Shahriar Mobashery

Shahriar Mobashery

Bioorganic Chemistry and Biochemistry

Biography

2003-present
Navari Family Professor in Life Sciences, University of Notre Dame
1997-2003
Professor, Wayne State University
1994-1997
Associate Professor, Wayne State University
1989-1994
Assistant Professor, Wayne State University
1986-1988
Postdoctoral Research Associate, Rockefeller University
1985
Ph.D. in Chemistry, University of Chicago
1981
B.S. in Chemistry, University of Southern California
1980
B.S. in Biological Sciences, University of Southern California

Selected Awards

2014-2016
Fellow, Science Without Borders, Brazil
2012
Research Achievement Award, University of Notre Dame
2007
Astellas USA Foundation Award of the American Chemical Society
2007
Elected Fellow, America Association for the Advancement of Science
1999-2001
Charles H. Gershenson Distinguished Faculty Fellow

Prof. Mobashery's Current CV

Research Interests

The Mobashery research program integrates computation, biochemistry, molecular biology, and the organic synthesis of medically important molecules. Bringing together these different disciplines is desirable to produce both scientific and medical advances for difficult, but critically important clinical problems.

Bacterial Antibiotic Resistance, Cell Wall and Discovery of Novel Antibiotics

The studies of antibiotics and antibiotic resistance are central themes in the Mobashery laboratory. Mechanisms of resistance to β-lactam antibiotics have been studied, with a focus on methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa as two nefarious human bacterial pathogens. A multidisciplinary approach is taken towards elucidating the distinct strategies that nature has devised to counter the use of antibiotics in the clinic. Significant work has also been directed towards the bacterial cell wall. The cell wall is a structure that encases the entire organism, and it is critically important for its survival. Its complex biosynthesis and recycling are subjects of study. Discovery of novel antibacterials is another large focus of attention. 

Diseases of the Extracellular Matrix

The Mobashery laboratory is interested in diseases of the extracellular matrix (ECM). The ECM is an environment that surrounds every cell in higher organisms. There are many proteins and carbohydrates within this environment, whose homeostasis is highly regulated. When these regulatory processes break down, many disparate diseases ensue. The Mobashery lab investigates how these diseases develop and progress, and designs novel therapeutics for their intervention. The diseases of matrix of interest in the Mobashery lab include diabetes, pulmonary fibrosis, traumatic-brain injury and stroke.

Recent Papers

  • Acebron, I.; Mahasenan, K.; De Benedetti, S.; Lee, M.; Artola-Recolons, C.; Hesek, D.; Wang, H.; Hermoso, J.; Mobashery, S. "Catalytic Cycle of the  N-Acetylglucosaminidase NagZ from Pseudomonas aeruginosa." J. Am. Chem. Soc. 2017, 139, 6795-6798.
  • Lee, M.; Hesek, D.; Dik, D.A.; Fishovitz, J.; Lastochkin, E.; Boggess, B.; Fisher, J.F.; Mobashery, S. "From Genome to Proteome to Elucidation of Reactions for All Eleven Known Lytic Transglycosylases from Pseudomonas aeruginosa." Angew. Chem. Int. Edit. 2017, 56, 2735-2739.
  • Mahasenan, K.V.; Molina, R.; Bouley, R.; Batuecas, M.T.; Fisher, J.F.; Hermoso, J.A.; Chang, M.; Mobashery, S. "Conformational Dynamics in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aereus, Allosteric Communication Network and Enablement of Catalysis" J. Am. Chem. Soc. 2017, 139, 2102-2110.
  • Dik, D.A.; Dominguez-Gil, T.; Lee, M.; Hesek, D.; Byun, B.; Fishovitz, J.; Boggess, B.; Hellman, L.M.; Fisher, J.F.; Hermoso, J.A.; Mobashery, S. "Muropeptide Binding and the X-Ray Structure of Effector Domain of the Transcriptional Regulator AmpR of Pseudomonas aeruginosa." J. Am. Chem. Soc. 2017, 137, 1448-1451.
  • Lee, M.; Dhar, S.; De Benedetti, S.; Hesek, D.; Boggess, B.; Blazquez, B.; Mathee, K.; Mobashery, S. "Muropeptides in Pseudomonas aeruginosa and their Role as Elicitors of β-Lactam-Antibiotic Resistance." Angew. Chem. Int. Edit. 2016, 55(24), 6882-6886.

Contact Information

  • Navari Family Professor in Life Sciences
  • Office: 354B McCourtney
  • Phone: 574-631-2933
  • Send an email

Primary Research Areas

Research Specialties