Marvin J. Miller

Marvin J. Miller

Synthetic Organic, Bioorganic, and Medicinal Chemistry

Biography

1996-present
George and Winifred Clark Chair Professor of Chemistry, University of Notre Dame
1986-1996
Professor, University of Notre Dame
1982-1986
Associate Professor, University of Notre Dame
1977-1982
Assistant Professor, University of Notre Dame
1975-1977
Postdoctoral Research Associate, University of California, Berkeley
1976
Ph.D. in Bioorganic Chemistry, Cornell University
1971
B.S. in Chemistry, North Dakota State University

Selected Awards

2012
Outstanding Collaborator, Lilly Open Innovation Drug Discovery Program, Eli Lilly and Co.
2012
Henry L. Bolley Academic Achievement Award, North Dakota State University Alumni Award
2011
James S. Burns CSC award for Graduate Education, University of Notre Dame
2010
Elected Fellow, America Association for the Advancement of Science

Research Interests

The primary interests in Professor Miller's laboratory are in synthetic and bioorganic chemistry. Most effort is directed toward the development of new methodology and its incorporation into the syntheses and study of biologically important compounds. Special emphasis is given to asymmetrical syntheses and studies of hydroxamic acid containing microbial iron transport agents (siderophores), amino acids, peptides, b-lactam antibiotics and carbocyclic analogs of antifungal and anticancer nucleosides. The group has completed the first syntheses of the siderophores aerobactin, arthorobactin, schizokinen, several mycobactins, foroxymithine and several analogs. Recent efforts have been directed toward the syntheses and study of siderophore-antibiotic conjugates in a program designed to develop iron transport-mediated drug delivery agents, including those with potential microbe-triggered release processes.

Much effort has addressed the syntheses of functionalized b-lactams, the core unit of an important class of antibiotics. The result has been the development of an efficient, and generally applicable, synthetic approach based on a biomimetic N-C4 closure. This process and subsequent chemistry has facilitated the synthesis of several novel antibiotics and b-lactamase inhibitors. The chemical versatility of the methods indicates that a variety of new b-lactams may be synthesized for studying important structure-activity relationships.

Recent studies of acylnitroso cycloadditions by oxidation of hydroxamic acids have led to the development of new methods for the asymmetric syntheses of a variety of biologically interesting compounds.

New chemical and enzymatic methodologies for the asymmetrical syntheses of other biologically important molecules are also being developed.

Recent Papers

  • “Resins with Identical Specifications are not Identical. Identifying a Useful Solid-Phase Resin,” Isabelle Bouillon, Miroslav Soural, Marvin J. Miller and Viktor Krchňák, J. Combinatorial Chemistry, 2009, 11, 213-215.
  • “Pd(0)/InI-Mediated Allylic Additions to 4-Acetoxy-2-Azetidinone: New Route to Highly Functionalized Carbocyclic Scaffolds,” Cara Cesario and Marvin J. Miller, Org. Lett. 2009, 11, 1293-1295.
  • “Utilization of microbial iron assimilation processes for the development of new antibiotics and inspiration for the design of new anticancer agents,” Marvin J. Miller, Helen Zhu, Yanping Xu, Chunrui Wu, Andrew J. Walz, Anne Vergne, Garrett Moraski, Albert A. Minnick, Julia McKee-Dolence, E. Kurt Dolence, Jingdan Hu, Kelley Fennell, Scott Franzblau, Francois Malouin and Ute Möllmann Biometals, 2009, 22, 61-75.
  • “Syntheses and Biological Activity Studies of Novel Sterol Analogs from Nitroso Diels-Alder Reactions of Ergosterol,” Baiyuan Yang, Patricia A. Miller, Ute Möllmann, and Marvin J. Miller Org. Lett. 2009, 11, 2828-2831..
  • “Is drug release necessary for antimicrobial activity of siderophore-drug conjugates? Syntheses and biological studies of the naturally occurring salmycin “Trojan Horse” antibiotics and synthetic desferridanoxamine-antibiotic conjugates,” Timothy A. Wencewicz, Ute Möllmann, Timothy E. Long and Marvin J. Miller Biometals, 2009, 22, 633-648.
  • “Synthesis and Anti-Cancer Activity of New Hydroxamic Acid Containing 1,4-Benzodiazepines,” Larry P. Tardibono and Marvin J. Miller, Org. Lett. 2009, 11, 575-1578.

Contact Information

  • George and Winifred Clark Professor of Chemistry and Biochemistry
  • Office: 346 Nieuwland Science Hall
  • Phone: 574-631-7571
  • Send an email
  • Visit Website

Primary Research Areas

Research Specialties