- George and Winifred Clark Chair Professor of Chemistry, University of Notre Dame
- Professor, University of Notre Dame
- Associate Professor, University of Notre Dame
- Assistant Professor, University of Notre Dame
- Postdoctoral Research Associate, University of California, Berkeley
- Ph.D. in Bioorganic Chemistry, Cornell University
- B.S. in Chemistry, North Dakota State University
- Outstanding Collaborator, Lilly Open Innovation Drug Discovery Program, Eli Lilly and Co.
- Henry L. Bolley Academic Achievement Award, North Dakota State University Alumni Award
- James S. Burns CSC award for Graduate Education, University of Notre Dame
- Elected Fellow, America Association for the Advancement of Science
The primary interests in Professor Miller's laboratory are in synthetic and bioorganic chemistry. Most effort is directed toward the development of new methodology and its incorporation into the syntheses and study of biologically important compounds. Special emphasis is given to asymmetrical syntheses and studies of hydroxamic acid containing microbial iron transport agents (siderophores), amino acids, peptides, b-lactam antibiotics and carbocyclic analogs of antifungal and anticancer nucleosides. The group has completed the first syntheses of the siderophores aerobactin, arthorobactin, schizokinen, several mycobactins, foroxymithine and several analogs. Recent efforts have been directed toward the syntheses and study of siderophore-antibiotic conjugates in a program designed to develop iron transport-mediated drug delivery agents, including those with potential microbe-triggered release processes.
Much effort has addressed the syntheses of functionalized b-lactams, the core unit of an important class of antibiotics. The result has been the development of an efficient, and generally applicable, synthetic approach based on a biomimetic N-C4 closure. This process and subsequent chemistry has facilitated the synthesis of several novel antibiotics and b-lactamase inhibitors. The chemical versatility of the methods indicates that a variety of new b-lactams may be synthesized for studying important structure-activity relationships.
Recent studies of acylnitroso cycloadditions by oxidation of hydroxamic acids have led to the development of new methods for the asymmetric syntheses of a variety of biologically interesting compounds.
New chemical and enzymatic methodologies for the asymmetrical syntheses of other biologically important molecules are also being developed.
- Moraski, G.C.; Oliver, A.G.; Markley, L.D.; Cho, S.; Franzblau, S.G.; Miller, M.J. "Scaffold-switching: An exploration of 5,6-fused bicyclic heteroaromatics systems to afford antituberculosis activity akin to the imidazo[1,2-a]pyridine-3-carboxylates." Bioorg. Med. Chem. Lett. 2014, 24 (15), 3493-3498.
- Tiwari, R.; Mollmann, U.; Cho, S.; Franzblau, S.G.; Miller, P.A.; Miller, M.J. "Design and Syntheses of Anti-tuberculosis Agents Inspired by BTZ043 Using a Scaffold Simplification Strategy." ACS Med. Chem. Lett. 2014, 5 (5), 587-591.
- Jobbins, M.O.; Miller, M.J. "Syntheses of Hydroxamic Acid-Containing Bicyclic beta-Lactams via Palladium-Catalyzed Oxidative Amidation of Alkenes." J. Org. Chem. 2014, 79 (4), 1620-1625.
- Cheng, Y.; Moraski, G.C.; Cramer, J.; Miller, M.J.; Schorey, J.S. "Bactericidal Activity of an Imidazo[1,2-a]pyridine Using a Mouse M. tuberculosis Infection Model." PLOS One 2014, 9 (1), e87483.
- Carosso, S.; Miller, M.J. "Nitroso Diels-Alder (NDA) reaction as an efficient tool for the functionalization of diene-containing natural products." Org. Biomol. Chem. 2014, 12 (38), 7445-7468.
- Wencewicz, T.A.; Miller, M.J. "Biscatecholate-Monohydroxamate Mixed Ligand Siderophore-Carbacephalosporing Conjugates are Selective Sideromycin Antibiotics that Target Acinetobacter baumannii." J. Med. Chem. 2013, 56 (10), 4044-4052.