distinguished Faculty Fellow
Research Interests
The Mobashery research program integrates computation, biochemistry, molecular biology, and the organic synthesis of medically important molecules. Bringing together these different disciplines is desirable to produce both scientific and medical advances for difficult, but critically important clinical problems.
Bacterial Antibiotic Resistance, Cell Wall and Discovery of Novel Antibiotics
The studies of antibiotics and antibiotic resistance are central themes in the Mobashery laboratory. Mechanisms of resistance to β-lactam antibiotics have been studied, with a focus on methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa as two nefarious human bacterial pathogens. A multidisciplinary approach is taken towards elucidating the distinct strategies that nature has devised to counter the use of antibiotics in the clinic. Significant work has also been directed towards the bacterial cell wall. The cell wall is a structure that encases the entire organism, and it is critically important for its survival. Its complex biosynthesis and recycling are subjects of study. Discovery of novel antibacterials is another large focus of attention.
Diseases of the Extracellular Matrix
The Mobashery laboratory is interested in diseases of the extracellular matrix (ECM). The ECM is an environment that surrounds every cell in higher organisms. There are many proteins and carbohydrates within this environment, whose homeostasis is highly regulated. When these regulatory processes break down, many disparate diseases ensue. The Mobashery lab investigates how these diseases develop and progress, and designs novel therapeutics for their intervention. The diseases of matrix of interest in the Mobashery lab include diabetes, pulmonary fibrosis, traumatic-brain injury and stroke.
Selected Publications
- Martinez-Caballero, S.; Freton, C.; Molina, R.; Bartual, S. G.; Gueguen-Chaignon, V.; Mercy, C.; Gago, F.; Mahasenan, K. V.; Munoz, I. G.; Lee, M.; Hesek, D.; Mobashery, S.; Hermoso, J. A. and Grangeasse, C. "Molecular Basis of the Final Step of Cell Division in Streptococcus pneumoniae" 2023 Cell Reports, 42, 112756. DOI: 10.1016/j.celrep.2023.112756.
- Janardhanan, J.; Kim, C.; Qian, Y.; Yang, J. Meisel, J. E.; Ding, D.; Speri, E.; Schroeder, V. A.; Wolter, W. R.; Oliver, A. G.; Mobashery, S. and Chang, M. Y. "A Dual-Action Antibiotic That Kills Clostridioides difficile Vegetative Cells and Inhibits Spore Germination" 2023 Proceedings of the National Academy of Sciences of the United States of America, 120 (20), e2304110120. DOI: 10.1073/pnas.2304110120.
- Avila-Cobian, L. F.; De Benedetti, S.; Kim, C.; Feltzer, R.; Champion, M. M.; Fisher, J. F. and Mobashery, S. "In Vitro Studies of the Protein-Interaction Network of Cell-Wall Lytic Transglycosylase RlpA of Pseudomonas Aeruginosa" 2022 Communications Biology, 5 (1), 1314. DOI: 10.1038/s42003-022-04230-x.
- Masitas, C.; Peng, Z. H.; Wang, M.; Konai, M. M.; Avila-Cobian, L. F.; Lemieux, L.; Hovanesian, J.; Grady, J. E.; Mobashery, S. and Chang, M. Y. "Matrix Metalloproteinase-14 as an Instigator of Fibrosis in Human Pterygium and its Pharmacological Intervention" 2022 ACS Pharmacology & Translational Science, 5 (8), pp.555-561. DOI: 10.1021/acsptsci.2c00125.
- Peng, Z. H.; Konai, M. M.; Avila-Cobian, L. F.; Wang, M.; Mobashery, S. and Chang, M. Y. "MMP-1 and ADAM10 as Targets for Therapeutic Intervention in Idiopathic Pulmonary Fibrosis" 2022 ACS Pharmacology & Translational Science, 5 (8), pp.548-554. DOI: 10.1021/acsptsci.2c00050.
- Peng, Z. H.; Nguyen, T. T.; Wang, M.; Anderson, B.; Konai, M. M.; Schroeder, V. A.; Wolter, W. R.; Page-Mayberry, T.; Peterson, C. E.; Mobashery, S. and Chang, M. "Proteomics Identification of Targets for Intervention in Pressure Ulcers" 2022 ACS Chemical Biology, 17 (6), pp.1357-1363. DOI: 10.1021/acschembio.2c00382.