Olaf Wiest

Olaf Wiest

Organic & Bioorganic reaction mechanisms

Biography

2005-present
Professor, University of Notre Dame
2001-2005
Associate Professor, University of Notre Dame
1996-2001
Assistant Professor, University of Notre Dame
1993-1995
Postdoctoral Fellow, University of California, Los Angeles
1993
Dr. rer. nat. University of Bonn, Germany
1991
Diplom, University of Bonn, Germany

Selected Awards

2004
John Kaneb Award for undergraduate teaching
2001
Camille Dreyfus Teacher-Scholar Award
1997
NSF CAREER Award
1997
NIH First Award

Research Interests

Computational and Physical Organic Chemistry, Computational Drug Design, Biophysical Chemistry, Enzyme Mechanisms, Transition Metal Catalyzed Reactions and Design of Ligands for Enantioselective Catalysis

Recent Papers

  • B.E. Haines, O. Wiest.; "SET-induced biaryl cross-coupling: an S(RN)1 reaction" J. Org. Chem.  2014, 79, 2771-2774.
  • L. Xu, M.J. Hilton, X. Zhang, P.O. Norrby, Y.D. Wu, M.S. Sigman, O. Wiest.; "Mechanism, reactivity, and selectivity in palladium-catalyzed redox-relay Heck arylations of alkenyl alcohols" J. Am. Chem. Soc. 2014, 136, 1960-1967.
  • P. Helquist, F.R. Maxfield, N.L. Wiech, O. Wiest.; "Treatment of Niemann--pick type C disease by histone deacetylase inhibitors" Neurotherapeutics, 2013, 10, 688-697.
  • G. Estiu, N. Khatri, O. Wiest.; "Computational studies of the cholesterol transport between NPC2 and the N-terminal domain of NPC1" Biochemistry, 2013, 52, 6879-6891. 
  • K. Chen, L. Xu, O. Wiest.; "Computational exploration of zinc binding groups for HDAC inhibition", J. Org. Chem. 2013, 78, 5051-5055.

Contact Information

Primary Research Areas

Research Specialties