Başar Bilgiçer

Başar Bilgiçer

Biophysical Chemistry and Biomolecular Drug Design

Biography

2015-present
Associate Professor, Department of Chemical and Biomolecular Engineering, University of Notre Dame
2015-present
Concurrent Associate Professor, Department of Chemistry and Biochemistry, University of Notre Dame
2008-2015
Assistant Professor, Department of Chemical and Biomolecular Engineering, University of Notre Dame
2008-2015
Concurrent Assistant Professor, Department of Chemistry and Biochemistry, University of Notre Dame
2005-2008
Postdoctoral Fellow, Harvard University
2005
Ph.D. in Chemistry, Tufts University
1998
B.S. in Chemistry, Bogazici University, Turkey

Research Interests

Multivalent biomolecular interactions are very important in biological systems. A deeper understanding of the thermodynamics and kinetics of multivalent interactions in biological systems is imperative in the development of new diagnostic and therapeutic agents. My lab focuses on both understanding the basic dynamic principles of multivalent biomolecular interactions, as well as design of multivalent therapeutic and diagnostic molecules which will deliver novel solutions to complex diseases (e.g. cancer, autoimmune diseases, and allergies).

Recent Papers

  • Deak, P.E.; Vrabel, M.R.; Pizzuti, V.J.; Kiziltepe, T.; Bilgicer, B. "Nanoallergens: A multivalent platform for studying and evaluating potency of allergen epitopes in cellular degranulation." Exp. Biol. Med. 2016, 241(9), 996-1006.
  • Mustafaoglu, N.; Alves, N.J.; Bilgicer, B. "Oriented Immobilization of Fab Fragments by Site-Specific Biotinylation at the Conserved Nucleotide Binding Site for Enhanced Antigen Detection." Langmuir 2015, 31(35), 9728-9736.
  • Stefanick, J.F.; Kiziltepe, T.; Bilgicer, B. "Improved Peptide-Targeted Liposome Design Through Optimized Peptide Hydrophilicity, Ethylene Glycol Linker Length, and Peptide Density." J. Biomed. Nanotechnol. 2015, 11(8), 1418-1430.
  • Mustafaoglu, N.; Alves, N.J.; Bilgicer, B. "Site-specific fab fragment biotinylation at the conserved nucleotide binding site for enhanced ebola detection." Biotechnol. Bioeng. 2015, 112(7), 1327-1334.
  • Ashley, J.D.; Stefanick, J.F.; Schroeder, V.A.; Suckow, M.A.; Alves, N.J.; Suzuki, R.; Kikuchi, S.; Hideshima, T.; Anderson, K.C.; Kiziltepe, T.; Bilgicer, B. "Liposomal carfilzomib nanoparticles effectively target multiple myeloma cells and demonstrate enhanced efficacy in vivo." J. Control. Release 2014, 196, 113-121.
  • Handlogten, M.W.; Deak, P.E.; Bilgicer, B. "Two-Allergen Model Reveals Complex Relationship between IgE Crosslinking and Degranulation." Chem. Biol. 2014, 21(11), 1445-1451.

Contact Information

Primary Research Areas

Research Specialties