Viktor Krchnak, Research Professor

Biography

Viktor Krchňák studied chemistry at the Faculty of Natural Sciences of the Masaryk University in Brno, Czechoslovakia. He earned his PhD in organic chemistry from the Institute of Organic Chemistry and Biochemistry of the Czechoslovak Academy of Sciences in Prague, under the supervision of Prof. Zdenek Arnold. After holding several industrial positions with small biotech companies in the US, he joined the faculty of the University of Notre Dame as a research professor in May 2003.

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Research Interests

Research interest covers combinatorial chemistry in general and solid phase chemistry in particular. His group introduced novel coding technique for the synthesis on modular solid support (lantern necklace coding), new concept for the solid phase synthesis of traceless heterocyclic libraries, cleavage of resin-bound compounds by gaseous reagents, the “split-split” method for the synthesis of sizable combinatorial libraries (up to 60,000 compounds), instrumentation and logistics for high throughput organic synthesis. Numerous his inventions resulted in commercially available personal chemistry tools (www.torviq.com).

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Recent Papers

Stanger,K.J. and Krchnak,V. J.Comb.Chem. 2006, 8, 435-439. Polymer-Supported N-Derivatized-O-Linked Hydroxylamine for Concurrent Solid-Phase Synthesis of Diverse N-Alkyl and N-H Hydroxamates.
Krchnak,V. Mini Reviews in Medicinal Chemistry 2006, 6, 27-36. Solid-phase synthesis of biologically interesting compounds containing hydroxamic acid moiety.
K. J. Stanger and V. Krchnak. Incorporation of the Wang Linker Upon Cleavage from Polystyrene-based Resin to Form O-(4-Hydroxy)benzyl Derivatives. J.Comb.Chem. 8:652-654, 2006.
K. J. Stanger, D. Sliva, J. Jiang, and V. Krchnak. Synthesis and screening of N-alkyl hydroxamates for inhibition of cancer cell proliferation. Comb.Chem High Throughput Screen. 9:651-661, 2006

0. D. Hesek, M. Toth, V. Krchnak, R. Fridman, and S. Mobashery. Synthesis of an Inhibitor-Tethered Resin for Detection of Active Matrix Metalloproteinases Involved in Disease. J.Org.Chem. 71:5848-5854, 2006.

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Contact Information

  • Research Professor
  • Office: 360/366 Stepan
  • Phone: 574.631.5113
  • Contact by Email

Primary Research Areas

Research Specialties