Per-Ola Norrby

Per-Ola Norrby

Adjunct Professor


Principal Scientist, AstraZeneca
Professor, University of Gothenburg
Associate Professor, Technical University of Denmark
Associate Professor, Royal Danish School of Pharmacy, Copenhagen, Denmark
Research Associate, Royal Danish School of Pharmacy, Copenhagen, Denmark
Postdoctoral Researcher, Scripps Research Institute

Selected Awards

Eli Lilly Lecturer, University of Notre Dame
Syntheses, Inc. Lecturer, University of Notre Dame
Bengt Lundqvist Memory Award
Ernst Jonsson Graduate Fellowship

Research Interests

My main research interest is broad understanding of chemical reactivity from both an experimental and theoretical viewpoint. With collaborators at Notre Dame, primarily Paul Helquist and Olaf Wiest, I work on understanding and predicting selectivity in catalytic reactions. In my work at AstraZeneca, I focus on understanding and predicting ex-vivo degradation of drugs.

Recent Papers

  • Biosca, M., Salto, J., Magre, M., Norrby, P. -O., Pamies, O., Dieguez, M. "An improved class of phosphite-oxazoline ligands for Pd-catalyzed allylic substitution reactions" 2019 ACS Catalysis, 9 (7), pp. 6033-6048. DOI:10.1021/acscatal.9b01166.
  • Norrby, P. -O. "Holistic models of reaction selectivity" 2019 Nature, 571 (7765), pp. 332-333. DOI:10.1038/d41586-019-02148-9.
  • Ludvigsson, J.W., Wikström, H., Andersson, T., Norrby, P.-O. "Degradation caused by incompatibility between sodium stearyl fumarate (PRUV) and AZD7986 in the drug product" 2018 Journal of Pharmaceutical and Biomedical Analysis, 158, pp. 82-87. DOI: 10.1016/j.jpba.2018.05.036
  • Biosca, M., Jackson, M., Magre, M., Pàmies, O., Norrby, P.-O., Diéguez, M., Guiry, P.J. "Enantioselective Synthesis of Sterically Hindered Tertiary α-Aryl Oxindoles via Palladium-Catalyzed Decarboxylative Protonation. An Experimental and Theoretical Mechanistic Investigation" 2018 Advanced Synthesis and Catalysis, 360 (16), pp. 3124-3137. DOI: 10.1002/adsc.201800507
  • De Scheerder, L., Sparén, A., Nilsson, G.A., Norrby, P.-O., Örnskov, E. "Designing flexible low-viscous sieving media for capillary electrophoresis analysis of ribonucleic acids" 2018 Journal of Chromatography A, 1562, pp. 108-114. DOI: 10.1016/j.chroma.2018.05.048
  • Engkvist, O., Norrby, P.-O., Selmi, N., Lam, Y.-H., Peng, Z., Sherer, E.C., Amberg, W., Erhard, T., Smyth, L.A. "Computational prediction of chemical reactions: current status and outlook" 2018 Drug Discovery Today, 23 (6), pp. 1203-1218. DOI: 10.1016/j.drudis.2018.02.014

Contact Information

Primary Research Areas

Research Specialties