Professor; Director, Notre Dame Radiation Laboratory
- 323 Radiation Research Building
Notre Dame, IN 46556-5674
- +1 574-631-4502
- Physical/Analytical Chemistry
Prospective Graduate Students
|2004-present||Director, Notre Dame Radiation Laboratory|
|2004-present||Professor, University of Notre Dame|
|2001-2004||Professional Specialist, Notre Dame Radiation Laboratory|
|1988-2001||Associate Professional Specialist, Notre Dame Radiation Laboratory|
|1980-1988||Assistant Professional Specialist, Notre Dame Radiation Laboratory|
|1976-1980||Research Associate, Notre Dame Radiation Laboratory|
|1974-1976||British Royal Society Research Fellow, University of Amsterdam, Netherlands|
|1974||Ph.D. in Physical and Theoretical Chemistry, University of Glasgow, Scotland|
|1971||B.Sc. in Chemistry, University of Glasgow, Scotland|
Ionizing radiation pervades our environment and affects all life on earth. The absorption of this impinging energy produces profound chemical and biochemical transformations in the materials irradiated. Professor Carmichael's research provides a fundamental molecular-level understanding of these radiation effects in matter.
The work is performed in the Notre Dame Radiation Laboratory, the premier facility for radiation chemical research in the US, supported by the Chemical Sciences Division of Basic Energy Sciences at the US Department of Energy. The NDRL provides not only access to unique experimental tools but also outstanding research opportunities for focused interdisciplinary collaborations. Knowledge gained from this research provides the scientific basis for solving problems ranging from the chemical conversion of solar energy, through nuclear energy production, environmental waste management and remediation, to biomedical radiation therapy.
Specific topics currently under active investigation include:
Radiation damage in protein crystallography
Understanding and mitigating radiation damage during macromolecular crystallography at synchrotrons
Electron-driven processes in condensed phases
Excited species in water radiolysis; radical formation in irradiated organic liquids
Radiation effects in heterogeneous systems and at interfaces
Characterizing radiation chemistry at water - ceramic oxide interfaces
Spin coupling in biomolecular NMR
Probing conformational and chemical changes in carbohydrates
- Lisouskaya, A.; Schiemann, O. and Carmichael, I. "Unveiling the Mechanism of Photodamage to Sphingolipid Molecules Via Laser Flash Photolysis and EPR" 2023 Photochemistry and Photobiology, in press. DOI: 10.1111/php.13804.
- Tetrault, T.; Meredith, R. J.; Yoon, M. K.; Canizares, C.; Oliver, A. G.; Carmichael, I. and Serianni, A. S. "One-Bond C-13-C-13 Spin-Coupling Constants in Saccharides: A Comparison of Experimental and Calculated Values by Density Functional Theory using Solid-State C-13 NMR and X-Ray Crystallography" 2023 Physical Chemistry Chemical Physics, 25 (23), pp.16048-16059. DOI: 10.1039/d2cp05363b.
- Tetrault, T.; Meredith, R. J.; Zhang, W. H.; Carmichael, I. and Serianni, A. S. "One-Bond 13C-1H and 13C-13C Spin-Coupling Constants as Constraints in MA'AT Analysis of Saccharide Conformation" 2022 Journal of Physical Chemistry B, 126 (46), pp.9506-9515. DOI: 10.1021/acs.jpcb.2c04986.
- Lisouskaya, A.; Tarabek, P.; Carmichael, I. and Bartels, D. M. "Persistent Radicals in Irradiated Imidazolium Ionic Liquids Probed by EPR Spectroscopy" 2023 Radiation Physics and Chemistry, 202, 110513. DOI: 10.1016/j.radphyschem.2022.110513.
- Lisouskaya, A.; Markad, U. S.; Carmichael, I. and Bartels, D. M. "Reactivity of Zn-Aq(+) in High-Temperature Water Radiolysis" 2022 Physical Chemistry Chemical Physics, 24 (33), pp.19882-19889. DOI: 10.1039/d2cp02434a.
- Meredith, R. J.; Carmichael, I. and Serianni, A. S. "Nonconventional NMR Spin-Coupling Constants in Oligosaccharide Conformational Modeling: Structural Dependencies Determined from Density Functional Theory Calculations" 2022 ACS Omega, 7 (27), pp.23950-23966. DOI: 10.1021/acsomega.2c02793.