Lance Hellman

Lance Hellman

Biography

2017-present
Research Assistant Professor, University of Notre Dame
2012-present
Adjunct Assistant Professor, Indiana University South Bend
2013-2017
Research Scientist, University of Notre Dame
2011-2013
Postdoctoral Scholar, University of Notre Dame
2011
Ph.D. in Biochemistry, University of Kentucky
2001-2006
Cytotechnologist, Gettysburg Hospital, Gettysburg, PA
1993-2001
Cytotechnologist, Holy Spirit Hospital, Camp Hill, PA
1993
B.S. in Cytotechnology, Medical University of South Carolina
1992
B.S. in Biology, University of South Carolina

Research Interests

My research focuses on understanding the interaction between T-cell receptors and the specific antigenic peptides they recognize. My particular interest is in trying to redistribute the binding energies within the interface, between the T-cell receptor and the antigen, to reduce cross reactivity of the receptor towards other antigens.

Recent Papers

  • Riley, T.P., Hellman, L.M., Gee, M.H., Mendoza, J.L., Alonso, J.A., Foley, K.C., Nishimura, M.I., Vander Kooi, C.W., Garcia, K.C., Baker, B.M. "T cell receptor cross-reactivity expanded by dramatic peptide–MHC adaptability" 2018 Nature Chemical Biology, 14 (10), pp. 934-942. DOI: 10.1038/s41589-018-0130-4
  • Spear, T.T., Wang, Y., Smith, T.W., Jr., Simms, P.E., Garrett-Mayer, E., Hellman, L.M., Baker, B.M., Nishimura, M.I. "Altered Peptide Ligands Impact the Diversity of Polyfunctional Phenotypes in T Cell Receptor Gene-Modified T Cells" 2018 Molecular Therapy, 26 (4), pp. 996-1007. DOI: 10.1016/j.ymthe.2018.01.015
  • Moore, T., Wagner, C.R., Scurti, G.M., Hutchens, K.A., Godellas, C., Clark, A.L., Kolawole, E.M., Hellman, L.M., Singh, N.K., Huyke, F.A., Wang, S.-Y., Calabrese, K.M., Embree, H.D., Orentas, R., Shirai, K., Dellacecca, E., Garrett-Mayer, E., Li, M., Eby, J.M., Stiff, P.J., Evavold, B.D., Baker, B.M., Le Poole, I.C., Dropulic, B., Clark, J.I., Nishimura, M.I. "Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells" 2018 Cancer Immunology, Immunotherapy, 67 (2), pp. 311-325. DOI: 10.1007/s00262-017-2073-0
  • Spear, T.T., Wang, Y., Foley, K.C., Murray, D.C., Scurti, G.M., Simms, P.E., Garrett-Mayer, E., Hellman, L.M., Baker, B.M., Nishimura, M.I. "Critical biological parameters modulate affinity as a determinant of function in T-cell receptor gene-modified T-cells" 2017 Cancer Immunology, Immunotherapy, 66 (11), pp. 1411-1424. DOI: 10.1007/s00262-017-2032-9
  • Wang, Y., Singh, N.K., Spear, T.T., Hellman, L.M., Piepenbrink, K.H., McMahan, R.H., Rosen, H.R., Vander Kooi, C.W., Nishimura, M.I., Baker, B.M. "How an alloreactive T-cell receptor achieves peptide and MHC specificity" 2017 Proceedings of the National Academy of Sciences of the United States of America, 114 (24), pp. E4792-E4801. DOI: 10.1073/pnas.1700459114
  • Dik, D.A., Domínguez-Gil, T., Lee, M., Hesek, D., Byun, B., Fishovitz, J., Boggess, B., Hellman, L.M., Fisher, J.F., Hermoso, J.A., Mobashery, S.​​​​​​​ "Muropeptide binding and the X-ray structure of the effector domain of the transcriptional regulator AmpR of Pseudomonas aeruginosa" 2017 Journal of the American Chemical Society, 139 (4), pp. 1448-1451. DOI: 10.1021/jacs.6b12819

Contact Information

  • Research Assistant Professor
  • Office: A220 Harper Hall
  • Phone: 574-631-2601
  • Send an email

Primary Research Areas

Research Specialties