Olaf Wiest

Olaf Wiest

Organic & Bioorganic reaction mechanisms


Professor, University of Notre Dame
Associate Professor, University of Notre Dame
Assistant Professor, University of Notre Dame
Postdoctoral Fellow, University of California, Los Angeles
Dr. rer. nat. University of Bonn, Germany
Diplom, University of Bonn, Germany

Selected Awards

John Kaneb Award for undergraduate teaching
Camille Dreyfus Teacher-Scholar Award
NIH First Award

Research Interests

Computational and Physical Organic Chemistry, Computational Drug Design, Biophysical Chemistry, Enzyme Mechanisms, Transition Metal Catalyzed Reactions and Design of Ligands for Enantioselective Catalysis

Recent Papers

  • Xu, W.; Arieno, M.; Löw, H.; Huang, K.; Xie, X.; Crutcher, T.; Ma, Q.; Xi, J.; Huang, B.; Wiest, O.; Hong, L.; Meggers, E. "Metal-Templated Design: Enantioselective Hydrogen-Bond-Driven Catalysis Requiring Only Parts-per-million Catalyst Loading." J. Am. Chem. Soc. 2016, 138, 8774-8780.
  • Lee, J.M.; Zhang, X.; Wu, Y.D.; Norrby, P.O.; Helquist, P.; Wiest, O. "Stereoselectivity in (Acylox)borane-Catalyzed Mukaiyama Aldol Reactions." J. Org. Chem. 2016, 81, 5314-5321.
  • Hansen, E.; Rosales, A.R.; Tutkowski, B.M.; Norrby, P.O.; Wiest, O. "Prediction of Stereochemistry using Q2MM." Acc. Chem. Res. 2016, 49, 996-1005.
  • Grigalunas, M.; Anker, T.; Norrby, P.O.; Wiest, O.; Helquist, P. "Ni-Catalyzed Alkenylation of Ketone Enolates Under Mild Conditions: Catalyst Identification and Optimization." J. Am. Chem. Soc. 2015, 137, 7019-7022.
  • Mbengue, A.; Bhattacharjee, S.; Pandharkar, T.; Liu, H.N.; Estiu, G.; Stahelin, R.V.; Rizk, S.S.; Njimoh, D.L.; Ryan, Y.; Chotivanich, K.; Nguon, C.; Ghorbal, M.; Lopez-Rubio, J.J.; Pfrender, M.; Emrich, S.; Mohandas, N.; Dondorp, A.M.; Wiest, O.; Haldar, K. "A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria." Nature 2015, 520 (7549), 683-U246.
  • Chen, K.; Zhang, X.X.; Wu, Y.D.; Wiest, O. "Inhibition and Mechanism of HDAC8 Revisited." J. Am. Chem. Soc. 2014, 136 (33), 11636-11643.

Contact Information

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