H. Tom Soh (Stanford University)

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Location: B01 McCourtney Hall

Abstract:  A biosensor capable of continuously measuring specific molecules in the bloodstream in vivowould give clinicians a valuable window into patients’ health and their response to therapeutics. Unfortunately, continuous, real-time measurement is currently only possible for a handful of targets (i.e.glucose, and oxygen) and existing platforms for continuous measurement are not generalizable for the monitoring of other analytes.  In this talk, we will present a universal real-time biosensor technology capable of continuously tracking a wide range of circulating molecules in living animals.  Our real-time biosensor requires no exogenous reagents and can be readily reconfigured to measure different target molecules by exchanging molecular probes in a modular manner. Next, we will present the first real-time, closed loop feedback control of drug concentration in live animals using the real-time biosensor, and discuss potential applications of our technology.  Finally, we will discuss methods for generating synthetic molecular probes (aptamers) that are at the heart of these biosensor technologies

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