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Structure of Helix III in 5S rRNA
The solution structure of an RNA fragment representing helix III in Xenopus oocyte 5S rRNA was determined using NMR spectroscopy. The two unpaired adenosines (red) are stacked on each other in the minor groove and on the 3'-flanking guanosine (green). This appears to be the site of a conformational switch. Nucleotide analog interference mapping (NAIM) indicates that the adenosines remain stacked when TFIIIA is bound, but that they form an A-platform when ribosomal protein L5 is bound.
From Huber et al. J. Mol. Biol. 312: 823 (2001)
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