Bradley Smith
Emil T. Hofman Professor of Science; Director, Notre Dame Integrated Imaging Facility
- Office
- 340J Mccourtney Hall
Notre Dame, IN 46556 - Phone
- +1 574-631-8632
- bsmith3@nd.edu
Research Areas
- Biochemistry
- Organic Chemistry
Research Specialties
- Life Processes
- Medicine
- Synthesis
Prospective Graduate Students
Biography
| Year | Title |
|---|---|
| 2008-present | Emil T. Hofman Professor of Science, University of Notre Dame |
| 2008-present | Director, Notre Dame Integrated Imaging Facility |
| 2001-2008 | Professor, University of Notre Dame |
| 1997-2001 | Associate Professor, University of Notre Dame |
| 1991-1997 | Assistant Professor, University of Notre Dame |
| 1990-1991 | Postdoctoral Fellow, Columbia University |
| 1989-1990 | Postdoctoral Fellow, Oxford University, UK |
| 1988 | Ph.D. in Chemistry, Pennsylvania State University |
| 1983 | B.Sc. in Chemistry, University of Melbourne, Australia |
Selected Awards
2018 Harold Kohn Endowed Distinguished Alumni Lecturer, The Pennsylvania State University
2012 Fellow, Royal Society of Chemistry
2011 Fellow, American Association for the Advancement of Science
2008 Visiting Fellow, Japan Society for Promotion of Science
2000 Kaneb Outstanding Undergraduate Teaching Award
Research Interests
SMART MOLECULES FOR IMAGING, TARGETING, AND HEALTH (SMITH). The specific research projects are diverse and encompass topics such as organic synthesis, membrane biophysics, photonics, and small animal imaging. A major aim is to develop novel molecular imaging probes that can detect dying cells in culture, and tumors and bacterial infection in living animals. Some of the fluorescent imaging probes are commercially available. They help accelerate the pre-clinical stages of drug discovery and development, and also enable new strategies for studying the biology of human disease. The probes may eventually be employed in humans for fluorescence guided surgery. A notable discovery is a family of interlocked molecules called squaraine-rotaxanes which have many potential applications as extremely bright and stable fluorescent Near-IR dyes. An offshoot of this work is the development of new methods of achieving laser-induced photothermolysis for biomedical imaging and therapeutic applications.
Selected Publications
- Gamage, R. S.; Chasteen, J. L. and Smith, B. D. "Lipophilic Anchors that Embed Bioconjugates in Bilayer Membranes: A Review" 2023 Bioconjugate Chemistry, 34 (6), pp.961-971. DOI: 10.1021/acs.bioconjchem.3c00204.
- Kommidi, S. and Smith, B. D. "Supramolecular Complexation of Azobenzene Dyes by Cucurbit[7]Uril" 2023 Journal of Organic Chemistry, 88 (13), pp.8431-8440. DOI: 10.1021/acs.joc.3c00423.
- Li, D. H.; Gamage, R. S.; Oliver, A. G.; Patel, N. L.; Usama, S. M.; Kalen, J. D.; Schnermann, M. J. and Smith, B. D. "Doubly Strapped Zwitterionic NIR-I and NIR-II Heptamethine Cyanine Dyes for Bioconjugation and Fluorescence Imaging" 2023 Angewandte Chemie-International Edition, 62, e202305062. DOI: 10.1002/anie.202305062.
- Chasteen, J. L.; Padilla-Coley, S.; Li, D. H. and Smith, B. D. "Palladium Responsive Liposomes for Triggered Release of Aqueous Contents" 2023 Bioorganic & Medicinal Chemistry Letters, 84, 129215. DOI: 10.1016/j.bmcl.2023.129215.
- Gamage, R. S. and Smith, B. D. "Spontaneous Transfer of Indocyanine Green from Liposomes to Albumin is Inhibited by the Antioxidant α-Tocopherol" 2022 Langmuir, 38 (39), pp.11950-11961. DOI: 10.1021/acs.langmuir.2c01715.
- Kommidi, S. and Smith, B. D. "Cucurbit[7]Uril Complexation of Near-Infrared Fluorescent Azobenzene-Cyanine Conjugates" 2022 Molecules, 27 (17), 5440. DOI: 10.3390/molecules27175440.