Wenhui Zhang received his B.S. and M.S. in analytical chemistry from the University of Science and Technology, Beijing, and his Ph.D. in biochemistry from the University of Notre Dame in 2009. He was a post-doctoral fellow at Notre Dame from 2009-2013 and a research scientist at Omicron Biochemicals, Inc. from 2013-2014. In 2014, he joined the faculty at Notre Dame as a research assistant professor.
Carbohydrates play key roles in many biological processes, including common and rare diseases such as diabetes, cancer, DCMs (disorders of carbohydrate metabolism), and CDGs (congenital disorders of glycosylation). Many biological processes, such as protein folding, cell signaling, fertilization, embryogenesis, immune response, cell cryobiology, and cell proliferation are mediated by carbohydrates. Although the field of glycoscience has burgeoned over the last several decades, the limited availability of affordable and accessible tools and technologies hinders research on elucidating and manipulating the functions of carbohydrates in many metabolic and disease processes.
Dr. Zhang's research focuses on: (1) chemical and chemoenzymatic synthesis of N-glycans, O-glycans, and other natural carbohydrate products such as sugar phosphates and ribonucleosides, (2) use of stable isotopically labeled compounds to examine structure, conformation, and reactivity of carbohydrates in solution using modern multidimensional NMR methods and computational techniques (DFT and MD), (3) carbohydrate degradation and reaction mechanism studies by NMR and mass spectrometry using stable isotopically labeled compounds, and (4) simplifying current synthetic methods and developing new, cost-effective routes to prepare core labeled carbohydrates to render stable isotopically labeled carbohydrates more accessible and affordable to investigators.
- Zhang, W., Turney, T., Meredith, R., Pan, Q., Sernau, L., Wang, X., Hu, X., Woods, R.J., Carmichael, I., Serianni, A.S. "Conformational Populations of β-(1→4) O-Glycosidic Linkages Using Redundant NMR J-Couplings and Circular Statistics" 2017 Journal of Physical Chemistry B, 121 (14), pp. 3042-3058. DOI: 10.1021/acs.jpcb.7b02252
- Bose-Basu, B., Zhang, W., Kennedy, J.L.W., Hadad, M.J., Carmichael, I., Serianni, A.S. "13C-Labeled Idohexopyranosyl Rings: Effects of Methyl Glycosidation and C6 Oxidation on Ring Conformational Equilibria" 2017 Journal of Organic Chemistry, 82 (3), pp. 1356-1370. DOI: 10.1021/acs.joc.6b02399
- Zhang, W., Turney, T., Surjancev, I., Serianni, A.S. "Enzymatic synthesis of ribo- and 2′-deoxyribonucleosides from glycofuranosyl phosphates: An approach to facilitate isotopic labeling" 2017 Carbohydrate Research, 449, pp. 125-133. DOI: 10.1016/j.carres.2017.07.006
- Turney, T., Pan, Q., Sernau, L., Carmichael, I., Zhang, W., Wang, X., Woods, R.J., Serianni, A.S. "O-acetyl side-chains in monosaccharides: Redundant NMR spin- couplings and statistical models for acetate ester conformational analysis" 2017 Journal of Physical Chemistry B, 121 (1), pp. 66-77. DOI: 10.1021/acs.jpcb.6b10028
- Hadad, M.J., Zhang, W., Turney, T., Sernau, L., Wang, X., Woods, R.J., Incandela, A., Surjancev, I., Wang, A., Yoon, M.-K., Coscia, A., Euell, C., Meredith, R., Carmichael, I., Serianni, A.S. "NMR Spin-Couplings in Saccharides: Relationships between Structure, Conformation and the Magnitudes of J HH, J CH and J CC Values" 2017 New Developments in NMR, 2017-January (10), pp. 20-100. DOI: 10.1039/9781782623946-00020
- Zhang, W., Pan, Q., Serianni, A.S. "A chemical synthesis of a multiply 13C-labeled hexasaccharide: a high-mannose N-glycan fragment" 2016 Journal of Labelled Compounds and Radiopharmaceuticals, 59 (14), pp. 673-679. DOI: 10.1002/jlcr.3418