Lance Hellman

Lance Hellman


Research Assistant Professor, University of Notre Dame
Adjunct Assistant Professor, Indiana University South Bend
Research Scientist, University of Notre Dame
Postdoctoral Scholar, University of Notre Dame
Ph.D. in Biochemistry, University of Kentucky
Cytotechnologist, Gettysburg Hospital, Gettysburg, PA
Cytotechnologist, Holy Spirit Hospital, Camp Hill, PA
B.S. in Cytotechnology, Medical University of South Carolina
B.S. in Biology, University of South Carolina

Research Interests

My research focuses on understanding the interaction between T-cell receptors and the specific antigenic peptides they recognize. My particular interest is in trying to redistribute the binding energies within the interface, between the T-cell receptor and the antigen, to reduce cross reactivity of the receptor towards other antigens.

Recent Papers

  • Spear, T. T.; Wang, Y.; Foley, K. C.; Murray, D. C.; Scurti, G. M.; Simms, P. E.; Garrett-Mayer, E.; Hellman, L. M.; Baker, B. M.; Nishimura, M. I. "Critical Biological Parameters Can Modulate Affinity as a Determinant of Function in T Cell Receptor Gene-Modified T Cells." Cancer Immunol. Immunother. 2017, 66(11), 1411-1424.
  • Wang, Y.; Singh, N. K.; Spear, T. T.; Hellman, L. M.; Piepenbrink, K. H.; Vander Kooi, C. W.; Rosen, H. R.; Nishimura, M. I.; Baker, B. M. "How an Alloreactive T Cell Receptor Achieves Peptide and MHC Specificity: Implications for Alloreactivity and Immunotherapy." Proc. Nat. Acad. Sci. USA 2017, 114(24), E4792-E4801.
  • Dik, D. A.; Dominguez-Gil, T.; Lee, M.; Hesek, D.; Byun, B.; Fishovitz, J.; Boggess, B.; Hellman, L. M.; Fisher, J. F.; Hermoso, J. A.; Mobashery, S. "Muropeptide Binding and the X-ray Structure of the Effector Domain of the Transcriptional Regulator AmpR of Pseudomonas aeruginosa." J. Am. Chem. Soc. 2017, 139(4), 1448-1451.
  • Riley, T. P.; Ayres, C. M.; Hellman, L. M.; Singh, N. K.; Cosiano, M.; Cimons, J. M.; Anderson, M. J.; Piepenbrink, K. H.; Pierce, B. G.; Weng, Z.; Baker, B. M. "A Generalized Framework for Computational Design and Mutational Scanning of T Cell Binding Interfaces." Protein Eng. Des. Sel. 2016, 29(12), 595-606.
  • Spear, T. T.; Riley, T.; Lyons, G. E.; Callender, G. G.; Roszkowski, J. J.; Wang, Y.; Simms, P. E.; Scurti, G. M.; Foley, K. C.; Murray, D. C.; Hellman, L. M.; McMahan, R. H.; Rosen, H. R.; Baker, B. M.; Nishimura, M. I. "Hepatits C Virus NS3-Reactive TCRs Transfer Recognition of Multiple Naturally Occurring Mutant Epitopes to T Cells." J. Leukocyte Biol. 2016, 100(3), 545-557.
  • Hellman, L. M.; Yin, L.; Wang, Y.; Blevins, S. J.; Riley, T. P.; Belden, O. S.; Spear, T. T.; Nishimura, M. I.; Stern, L. J.; Baker, B. M. "Differential Scanning Fluorimetry Facilitates High Throughput Assessment of Class I Peptide/MHC Binding and Thermal Stability." J. Immunol. Met. 2016, 432, 95-101.

Contact Information

  • Research Assistant Professor
  • Office: A220 Harper Hall
  • Phone: 574-631-2601
  • Send an email

Primary Research Areas

Research Specialties