Holly Goodson

Holly Goodson

Molecular and Cell Biology and Biophysics

Biography

2014-present
Professor, University of Notre Dame
2006-2014
Associate Professor, University of Notre Dame
2000-2006
Assistant Professor, University of Notre Dame
1995-1999
Postdoctoral Fellow, University of Geneva, Switzerland
1996
Ph.D. in Biochemistry, Stanford University
1988
A.B. in Molecular Biology, Princeton University

Selected Awards

2012
Thomas P. Madden Award for Exceptional Teaching of First Year Students
2012
Joyce Award for Excellence in Undergraduate Teaching
2008-2010
Elected member, American Society for Cell Biology National Council
1996-1999
Helen Hay Whitney Foundation Postdoctoral Fellowship
1995-1996
EMBO Postdoctoral Fellowship
1988-1993
National Science Foundation Predoctoral Fellowship

Research Interests

The Goodson laboratory uses multifaceted approaches including biochemistry, molecular biology, and computational biology to address cell biological questions. We focus on the microtubule cytoskeleton – the dynamic network of protein fibers that pulls the chromosomes apart at mitosis, acts as "railroad tracks" for intracellular transport, and organizes the cytoplasm. Questions that interest us include: how does this network assemble? What governs its dynamic turnover? How do other parts of the cell (organelles, chromosomes, the cell cortex) interact with microtubules? To answer these questions we use a combination of biochemistry, molecular biology, quantitative microscopy, and (in collaboration with applied mathematician Mark Alber) computational models of microtubule dynamics.   Topics of particular interest include microtubule plus-end tracking proteins (+TIPs), a network of diverse proteins that dynamically track growing microtubule plus ends, as well as the disease-associated proteins Tau (Alzheimer's) and stathmin (cancer).

A second long-term interest in the Goodson laboratory is molecular evolution. While establishing the history of protein families is an important goal in itself, our primary interest has been in using the history of a protein family to help understand how its members work now. We use nature’s mutagenesis (the set of related sequences present in the genome databases) and combine it with bioinformatics techniques such as homology modeling to perform structure/function analysis.  Recently we have taken advantage of unique continuous culture systems developed for a biosensor project to begin a new project studying the process of evolution in vitro and in silico.

Recent Papers

  • Gupta, K. K., Li, C., Duan, A. R., Alber, M. S., Goodson, H. V. (2013), ‘A mechanism for the catastrophe-promoting activity of the microtubule destabilizer Op18/stathmin,’ Proc Natl Acad Sci U S A, 110(51):20449-54.
     
  • Margolin, G, et al. (2012), ‘The mechanisms of microtubule catastrophe and rescue: implications from analysis of a dimer-scale computational model.’, Mol Biol Cell, 23 (4), 642-56.
     
  • Duan, A. R., Goodson, H. V. (2012), ‘Taxol-stabilized microtubules promote the formation of filaments from unmodified full-length Tau in vitro.’ Mol Biol Cell, 23: (24), 4796-4806.
     
  • Gupta, K. K., Joyce, M. V., Slabbekoorn, A. R., Zhu, Z. C., Paulson, B. A., Boggess, B., Goodson, H. V. (2010), ‘Probing interactions between CLIP-170, EB1, and microtubules.’ J Mol Biol, 395: (5), 1049-1062.
     
  • Gregoretti, I. V., Y. M. Lee, and H. V. Goodson (2004), ‘Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis’, J Mol Biol, 338 (1), 17-31

Contact Information

  • Professor
  • Office: 439 Stepan Chemistry
  • Phone: 574-631-7744
  • Send an email

Primary Research Areas

Research Specialties