Tyvette Hilliard

Tyvette Hilliard

Research Assistant Professor

Biography

2018-present
Research Assistant Professor, University of Notre Dame
2015-2018
Postdoctoral Fellow, University of Notre Dame
2012-2015
Postdoctoral Fellow, University of Hawaii Cancer Center
2012
Ph.D. in Medicinal Chemistry, University of Illinois - Chicago
2007
B.S. in Chemistry and Biology, Chicago State University

Selected Awards

2017-2022
NIH-NCI Mentored Research Scientist Development Award
2016
Indiana CTSI Postdoc Challenge Award
2015-2017
University of Notre Dame Dean's Diversity Fellowship
2012
Charles Wesley Petranek Scholarship
2011-2012
University of Illinois at Chicago Abraham Lincoln Fellowship

Research Interests

The overall objective of my research is to determine the influence of host factors, including obesity, on the metastatic success of ovarian cancer (OvCa). OvCa is the deadliest gynecological cancer among U.S. women due to women presenting with advanced stage disease, with widely disseminated intraperitoneal metastasis, at diagnosis. My main project focuses on investigating the influence of maternal obesity on the metastatic success of OvCa in next generation offspring. Obesity has become a worldwide epidemic with increased prevalence in children. Maternal obesity often results in an increased risk of offspring developing obesity and obesity-linked diseases. The excessive intake of nutrients may cause epigenetic changes, consequently changing the expression of critical genes associated with physiological and pathological processes. Using established pre-clinical mouse models of diet-induced obesity and intraperitoneal metastasis, an integrated approach encompassing a variety of epigenetic, genetic, biophysical and micro-anatomical methods is used to investigate the mechanistic link between maternal obesity and OvCa metastasis in offspring.

Another project involves the histological analysis of human ovarian tumor tissues including granulosa cell tumors. The tumor tissues will be divided into cohorts according to body mass index (BMI) [low BMI (<30) and high BMI (>30)] to compare expression levels of obesity related genes and genes involved in proliferation and migration between the cohorts. The expected results will advance our understanding of the influence of host factors including obesity on ovarian cancer metastasis. An additional project uses an OvCa intraperitoneal metastasis model utilizing mesothelin wild type and knockout mice to explore the role of mesothelin expression, a glycoprotein overexpressed in OvCa, on the susceptibility of OvCa cells to adhere to the mesothelium of organs in the peritoneal cavity.

Recent Papers

  • Loughran, E. A.; Leonard, A. K.; Hilliard, T. S.; Phan, R. C.; Yemc, M. G.; Harper, E.; Sheedy, E.; Klymenko, Y.; Asem, M.; Liu, Y.; Yang, J.; Johnson, J.; Tarwater, L.; Shi, Z.; Leevy, M.; Ravosa, M. J.; Stack, M. S. "Aging Increases Susceptibility to Ovarian Cancer Metastasis in Murine Allograft Models and Alters Immune Composition of Peritoneal Adipose Tissue." Neoplasia 2018, 20(6), 621-631.
  • Loughran, E. A.; Phan, R. C.; Leonard, A. K.; Tarwater, L.; Asem, M.; Liu, Y.; Yang, J.; Klymenko, Y.; Johnson, J.; Shi, Z.; Hilliard, T. S.; Blumenthaler, M.; Leevy, M.; Ravosa, M. J.; Stack, M. S. "Multiparity activates interferon pathways in peritoneal adipose tissue and decreases susceptibility to ovarian cancer metastasis in a murine allograft model." Cancer Lett. 2017, 411, 74-81.
  • Hilliard, T. S.; Miklossy, G.; Chock, C.; Yue, P.; Williams, P.; Turkson, J. "15α-methoxypuupehenol Induces Antitumor Effects In Vitro and In Vivo against Human Glioblastoma and Breast Cancer Models." Mol. Cancer Ther. 2017, 16(4), 601-613.
  • Miklossy, G.; Youn, U. J.; Yue, P.; Zhang, M.; Chen, C. H.; Hilliard, T. S.; Paladino, D.; Li, Y.; Choi, J.; Sarkaria, J. N.; Kawakami, J. K.; Wongwiwatthananukit, S.; Chen, Y.; Sun. D.; Chang, L. C.; Turkson, J. "Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin α-2 Expression, and Induce Antitumor Effects against Human Glioma." J. Med. Chem. 2015, 58(19), 7734-7748.
  • Yue, P.; Lopez-Tapia, F.; Paladino, D.; Li, Y.; Chen, C. H.; Namanja, A. T.; Hilliard, T.; Chen, Y.; Tius, M. A.; Turkson, J. "Hydroxamic Acid and Benzoic Acid-Based STAT3 Inhibitors Suppress Human Glioma and Breast Cancer Phenotypes In Vitro and In Vivo." Cancer Res. 2015, 76(3), 652-663.
  • Miklossy, G.; Hilliard, T. S.; Turkson, J. "Therapeutic modulators of STAT signalling for human disease." Nat. Rev. Drug Discov. 2013, 12(8), 611-629.

Contact Information

  • Research Assistant Professor
  • Office: A202 Harper Hall
  • Phone: 574-631-2452
  • Send an email

Primary Research Areas

Research Specialties