Per-Ola Norrby

Per-Ola Norrby

Adjunct Professor

Biography

2014-present
Principal Scientist, AstraZeneca
2006-2014
Professor, University of Gothenburg
2000-2006
Associate Professor, Technical University of Denmark
1997-2000
Associate Professor, Royal Danish School of Pharmacy, Copenhagen, Denmark
1994-1996
Research Associate, Royal Danish School of Pharmacy, Copenhagen, Denmark
1992-1993
Postdoctoral Researcher, Scripps Research Institute

Selected Awards

2004
Eli Lilly Lecturer, University of Notre Dame
2000
Syntheses, Inc. Lecturer, University of Notre Dame
1992
Bengt Lundqvist Memory Award
1985-1989
Ernst Jonsson Graduate Fellowship

Research Interests

My main research interest is broad understanding of chemical reactivity from both an experimental and theoretical viewpoint. With collaborators at Notre Dame, primarily Paul Helquist and Olaf Wiest, I work on understanding and predicting selectivity in catalytic reactions. In my work at AstraZeneca, I focus on understanding and predicting ex-vivo degradation of drugs.

Recent Papers

  • Biosca, M., Salto, J., Magre, M., Norrby, P. -O., Pamies, O., Dieguez, M. "An improved class of phosphite-oxazoline ligands for Pd-catalyzed allylic substitution reactions" 2019 ACS Catalysis, 9 (7), pp. 6033-6048. DOI:10.1021/acscatal.9b01166.
  • Norrby, P. -O. "Holistic models of reaction selectivity" 2019 Nature, 571 (7765), pp. 332-333. DOI:10.1038/d41586-019-02148-9.
  • Ludvigsson, J.W., Wikström, H., Andersson, T., Norrby, P.-O. "Degradation caused by incompatibility between sodium stearyl fumarate (PRUV) and AZD7986 in the drug product" 2018 Journal of Pharmaceutical and Biomedical Analysis, 158, pp. 82-87. DOI: 10.1016/j.jpba.2018.05.036
  • Biosca, M., Jackson, M., Magre, M., Pàmies, O., Norrby, P.-O., Diéguez, M., Guiry, P.J. "Enantioselective Synthesis of Sterically Hindered Tertiary α-Aryl Oxindoles via Palladium-Catalyzed Decarboxylative Protonation. An Experimental and Theoretical Mechanistic Investigation" 2018 Advanced Synthesis and Catalysis, 360 (16), pp. 3124-3137. DOI: 10.1002/adsc.201800507
  • De Scheerder, L., Sparén, A., Nilsson, G.A., Norrby, P.-O., Örnskov, E. "Designing flexible low-viscous sieving media for capillary electrophoresis analysis of ribonucleic acids" 2018 Journal of Chromatography A, 1562, pp. 108-114. DOI: 10.1016/j.chroma.2018.05.048
  • Engkvist, O., Norrby, P.-O., Selmi, N., Lam, Y.-H., Peng, Z., Sherer, E.C., Amberg, W., Erhard, T., Smyth, L.A. "Computational prediction of chemical reactions: current status and outlook" 2018 Drug Discovery Today, 23 (6), pp. 1203-1218. DOI: 10.1016/j.drudis.2018.02.014

Contact Information

Primary Research Areas

Research Specialties