More than 2000 different lipid molecules have been identified as playing major roles in human disease processes resulting in lipidomic-based therapeutics becoming novel and indispensable class of medicines. Sphingosine-1-phophate (S1P) is one of the enigmatic lipid molecules that has been established as a critical regulator in various biological processes such as vascular permeability, immune cell trafficking, angiogenesis and cell proliferation. Carrier proteins of S1P modulates the distribution and homeostasis of S1P and it is an emerging aspect which will reveal dynamic interactions between lipids and other biological molecules such as proteins. A recent study by Obinata H. et alhas identified ApoA4 as a novel S1P chaperone challenging the S1P distribution by conventional carriers ApoM and albumin.
Reference to the presenting paper-
Obinata H, Kuo A, Wada Y, et al. Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice. J Lipid Res. August 2019. doi:10.1194/jlr.RA119000277