Lance Hellman

Lance Hellman

Research Assistant Professor

Biography

2017-present
Research Assistant Professor, University of Notre Dame
2012-present
Adjunct Assistant Professor, Indiana University South Bend
2013-2017
Research Scientist, University of Notre Dame
2011-2013
Postdoctoral Scholar, University of Notre Dame
2011
Ph.D. in Biochemistry, University of Kentucky
2001-2006
Cytotechnologist, Gettysburg Hospital, Gettysburg, PA
1993-2001
Cytotechnologist, Holy Spirit Hospital, Camp Hill, PA
1993
B.S. in Cytotechnology, Medical University of South Carolina
1992
B.S. in Biology, University of South Carolina

Research Interests

My research focuses on understanding the interaction between T-cell receptors and the specific antigenic peptides they recognize. My particular interest is in trying to redistribute the binding energies within the interface, between the T-cell receptor and the antigen, to reduce cross reactivity of the receptor towards other antigens.

Recent Papers

  • Spear, T. T.; Wang, Y.; Foley, K. C.; Murray, D. C.; Scurti, G. M.; Simms, P. E.; Garrett-Mayer, E.; Hellman, L. M.; Baker, B. M.; Nishimura, M. I. "Critical Biological Parameters Can Modulate Affinity as a Determinant of Function in T Cell Receptor Gene-Modified T Cells." Cancer Immunol. Immunother. 2017, 66(11), 1411-1424.
  • Wang, Y.; Singh, N. K.; Spear, T. T.; Hellman, L. M.; Piepenbrink, K. H.; Vander Kooi, C. W.; Rosen, H. R.; Nishimura, M. I.; Baker, B. M. "How an Alloreactive T Cell Receptor Achieves Peptide and MHC Specificity: Implications for Alloreactivity and Immunotherapy." Proc. Nat. Acad. Sci. USA 2017, 114(24), E4792-E4801.
  • Dik, D. A.; Dominguez-Gil, T.; Lee, M.; Hesek, D.; Byun, B.; Fishovitz, J.; Boggess, B.; Hellman, L. M.; Fisher, J. F.; Hermoso, J. A.; Mobashery, S. "Muropeptide Binding and the X-ray Structure of the Effector Domain of the Transcriptional Regulator AmpR of Pseudomonas aeruginosa." J. Am. Chem. Soc. 2017, 139(4), 1448-1451.
  • Riley, T. P.; Ayres, C. M.; Hellman, L. M.; Singh, N. K.; Cosiano, M.; Cimons, J. M.; Anderson, M. J.; Piepenbrink, K. H.; Pierce, B. G.; Weng, Z.; Baker, B. M. "A Generalized Framework for Computational Design and Mutational Scanning of T Cell Binding Interfaces." Protein Eng. Des. Sel. 2016, 29(12), 595-606.
  • Spear, T. T.; Riley, T.; Lyons, G. E.; Callender, G. G.; Roszkowski, J. J.; Wang, Y.; Simms, P. E.; Scurti, G. M.; Foley, K. C.; Murray, D. C.; Hellman, L. M.; McMahan, R. H.; Rosen, H. R.; Baker, B. M.; Nishimura, M. I. "Hepatits C Virus NS3-Reactive TCRs Transfer Recognition of Multiple Naturally Occurring Mutant Epitopes to T Cells." J. Leukocyte Biol. 2016, 100(3), 545-557.
  • Hellman, L. M.; Yin, L.; Wang, Y.; Blevins, S. J.; Riley, T. P.; Belden, O. S.; Spear, T. T.; Nishimura, M. I.; Stern, L. J.; Baker, B. M. "Differential Scanning Fluorimetry Facilitates High Throughput Assessment of Class I Peptide/MHC Binding and Thermal Stability." J. Immunol. Met. 2016, 432, 95-101.

Contact Information

  • Research Assistant Professor
  • Office: A220 Harper Hall
  • Phone: 574-631-2601
  • Send an email

Primary Research Areas

Research Specialties