Brief introduction: N-methyl-D-aspartate receptor (NMDAR) is a type of ionotropic glutamate receptor that plays an essential role in brain development and function, while dysregulation of those receptors can result in many neurological disorders as well. Unlike ifenprodil and other GluN1-GluN2B NMDAR specific inhibitors studied before, a class of allosteric inhibitors 93-series showed pH-sensitivity in their inhibition of NMDAR, leading us to think about the structural foundation of this distinguishing feature.
Reference: Regan. M. C., et al. 'Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors'. Nat. Commun. 2019. 10, 321.