Jaroslav Zajicek

Jaroslav Zajicek

Professional Specialist

Biography

1995-present
Director of the Magnetic Resonance Research Center, University of Notre Dame
1991-1995
Manager, NMR Spectroscopy Center, Washington State University
1980-1991
Senior NMR Spectroscopist, Institute of Organic Chemistry & Biochemistry, Czechoslovak Academy of Sciences
1980
C.Sc. (Ph.D.) in Experimental Physics, Charles University, Prague, Czech Republic
1970
M.S., Czech Technical University, Prague, Czech Republic

Research Interests

His current interests are applications of NMR spectroscopy techniques to study structures and dynamics of proteins, natural products and carbohydrates.

Research Support Services

Dr. Zajicek maintains the NMR facility of the University. The Core is equipped with seven NMR spectrometers for liquid analysis ranging in magnetic field strength from 7.05-18.79 T which corresponds to proton resonance frequencies of 300-800 MHz. Triple resonance cryoprobes of the 700 and 800 MHz spectrometers allow for the measurement of extremely dilute sample solutions.

Recent Papers

  • Yuan, Y.; Zajicek, J.; Qiu, C.; Chandrahas, V.; Lee, S. W.; Ploplis, V. A.; Castellino, F. J. "Conformationally organized lysine isosteres in Streptococcus pyogenes M protein mediate direct high-affinity binding to human plasminogen." J. Biol. Chem. 2017, 292, 15016-15027.
  • Ghosh, M.; Miller, P. A.; Mollmann, U.; Claypoo, W. D.; Schroeder, V. A.; Wolter, W. R.; Suckow, M.; Yu, H.; Li, S.; Huang, W.; Zajicek, J.; Miller, M. J. "Targeted Antibiotic Delivery: Selective Siderophore Conjugation with Daptomycin Confers Potent Activity against Multidrug Resistant Acinetobacter baumannii Both in Vitro and in Vivo." J. Med. Chem. 2017, 60, 4577-4583.
  • Yuan, Y.; Balsara, R. D.; Zajicek, J.; Kunda, S.; Castellino, F. J. "Discerning the Role of the Hydroxyproline Residue in the Structure of Conantokin RI-B and Its Role in GluN2B Subunit-Selective Antagonistic Activity toward N-Methyl-D-Aspartate Receptors." Biochemistry 2016, 55, 7112-7122.
  • Stephenson, C. A.; O'Brien, W. A.; Penninger, M. W.; Schneider, W. F.; Gillett-Kunnath, M.; Zajicek, J.; Yu, K. M.; Kudrawiec, R.; Stillwell, R. A.; Wistey, M. A. "Band structure of germanium carbides for direct bandgap silicon photonics." J. Appl. Phys. 2016, 120, 053102.
  • Kostochka, M. L.; Zajicek, J.; Fuselier, J. A.; Etienne, M. A.; Sun, L.; Coy, D. H. "Novel Tandem Aldol Intramolecular Cyclization of Substituted N-Benzylpiperidine-4-one: Synthesis of Novel-Type Nitrogen 2,8-Phenanthroline Heterocycles." J. Heterocycl. Chem. 2015, 52, 1723-1730.
  • Galimand, M.; Fishovitz, J.; Lambert, T.; Barbe, V.; Zajicek, J.; Mobashery, S.; Courvalin, P. "AAC(3)-XI, a New Aminoglycoside 3-N-Acetyltransferase from Corynebacterium striatum." Antimicrob. Agents Chemother. 2015, 59, 5647-5653.

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