Employment Opportunities

Tenured/Tenure-Track Faculty

None at this time.


Non-Tenured Faculty

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Postdoctoral

Structural and Biochemical Studies of RNA Triple Helices: The Brown Laboratory at Notre Dame is interested in understanding the biological, biochemical, and structural roles of RNA triple helices, structures that were deduced to form over 60 years ago yet only 3 examples in the human transcriptome have been validated by 3D structures. Using the MALAT1 triple helix as a model system, we are interested in several key questions. How do proteins and small molecules bind specifically to an RNA triple helix? Is there an undiscovered class of triple-stranded RNA binding proteins? What are the structural parameters of an ideal RNA triple helix? What is the folding pathway of an RNA triple helix? What other RNA triple helices exist in mammalian cells? Can we establish the “triplexome”? To investigate these questions, we are currently using a variety of approaches, including X-ray crystallography, cryo-EM, cell-based assays, molecular biology, classical biochemistry, and high-throughput methods. To apply, please submit a cover letter stating your hands-on experiences in structural and biochemical approaches (list methods used), long-term career goals, date of availability to begin postdoc research, and the name and contact information of three references. Also required is a CV including education/research experience, publications, awards and honors, and presentations. All materials should be sent to Prof. Jessica Brown at jbrown33@nd.edu

The laboratory of Prof. Juan R. Del Valle in the Department of Chemistry & Biochemistry at the University of Notre Dame is currently accepting applications for an open Postdoctoral position in Bioorganic and Medicinal Chemistry. Research projects will focus on the chemical synthesis of biologically active peptidomimetics and/or small molecules, particularly those that target protein-protein interactions and ER stress response pathways. Candidates must have a Ph.D. in chemistry and a strong background in multi-step organic synthesis. Priority will be given to highly motivated, recent Ph.D. graduates with additional experience in peptide synthesis techniques and/or structure-activity relationship studies. Excellent written and oral communication skills are required. Our group offers opportunities for additional scientific growth in the areas of biophysical chemistry, drug discovery, and chemical biology. Involvement in other ongoing interdisciplinary efforts will be an option for interested candidates. For additional information, please open the following document: Postdoc Ad Fall 2019 Bioorganic Medicinal Chemistry


Staff

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Associated and Affiliated Positions

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