- Assistant Professor – University of Notre Dame, current
- Research Fellow - National Institute of Diabetes and Digestive and Kidney Diseases, NIH, 2007-2009
- NRC Postdoctoral Fellow - National Institute of Standards and Technology, 2005-2007
- Ph. D. -University of Illinois at Urbana-Champaign, 2005
- B.S. - The Ohio State University, 2000
Research in the Schultz lab focuses on understanding how the spatial organization of molecules affects their behavior. We utilize laser spectroscopy, including nonlinear spectroscopic methods, and also spectroscopic imaging modalities such as Raman near-field scanning optical microscopy, which is capable of vibrational spectroscopic imaging with a spatial resolution of tens of nanometers.
One area where molecular organization plays an important role is the behavior observed in cellular membranes. We are interested in understanding how the organization of molecules in biomembranes impact biomedical issues such as dysfunctional cellular pathways that cause disease, viral and bacterial infection, and drug delivery. These interactions occur at the nanometer length scale, necessitating the development of new methods.
A second area involves understanding how chemical heterogeneity affects reactivity. Bi-metallic nanoparticles, used as catalysts in fuel cells, often show chemical activity that the individual components do not. Understanding the molecular interactions associated with these composite materials is important for developing new sources of energy. Methods being developed in our lab have the potential to offer new insights into these processes.
Asiala, S.M., Schultz, Z.D. “Label-Free In Situ Detection of Individual Macromolecular Assemblies by Surface Enhanced Raman Scattering” Chemical Communications, 2013, 49(39), 4340-4342
Alexander, K.D., Schultz, Z.D. “Tip-Enhanced Raman Detection of Antibody Conjugated Nanoparticles on Cellular Membranes”, Analytical Chemistry, 2012, 84(17), 7408-7414
Carrier, S.L., Kownacki, C.M., Schultz, Z.D. “Protein-Ligand Binding Investigated by a Single Nanoparticle-TERS Approach.” Chemical Communications, 2011, 47(7), 2065-2067
Schultz, Z.D., Levin I.W., “Vibrational Spectroscopy of Biomembranes” Annual Reviews of Analytical Chemistry, 4, 2011, 343-366
Asiala, S.M., Schultz, Z.D. “Characterization of Hotspots in a Highly Enhancing SERS Substrate”, Analyst, 2011, 136(21), 4472-4479
Marr, J.M., Li, F., Petlick, A.R., Schafer, R., Hwang,C-T, Chabot, A., Ruggiero,S.T., Tanner, C.E., Schultz, Z.D. “The Role of Lateral Tension in Calcium induced DPPS Vesicle Rupture”, Langmuir, 2012, 28(32), 11874-11880
Primary Research Areas
- Karen A. Antonio
- Steven Asiala
- Matthew R. Bailey
- Lawrence Itela
- Kevin Jacobs
- James Marr
- Hao Wang
- Adelia Tuse
- Rachael Bridgman