Faculty & Research // Department of Chemistry and Biochemistry // University of Notre Dame

Biography

1993 Dr. rer. nat. University of Bonn, Germany (Prof. E. Steckhan)
1993-1995 Postdoctoral Fellow, Dept. of Chemistry, UCLA (Prof. K. N. Houk)
1995 Visiting Assistant Professor, University of Notre Dame
1996-2001 Assistant Professor, University of Notre Dame
1999–present PI, Walther Cancer Research Center
2001–2005 Associate Professor, University of Notre Dame
2005- present Professor, University of Notre Dame

Awards
1997 NIH FIRST Award
1997 NSF Carreer Award
2001 Camille Dreyfus Teacher-Scholar Award
2004 Kaneb Teaching Award

Research Interests

Computational and Physical Organic Chemistry, Computational Drug Design, Biophysical Chemistry, Enzyme Mechanisms, Transition Metal Catalyzed Reactions and Design of Ligands for Enantioselective Catalysis

Recent Papers

P. J. Donoghue, P. Helquist, P. O. Norrby, O. Wiest "Fast and Accurate Prediction of Enantioselectivity in Rhodium Catalyzed Hydrogenations" J. Am. Chem. Soc. 2009, 131, 410-411.

J.C. Adams, M.J. Keiser, L. Basuino, H.F. Chambers, D.-S. Lee, O. Wiest, P.C. Babbitt "The Chemical Diversity of Drugs from the Viewpoint of Small Molecule Metabolism" PLoS Comp. Biol. 2009, 5, e1000474

Bowers, A. L.; Greshok, T. J.; West, N.; Estiu, G., Schreiber, S. L.; Wiest, O.; Williams, R. M.; Bradner, J. E. "Synthesis and Conformation-Activity Relationships of the Peptide Isosteres of FK228 and Largazole" J. Am. Chem. Soc. 2009, 131, 2900-2905

P. J. Donoghue, P. Helquist, P. O. Norrby, O. Wiest "Development of a Q2MM Force Field for the Asymmetric Rhodium Catalyzed Hydrogenation of Enamides" J. Chem. Theor. Comp. 2008, 4 1313-1323

G. Estiu, E. Greenberg, C. B. Harrison, R. Mazitschek, J. E. Bradner, O. Wiest "On the structural origin of selectivity in Class II selective Histone Deacetylase Inhibitors" J. Med. Chem. 2008, 51, 2898-2906

L. L. O’Neil, O. Wiest "Sequence dependence in base flipping: experimental and computational studies" Org. Biomol. Chem 2008, 6, 485-492