- Adjunct Professor, Department of Chemistry and Biochemistry, University of Notre Dame
- Professor, Department of Pediatrics and Integrative Biology Graduate Program, Indiana University School of Medicine, South Bend, IN
- Associate Professor, Department of Pediatrics, Division of Critical Care, Division of Pulmonary and Vascular Biology, Integrative Biology Graduate Program, UT Southwest Medical Center, Dallas, TX
- Associate Professor, Department of Surgery, Division of Surgical Sciences; Department of Pediatrics, UMDNJ Robert Wood Johnson Medical School
- Assistant Professor, Department of Surgery, Division of Surgical Sciences; Department of Pediatrics, UMDNJ Robert Wood Johnson Medical School
- Director, Pediatric Critical Care Fellowship, Children's Hospital of Los Angeles
- Assistant Professor, Department of Pediatrics, Critical Care Medicine, Division of Cardiothoracic Critical Care, University of Southern California
- Assistant Professor, Department of Pediatrics, Division of Critical Care Medicine, Columbia University, New York
- Instructor, Department of Anesthesia, Division of Pediatrics Critical Care Medicine, University of Pittsburgh
- Fellowship, Pediatric Critical Care, Children's Hospital of Pittsburgh, Pittsburgh, PA
- Pediatric Residency, Children's Hospital, Columbus, OH
- Pediatric Internship, Children's Hospital, Columbus, OH
- M.D., University of Missouri Six-Year Medical School
- B.A.in Biology, University of Missouri
- Member, Society of Pediatric Research
- Dr. Edward Livingston Trudeau Scholar, American Lung Association
- Finalist for the Louis N. Katz Basic Science Research Prize, American Heart Association
- Pediatric Research Award, Society of Critical Care Medicine
- Clinician Scientist Award, American Heart Association
The Schwarz lab uses transgenic mice, three dimensional cell culture, in vivo tumor, and lung developmental models to determine mechanisms by which the vasculature regulates cancer progression and alveolar formation.
Our main interests are the role that the anti-angiogenic mediator Endothelial Monocyte Activating Polypeptide II (EMAP II, also known as AIMP-1, Scye-1, and p43) has in lung and tumor development. On the cell surface, EMAP II undergoes proteolytic cleavage to generate an extracellular »22-kDa C-terminal peptide that functions as an anti-angiogenic protein through inhibition of endothelial cell adhesion to fibronectin, blockade of fibronectin matrix assembly via a5b1 integrin, and interference with vascular endothelial growth factor (VEGF) induced pro-angiogenic signaling.
Earlier studies identified a direct interaction between vascular growth factors and the regulation of tissue formation. Using pulmonary developmental models, we have shown that vascular growth factors can also impact epithelial –mesenchymal transdifferentiation, extracellular matrix deposition, and airway simplification resulting in physiologic changes in pulmonary function. Currently, our studies focus on the mechanisms that modulate pulmonary vascular growth and the subsequent impact that the vasculature has on alveolar growth by examining vessel mediation of interstitial lung disease, deposition of the extracellular matrix protein, and epithelial cell proliferation.
By using a pancreatic cancer models (intraperitoneal and subQ), targeted multi-drug therapy strategies are utilized to determine the role that anti-angiogenic factors alone and in combination with chemotherpeutic agents have in regulating tumor cell proliferation and microenvironment including the dense tumor stromal layer, extracellular matrix deposition and vessel formation. Recent studies utilizing this strategy demonstrated that this multi-target approach is effective and superior to current conventional chemotherapeutic strategies.
- Lee, D.D.; Lal, C.V.; Persad, E.A.; Lowe, W.; Schwarz, A.M.; Awasthi, N.; Schwarz, R.E.; Schwarz, M.A. "EMAP II Mediates Macrophage Migration in Development of Hyperoxia-Induced Lung Disease of Prematurity." Am. J. Respir. Cell Mol. Biol. 2016, PMID:27254784.
- Lee, D.D.; Schwarz, M.A. "Adapted approach to profile genes while reconciling Vegf-a mRNA expression in the developing and injured lung." Am. J. Physiol. - Lung C. 2015, 308 (12), L1202-1211.
- Xu, H.M.; Malinin, N.L.; Awasthi, N.; Schwarz, R.E.; Schwarz, M.A. "The N Terminus of Pro-endothelial Monocyte-activating Polypeptide II (EMAP II) Regulates Its Binding with the C Terminus, Arginyl-tRNA Synthetase, and Neurofilament Light Protein." J. Biol. Chem. 2015, 290 (15), 9753-9766.
- Awasthi, N.; Hinz, S.; Brekken, R.A.; Schwarz, M.A.; Schwarz, R.E. "Nintedanib, a triple angiokinase inhibitor, enhances cytotoxic therapy response in pancreatic cancer." Cancer Lett. 2015, 358 (1), 59-66.
- Yuan, C.; Yan, L.; Solanki, P.; Vatner, S.F.; Vatner, D.E.; Schwarz, M.A. "Blockade of EMAP II protects cardiac function after chronic myocardial infarction by inducing angiogenesis." J. Mol. Cell. Cardiol. 2015, 79, 224-231.
- Awasthi, N.; Zhang, C.H.; Schwarz, A.M.; Hinz, S.; Schwarz, M.A.; Schwarz, R.E. "Enhancement of Nab-Paclitaxel Antitumor Activity through Addition of Multitargeting Antiangiogenic Agents in Experimental Pancreatic Cancer." Mol. Cancer Ther. 2014, 13(5), 1032-1043.