- Campbell Family Assistant Professor of Cancer Research, University of Notre Dame
- Associate Specialist, University of California, San Francisco
- Postdoctoral Fellow, University of California, San Francisco
- Ph.D. in Cell and Developmental Biology, Harvard University
- B.S. in Biochemistry, B.S. in Molecular Biology, University of Texas, Austin
- CTSI Young Investigator Award
- American Cancer Society Postdoctoral Fellowship
- Ruth L. Kirschstein National Research Service Award, NIH
- NSF Predoctoral Fellowship
Littlepage's research program is focused on the contributions of the epithelium and surrounding stroma/microenvironment to both cancer progression and normal tissue development in the mammary gland and prostate.
She has focused on three major projects:
- The transcription factor/oncogene Znf217 that promotes a progenitor cell phenotype, metastasis and chemoresistance during breast cancer progression
- MMP3/Stromelysin-1 promotion of progenitor expansion, genomic instability, DNA damage, and centrosome amplification during mammary tumor progression
- Matrix metalloproteinases that contribute distinct roles in neuroendocrine prostate carcinogenesis, metastasis, and angiogenesis progression.
Overall, her research is grounded in understanding the mechanisms of cancer progression and in identifying therapies that prevent or reverse cancer in patients. She develops and uses integrated mouse models and genome-wide association studies to understand the contributions of specific genes in vivo at multiple points in cancer progression, spanning from normal mammary development to tumor progression and metastasis and chemotherapy resistance.
She uses a combination of mouse and human xenograft in vivo models, cell culture and organotypic cultures, and systems biology approaches to study biomarkers of epithelial plasticity and to determine how these genes drive aberrations in fundamental biological processes, e.g., differentiation state, progenitor cell maintenance, metabolism, and genomic integrity.
She also is identifying targeted therapies appropriate for personalized treatment of cancer patients based on these biomarkers.
- Sawe, R. T.; Mining, S. K.; Ofulla, A. V.; Patel, K.; Guyah, B.; Chumba, D.; Prosperi, J. R.; Kerper, M.; Shi, Z.; Sandoval-Cooper, M.; Taylor, K.; Badve, S.; Stack, M. S.; Littlepage, L. E. "Tumor infiltrating leukocyte density is independent of tumor grade and molecular subtype in aggressive breast cancer of Western Kenya." Trop. Med. Health 2017, 45, 19.
- Richards, K. E.; Zeleniak, A. E.; Fishel, M. L.; Wu, J.; Littlepage, L. E.; Hill, R. "Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells." Oncogene 2017, 36, 1770-1778.
- Coughlin, T. R.; Romero-Moreno, R.; Mason, D. E.; Nystrom, L.; Boerckel, J. D.; Niebur, G. L.; Littlepage, L. E. "Bone: A Fertile Soil for Cancer Metastasis." Curr. Drug Targets 2017, 18, 1281-1295.
- Hartland, E.; Jang, C.; Moreno, R. R.; McGarel, M.; Badve, S.; Littlepage, L. "Unexpected roles for stromal MMP3 during breast cancer." Cancer Res. 2016, 76.
- Sawe, R. T.; Kerper, M.; Badve, S.; Li, J.; Sandoval-Cooper, M.; Xie, J.; Shi, Z.; Patel, K.; Chumba, D.; Ofulla, A.; Prosperi, J.; Taylor, K.; Stack, M. S.; Mining, S.; Littlepage, L. E. "Aggressive breast cancer in western Kenya has early onset, high proliferation, and immune cell infiltration." BMC Cancer 2016, 16, 204.
- Suarez, C. D.; Littlepage, L. E. "Patient-Derived Tumor Xenograft Models of Breast Cancer." Breast Cancer: Methods and Protocols 2016, 1406, 211-223.