- Campbell Family Assistant Professor of Cancer Research, University of Notre Dame
- Associate Specialist, University of California, San Francisco
- Postdoctoral Fellow, University of California, San Francisco
- Ph.D. in Cell and Developmental Biology, Harvard University
- B.S. in Biochemistry, B.S. in Molecular Biology, University of Texas, Austin
- American Cancer Society Postdoctoral Fellowship
- Ruth L. Kirschstein National Research Service Award, NIH
- NSF Predoctoral Fellowship
Littlepage's research program is focused on the contributions of the epithelium and surrounding stroma/microenvironment to both cancer progression and normal tissue development in the mammary gland and prostate.
She has focused on three major projects:
- The transcription factor/oncogene Znf217 that promotes a progenitor cell phenotype, metastasis and chemoresistance during breast cancer progression
- MMP3/Stromelysin-1 promotion of progenitor expansion, genomic instability, DNA damage, and centrosome amplification during mammary tumor progression
- Matrix metalloproteinases that contribute distinct roles in neuroendocrine prostate carcinogenesis, metastasis, and angiogenesis progression.
Overall, her research is grounded in understanding the mechanisms of cancer progression and in identifying therapies that prevent or reverse cancer in patients. She develops and uses integrated mouse models and genome-wide association studies to understand the contributions of specific genes in vivo at multiple points in cancer progression, spanning from normal mammary development to tumor progression and metastasis and chemotherapy resistance.
She uses a combination of mouse and human xenograft in vivo models, cell culture and organotypic cultures, and systems biology approaches to study biomarkers of epithelial plasticity and to determine how these genes drive aberrations in fundamental biological processes, e.g., differentiation state, progenitor cell maintenance, metabolism, and genomic integrity.
She also is identifying targeted therapies appropriate for personalized treatment of cancer patients based on these biomarkers.
Littlepage, L.E., Adler, A.S., Kouros-Mehr, H., Huang, G., Chou, J., Krig, S.R., Griffith, O.L., Korkola, J.E., Qu, K., Lawson, D.A., Xue, Q., Sternlicht, M.D., Dijkgraaf, G.J., Yaswen, P., Rugo, H.S., Sweeney, C.A., Collins, C.C., Gray, J.W., Chang, H.Y., Werb, Z. "The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression." Cancer Discov. 2012 Jul;2(7):638-51. Epub 2012 May 10. Link
Littlepage, L.E., Sternlicht, M.D., Rougier, N., Phillips, J., Gallo, E., Yu, Y., Williams, K., Brenot, A., Gordon, J., Werb, Z. "Matrix metalloproteinases contribute distinct roles in neuroendocrine prostate carcinogenesis, metastasis, and angiogenesis progression." Cancer Res. 2010 Mar 15; 70(6):2224-34. Epub 2010 Mar 9. Link
Kouros-Mehr, H., Bechis, S.K., Slorach, E.M., Littlepage, L.E., Egeblad, M., Ewald, A.J., Pai, S.Y., Ho, I.C., Werb, Z. "GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model." Cancer Cell. 2008 Feb; 13(2):141-52. Link
Adler, A.S., Littlepage, L.E., Lin, M., Kawahara, T.L.A., Wong, D.J., Liu, H., Werb, Z., Chang , H.Y. "CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression." Cancer Res. 2008 Jan 15; 68(2):506-15. Link
Egeblad, M., Littlepage, L.E., Werb, Z. "The fibroblastic coconspirator in cancer progression." Cold Spring Harb Symp Quant Biol. 2005; 70:383-8. Review. Link
Radisky, D.C., Levy, D.D., Littlepage, L.E., Liu, H., Nelson, C.M., Fata, J.E., Leake, D., Godden, E.L., Albertson, D.G., Nieto, M.A., Werb, Z., Bissell, M.J. "Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability." Nature 2005 Jul 7; 436(7047):123-7. Link